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Oksaflozan Reference Literatura Spoljašnje veze Мени за навигацију26629-86-7WHO432824382782V4WLW77V5QD07340Index Nominum 2000: International Drug Directory (Book with CD-ROM)161609461542141Pharmaceutical manufacturing encyclopediaIndex Nominum 2000: International Drug Directory (Book with CD-ROM)46037574849381582104Oxaflozane: The Merck IndexOxaflozane: Martindale: The Complete Drug Referenceуу

МорфолиниОрганофлуориди


antidepresivanksiolitik1982depresijeprolekN-dealkiloksaflozanneselektivniagonistserotoninskih receptora5-HT1A5-HT2A5-HT2CMPSOPSImeprdsrdodbpasspecspvoprocN5A5B5C6A6B6D










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Oksaflozan




Из Википедије, слободне енциклопедије






Иди на навигацију
Иди на претрагу























Oksaflozan
Oxaflozane.svg

IUPAC ime
4-propan-2-il-2-[3-(trifluorometil)fenil]morfolin
Klinički podaci
Način primeneOralno
Pravni status
Pravni status

  • ℞ (Prescription only)

Identifikatori
CAS broj
26629-86-7 ДаY
ATC kod
N06AX10 (WHO)
PubChemCID 432824
ChemSpider382782
UNII
V4WLW77V5Q ДаY
KEGGD07340
Hemijski podaci
Formula
C14H18F3NO
Molarna masa273,29 g/mol



Oksaflozan (Confliktan) je antidepresiv i anksiolitik koji je uveden u prodaju 1982. za tretmant depresije, ali je u međuvremenu izašao iz upotrebe.[1][2] On je prolek za N-dealkiloksaflozan, koji deluje kao neselektivni agonist serotoninskih receptora: 5-HT1A (pKi = 7,1), 5-HT2A (pKi = 6,0), i 5-HT2C (pKi = 7,5).[3] Oksaflozan potencijalno ima i antiholinergičko dejstvo pri visokim dozama.[4]



Reference




  1. ^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. стр. 766. ISBN 978-3-88763-075-1. 


  2. ^ Sittig 1988, стр. 1122.


  3. ^ Leysen DC (1999). „Selective 5-HT2C agonists as potential antidepressants”. IDrugs : the Investigational Drugs Journal. 2 (2): 109—20. PMID 16160946. 


  4. ^ Dutertre JP, Barbier P, Suc AL, Jonville AP, Autret E (1992). „Oxaflozane overdose in a child”. Journal of Toxicology. Clinical Toxicology. 30 (1): 123—6. PMID 1542141. 



Literatura



  • Sittig, Marshall (1988). Pharmaceutical manufacturing encyclopedia. Park Ridge, N.J., U.S.A: Noyes Publications. стр. 1756. ISBN 978-0-8155-1144-1. 


  • Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. стр. 1932. ISBN 978-3-88763-075-1. 


  • Rascol A, Maurel H, David J, Layani M (1974). „[Preliminary clinical results of a new non tricyclic antidepressive drug: oxaflozane]”. Thérapie (на језику: French). 29 (1): 95—9. PMID 4603757. CS1 одржавање: Непрепознат језик (веза)


  • Hache J, Duchene-Marullaz P, Streichenberger G (1974). „[Pharmacological profile of a new non tricyclic antidepressant: oxaflozane (1,766 Cerm)]”. Thérapie (на језику: French). 29 (1): 81—93. PMID 4849381. CS1 одржавање: Непрепознат језик (веза)


  • Constantin M, Pognat JF (1979). „Comparative study of oxaflozane urinary metabolism in man, the dog and the rat. Identification of the principal metabolites”. Arzneimittel-Forschung. 29 (1): 109—14. PMID 582104. 


  • Bertolino A, palermo M, Porro V (1985). „Oxaflozane, a new nontricyclic antidepressant in the treatment of anxiety-depressions syndromes.”. Acta Ther (11): 209—218. 


  • Aguglia E (1986). „On the therapetic value of axaflozane: Its application in the treatment of emotional disturbances of the anxious-depressive type accompanied by somatic manifestations.”. Acta Ther (12): 259—267. 


Spoljašnje veze




  • Oxaflozane: The Merck Index[мртва веза]

  • Oxaflozane: Martindale: The Complete Drug Reference











Преузето из „https://sr.wikipedia.org/w/index.php?title=Oksaflozan&oldid=20886561”










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