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CP-94,253 Reference Spoljašnje veze Мени за навигацију131084-35-0402967710.1002/ddr.4302603051729149010.1016/j.ejphar.2006.12.01219211971у

Агонисти серотонинског рецептораФенолни етриПиридини


agonistserotoninskog5-HT1Breceptorakokaina










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CP-94,253




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CP-94,253
CP-94253 structure.png

IUPAC ime
3-(1,2,5,6-tetrahidro-4-piridil)-5-propoksipirolo[3,2-b]piridin
Identifikatori
CAS broj
131084-35-0 ДаY
ATC kodnone
PubChemCID 4029677
Hemijski podaci
Formula
C15H19N3O
Molarna masa257,330 g/mol



CP-94,253 je lek koji deluje kao potentan i selektivan agonist serotoninskog 5-HT1B receptora, sa aproksimativno 25x i 40x selektivnošću u odnosu na blisko srodne 5-HT1D i 5-HT1A receptore.[1] On pokazuje opseg biheviouralnih efekata u životinjskim studijama, uključujući promovisanje budnosti putem povećanja dopaminskog otpuštanja u mozgu,[2][3] redukovanje unosa hrane i povećanja sitosti,[4][5][6] pojačanja dejstva kokaina,[7][8][9][10] kao i moguće antidepresivno dejstvo.[11]



Reference




  1. ^ Koe KB, Nielsen JA, Macor JE, Heym J. Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253. Drug Development Research. 1992;26(3):241-250. doi:10.1002/ddr.430260305


  2. ^ Monti JM, Monti D, Jantos H, Ponzoni A. Effects of selective activation of the 5-HT1B receptor with CP-94,253 on sleep and wakefulness in the rat. Neuropharmacology. 1995 Dec;34(12):1647-51. PMID 8788962


  3. ^ Iyer RN, Bradberry CW. Serotonin-mediated increase in prefrontal cortex dopamine release: pharmacological characterization. Journal of Pharmacology and Experimental Therapeutics. 1996 Apr;277(1):40-7. PMID 8613947


  4. ^ Halford JC, Blundell JE. The 5-HT1B receptor agonist CP-94,253 reduces food intake and preserves the behavioural satiety sequence. Physiology and Behaviour. 1996 Sep;60(3):933-9. PMID 8873272


  5. ^ Lee MD, Simansky KJ. CP-94,253: a selective serotonin1B (5-HT1B) agonist that promotes satiety. Psychopharmacology (Berlin). 1997 Jun;131(3):264-70. PMID 9203237


  6. ^ Lee MD, Kennett GA, Dourish CT, Clifton PG. 5-HT1B receptors modulate components of satiety in the rat: behavioural and pharmacological analyses of the selective serotonin1B agonist CP-94,253. Psychopharmacology (Berlin). 2002 Oct;164(1):49-60. PMID 12373419


  7. ^ Parsons LH, Weiss F, Koob GF. Serotonin1B receptor stimulation enhances cocaine reinforcement. Journal of Neuroscience. 1998 Dec 1;18(23):10078-89. PMID 9822762


  8. ^ Przegalinski E, Filip M, Papla I, Siwanowicz J. Effect of serotonin (5-HT)1B receptor ligands on cocaine sensitization in rats. Behavioural Pharmacology. 2001 Apr;12(2):109-16. PMID 11396515


  9. ^ Przegaliński E, Gołda A, Frankowska M, Zaniewska M, Filip M (2007). „Effects of serotonin 5-HT1B receptor ligands on the cocaine- and food-maintained self-administration in rats”. European Journal of Pharmacology. 559 (2-3): 165—72. PMID 17291490. doi:10.1016/j.ejphar.2006.12.012. 


  10. ^ Przegaliński E, Gołda A, Filip M (2008). „Effects of serotonin (5-HT)(1B) receptor ligands on cocaine-seeking behavior in rats”. Pharmacological Reports : PR. 60 (6): 798—810. PMID 19211971. 


  11. ^ Tatarczyńska E, Antkiewicz-Michaluk L, Kłodzińska A, Stachowicz K, Chojnacka-Wójcik E. Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: a possible mechanism of action. European Journal of Pharmacology. 2005 May 23;516(1):46-50. PMID 15913599



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