Feniramin Садржај Osobine Stereoizomerizam Reference Literatura Spoljašnje veze Мени за навигацијуMonografija86-21-5WHO4761DB016204597CHEMBL1193„DrugBank 3.0: a comprehensive resource for omics research on drugs”30137092105968210.1093/nar/gkq1126уреди„DrugBank: a knowledgebase for drugs, drug actions and drug targets”22388891804841210.1093/nar/gkm958уреди„Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”10.1021/jp980230o„Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”1174957310.1021/ci000392tуреди„Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”1102028610.1021/jm000942eуредиGoodman & Gilman's The Pharmacological Basis of Therapeutics10.1036/0071422803Foye's Principles of Medicinal ChemistryFeniraminVikimedijinoj ostaviPheniramine
АнтипруритициАминиПиридини
organsko jedinjenjeatomaugljenikamolekulsku masuDaracemat
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Feniramin
Иди на навигацију
Иди на претрагу
 | |
| Klinički podaci | |
|---|---|
| Prodajno ime | AVIL, Metron, Pyriton, Trimeton |
| Drugs.com | Monografija |
| Način primene | Oralno |
| Identifikatori | |
| CAS broj | 86-21-5  Y |
| ATC kod | R06AB05 (WHO) |
| PubChem | CID 4761 |
| DrugBank | DB01620 Y |
| ChemSpider | 4597 Y |
| ChEMBL | CHEMBL1193 Y |
| Hemijski podaci | |
| Formula | C16H20N2 |
| Molarna masa | 240,343 |
SMILES
| |
InChI
| |
| Fizički podaci | |
| Tačka ključanja | 181 °C (358 °F) |
Feniramin je organsko jedinjenje, koje sadrži 16 atoma ugljenika i ima molekulsku masu od 240,343 Da.[1][2]
Садржај
1 Osobine
2 Stereoizomerizam
3 Reference
4 Literatura
5 Spoljašnje veze
Osobine
| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 2 |
| Broj donora vodonika | 0 |
| Broj rotacionih veza | 5 |
Particioni koeficijent[3] (ALogP) | 3,0 |
Rastvorljivost[4] (logS, log(mol/L)) | -4,2 |
Polarna površina[5] (PSA, Å2) | 16,1 |
Stereoizomerizam
Feniramin sadrži stereocentar i sastoji se od dva enantiomera. Ovo je racemat, tj. Smjesa od 1: 1 ( R ) i ( S ) - oblik:[6]
| Enantiomeri feniramina | |
|---|---|
 CAS-Nummer: 56141-72-1 |  CAS-Nummer: 23201-92-5 |
Reference
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126.
^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889. PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
^ F. v. Bruchhausen, G. Dannhardt, S. Ebel, A. W. Frahm, E. Hackenthal, U. Holzgrabe (Hrsg.): Hagers Handbuch der Pharmazeutischen Praxis: Band 9: Stoffe P-Z, Springer Verlag, Berlin, Aufl. 5, 2014, S. 121, ISBN 978-3-642-63389-8.
Literatura
.mw-parser-output .refbeginfont-size:90%;margin-bottom:0.5em.mw-parser-output .refbegin-hanging-indents>ullist-style-type:none;margin-left:0.mw-parser-output .refbegin-hanging-indents>ul>li,.mw-parser-output .refbegin-hanging-indents>dl>ddmargin-left:0;padding-left:3.2em;text-indent:-3.2em;list-style:none.mw-parser-output .refbegin-100font-size:100%
Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
 | Feniramin na Vikimedijinoj ostavi. |
- Pheniramine
 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
Категорије:
- Антипруритици
- Амини
- Пиридини
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