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Vilazodon Садржај Farmakologija References Vidi još Spoljašnje veze Мени за навигацијуPotrošačka informacije o lekua611020Vilazodon163521-12-8WHO69183135293518S239O2OOV3D09698CHEMBL43984917351874„FDA approves Clinical Data Inc's antidepressant”„FDA approves Clinical Data Inc's antidepressant”„Clinical Data, Inc. - Clinical Data, Inc. Submits New Drug Application for Vilazodone for the Treatment of Major Depressive Disorder”оригинала„Behavioral and neurochemical effects of 5-(4-[4-(5-Cyano-3-indolyl)-butyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide (EMD 68843): a combined selective inhibitor of serotonin reuptake and 5-hydroxytryptamine(1A) receptor partial agonist”1218368310.1124/jpet.102.034280„Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone”1574072410.1016/j.ejphar.2005.01.018уу

АмидиБензофураниИндолиНитрилиПиперазиниИнхибитори преузимања серотонинаАгонисти серотонинског рецептора


serotinergičkiantidepresivkliničke depresije2011inhibitor preuzimanja serotoninaparcijalni agonist5-HT1A receptoraafinitetserotoninske receptore5-HT1D5-HT2A5-HT2CMPSOPSImeprdsrdodbpasspecspvoprocN5A5B5C6A6B6D










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Vilazodon




Из Википедије, слободне енциклопедије






Иди на навигацију
Иди на претрагу




































Vilazodon (Viibryd) je serotinergički antidepresiv koji je razvijen za tretman kliničke depresije.[1] FDA je odobrila upotrebu vilazodona 2011.[2][3][4]




Садржај





  • 1 Farmakologija


  • 2 References


  • 3 Vidi još


  • 4 Spoljašnje veze




Farmakologija


Vilazodon deluje kao inhibitor preuzimanja serotonina (IC50 = 0.5 nM) i parcijalni agonist 5-HT1A receptora (IC50 = 0.2 nM; IA = ~60-70%).[5][6] On ima neznatan afinitet za druge serotoninske receptore kao što je 5-HT1D, 5-HT2A, i 5-HT2C.[5][6]



References




  1. ^ de Paulis T (2007). „Drug evaluation: Vilazodone--a combined SSRI and 5-HT1A partial agonist for the treatment of depression”. IDrugs : the Investigational Drugs Journal. 10 (3): 193—201. PMID 17351874. 


  2. ^ „FDA approves Clinical Data Inc's antidepressant”. Reuters. 22. 1. 2011. 


  3. ^ „FDA approves Clinical Data Inc's antidepressant”. Reuters. 22. 1. 2011. 


  4. ^ „Clinical Data, Inc. - Clinical Data, Inc. Submits New Drug Application for Vilazodone for the Treatment of Major Depressive Disorder”. Архивирано из оригинала на датум 18. 08. 2011. 


  5. ↑ 5,05,1 Page ME; Cryan JF; Sullivan A; et al. (2002). „Behavioral and neurochemical effects of 5-(4-[4-(5-Cyano-3-indolyl)-butyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide (EMD 68843): a combined selective inhibitor of serotonin reuptake and 5-hydroxytryptamine(1A) receptor partial agonist”. The Journal of Pharmacology and Experimental Therapeutics. 302 (3): 1220—7. PMID 12183683. doi:10.1124/jpet.102.034280. CS1 одржавање: Експлицитна употреба et al. (веза)


  6. ↑ 6,06,1 Hughes ZA; Starr KR; Langmead CJ; et al. (2005). „Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone”. European Journal of Pharmacology. 510 (1–2): 49—57. PMID 15740724. doi:10.1016/j.ejphar.2005.01.018. CS1 одржавање: Експлицитна употреба et al. (веза)




Vidi još


  • Etoperidon

  • Nefazodon

  • Trazodon

  • Vortioksetin


Spoljašnje veze




Vilazodon
Vilazodone.svg

IUPAC ime
5-(4-[4-(5-cijano-1H-indol-3-il)butil]piperazin-1-il)benzofuran-2-karboksamid
Klinički podaci
Prodajno imeViibryd
Drugs.comPotrošačka informacije o leku
MedlinePlusa611020
Podaci o licenci


  • US FDA: Vilazodon

Kategorija trudnoće


  • US: C (Mogući rizik)

Način primeneOralno
Pravni status
Pravni status


  • US: ℞-only


Farmakokinetički podaci
Poluvreme eliminacije20-24 sata

Identifikatori
CAS broj
163521-12-8 ДаY
ATC kod
N06AX24 (WHO)
PubChemCID 6918313
ChemSpider
5293518 ДаY
UNII
S239O2OOV3 ДаY
KEGG
D09698 ДаY
ChEMBL
CHEMBL439849 ДаY
Hemijski podaci
Formula
C26H27N5O2
Molarna masa441,524 g/mol












Преузето из „https://sr.wikipedia.org/w/index.php?title=Vilazodon&oldid=21847563”










Мени за навигацију



























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