Paroksetin Садржај Osobine Reference Literatura Spoljašnje veze Мени за навигацијуMonografija61869-08-7WHO43815DB0071539888C07415CHEBI:7936CHEMBL49016272179106277938834412969069211763001„DrugBank 3.0: a comprehensive resource for omics research on drugs”30137092105968210.1093/nar/gkq1126уреди„DrugBank: a knowledgebase for drugs, drug actions and drug targets”22388891804841210.1093/nar/gkm958уреди„Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”10.1021/jp980230o„Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”1174957310.1021/ci000392tуреди„Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”1102028610.1021/jm000942eуредиGoodman & Gilman's The Pharmacological Basis of Therapeutics10.1036/0071422803Foye's Principles of Medicinal ChemistryParoksetinVikimedijinoj ostaviParoxetine
АнтидепресантиСелективни инхибитори преузимања серотонинаЕтриПиперидиниФлуороарени
organsko jedinjenjeatomaugljenikamolekulsku masuDa
(function()var node=document.getElementById("mw-dismissablenotice-anonplace");if(node)node.outerHTML="u003Cdiv class="mw-dismissable-notice"u003Eu003Cdiv class="mw-dismissable-notice-close"u003E[u003Ca tabindex="0" role="button"u003Eсакријu003C/au003E]u003C/divu003Eu003Cdiv class="mw-dismissable-notice-body"u003Eu003Cdiv id="localNotice" lang="sr" dir="ltr"u003Eu003Cdiv style="position:relative; overflow:hidden; background-color:#5E9DC8; text-align:center; color:white; font-size:1.25em; font-weight:bold; line-height:1.5em; margin-top: 5px;"u003Eu003Cuu003Eu003Ca href="/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%A2%D0%B0%D0%BA%D0%BC%D0%B8%D1%87%D0%B5%D1%9A%D0%B5_%D1%83_%D0%BF%D0%B8%D1%81%D0%B0%D1%9A%D1%83_%D1%87%D0%BB%D0%B0%D0%BD%D0%B0%D0%BA%D0%B0/%D0%A6%D0%95%D0%95_%D0%BF%D1%80%D0%BE%D0%BB%D0%B5%D1%9B%D0%B5_2019" title="Википедија:Такмичење у писању чланака/ЦЕЕ пролеће 2019"u003Eu003Cspan style="color:white"u003EТакмичите се у писању чланака о Средњој и Источној Европи од 21. марта до 31. маја!u003C/spanu003Eu003C/au003Eu003C/uu003Eu003C/divu003Enu003Cdiv style="position:relative; overflow:hidden; background-color:#5E9DC8; text-align:center; color:white; font-size:1.25em; font-weight:bold; line-height:1.5em; margin-top: 5px;"u003EУ току је гласање о u003Ca href="/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%93%D0%BB%D0%B0%D1%81%D0%B0%D1%9A%D0%B5/%D0%9E%D0%BC%D0%BE%D0%B3%D1%83%D1%9B%D0%B0%D0%B2%D0%B0%D1%9A%D0%B5_%D0%B4%D0%B5%D0%BB%D0%B8%D0%BC%D0%B8%D1%87%D0%BD%D0%B8%D1%85_%D0%B1%D0%BB%D0%BE%D0%BA%D0%B0%D0%B4%D0%B0" title="Википедија:Гласање/Омогућавање делимичних блокада"u003Eu003Cspan style="color:white"u003Eu003Cuu003Eомогућавању делимичних блокадаu003C/uu003Eu003C/spanu003Eu003C/au003E и u003Ca href="/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%93%D0%BB%D0%B0%D1%81%D0%B0%D1%9A%D0%B5/%D0%9E%D0%BC%D0%BE%D0%B3%D1%83%D1%9B%D0%B0%D0%B2%D0%B0%D1%9A%D0%B5_%D0%92%D0%B8%D0%B7%D1%83%D0%B5%D0%BB%D0%BD%D0%BE%D0%B3_%D1%83%D1%80%D0%B5%D1%92%D0%B8%D0%B2%D0%B0%D1%87%D0%B0_%D1%83_%D0%BF%D1%80%D0%BE%D1%81%D1%82%D0%BE%D1%80%D1%83_%D0%BD%D0%B0%D1%86%D1%80%D1%82%D0%B0" title="Википедија:Гласање/Омогућавање Визуелног уређивача у простору нацрта"u003Eu003Cspan style="color:white"u003Eu003Cuu003EВизуелног уређивача у простору нацртаu003C/uu003Eu003C/spanu003Eu003C/au003E!u003C/divu003Enu003Cdiv style="position:relative; overflow:hidden; background-color:#5E9DC8; text-align:center; color:white; font-size:1.25em; font-weight:bold; line-height:1.5em; margin-top: 5px;"u003Eu003Cuu003Eu003Ca href="/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%93%D0%BB%D0%B0%D1%81%D0%B0%D1%9A%D0%B5/%D0%9F%D1%80%D0%B5%D0%B4%D0%BB%D0%BE%D0%B3/%D0%94%D0%BE%D0%BF%D1%83%D0%BD%D0%B0_%D0%BF%D1%80%D0%B0%D0%B2%D0%B8%D0%BB%D0%B0_%D0%BE_%D0%B8%D0%B7%D0%B0%D0%B1%D1%80%D0%B0%D0%BD%D0%B8%D0%BC_%D1%81%D0%BB%D0%B8%D0%BA%D0%B0%D0%BC%D0%B0" title="Википедија:Гласање/Предлог/Допуна правила о изабраним сликама"u003Eu003Cspan style="color:white"u003EУ току је расправа о допуни правила везаних за изабране слике!u003C/spanu003Eu003C/au003Eu003C/uu003Eu003C/divu003Eu003C/divu003Eu003C/divu003Eu003C/divu003E";());
Paroksetin
Иди на навигацију
Иди на претрагу
 | |
 | |
| Klinički podaci | |
|---|---|
| Prodajno ime | Aropax, Brisdelle, Paxil, Paxil CR |
| Drugs.com | Monografija |
| Način primene | Oralno |
Farmakokinetički podaci | |
| Poluvreme eliminacije | 21-24 h |
| Identifikatori | |
| CAS broj | 61869-08-7  Y |
| ATC kod | N06AB05 (WHO) |
| PubChem | CID 43815 |
| DrugBank | DB00715 Y |
| ChemSpider | 39888 Y |
| KEGG | C07415 Y |
| ChEBI | CHEBI:7936 Y |
| ChEMBL | CHEMBL490 Y |
| Hemijski podaci | |
| Formula | C19H20FNO3 |
| Molarna masa | 329,365 |
SMILES
| |
InChI
| |
| Fizički podaci | |
| Tačka topljenja | 147—150 °C (297—302 °F) |
Paroksetin je organsko jedinjenje, koje sadrži 19 atoma ugljenika i ima molekulsku masu od 329,365 Da.[1][2][3][4][5][6][7]
Садржај
1 Osobine
2 Reference
3 Literatura
4 Spoljašnje veze
Osobine
| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 4 |
| Broj donora vodonika | 1 |
| Broj rotacionih veza | 4 |
Particioni koeficijent[8] (ALogP) | 3,2 |
Rastvorljivost[9] (logS, log(mol/L)) | -4,6 |
Polarna površina[10] (PSA, Å2) | 39,7 |
Reference
^ Baldwin DS, Anderson IM, Nutt DJ, Bandelow B, Bond A, Davidson JR, den Boer JA, Fineberg NA, Knapp M, Scott J, Wittchen HU: Evidence-based guidelines for the pharmacological treatment of anxiety disorders: recommendations from the British Association for Psychopharmacology. J Psychopharmacol. 2005 Nov;19(6):567-96. PMID 16272179
^ Baldwin D, Bobes J, Stein DJ, Scharwachter I, Faure M: Paroxetine in social phobia/social anxiety disorder. Randomised, double-blind, placebo-controlled study. Paroxetine Study Group. Br J Psychiatry. 1999 Aug;175:120-6. PMID 10627793
^ Yonkers KA, Gullion C, Williams A, Novak K, Rush AJ: Paroxetine as a treatment for premenstrual dysphoric disorder. J Clin Psychopharmacol. 1996 Feb;16(1):3-8. PMID 8834412
^ Waldinger MD, Hengeveld MW, Zwinderman AH, Olivier B: Effect of SSRI antidepressants on ejaculation: a double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline. J Clin Psychopharmacol. 1998 Aug;18(4):274-81. PMID 9690692
^ Waldinger MD, Zwinderman AH, Olivier B: SSRIs and ejaculation: a double-blind, randomized, fixed-dose study with paroxetine and citalopram. J Clin Psychopharmacol. 2001 Dec;21(6):556-60. PMID 11763001
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126.
^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889. PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura
.mw-parser-output .refbeginfont-size:90%;margin-bottom:0.5em.mw-parser-output .refbegin-hanging-indents>ullist-style-type:none;margin-left:0.mw-parser-output .refbegin-hanging-indents>ul>li,.mw-parser-output .refbegin-hanging-indents>dl>ddmargin-left:0;padding-left:3.2em;text-indent:-3.2em;list-style:none.mw-parser-output .refbegin-100font-size:100%
Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
 | Paroksetin na Vikimedijinoj ostavi. |
- Paroxetine
 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
Категорије:
- Антидепресанти
- Селективни инхибитори преузимања серотонина
- Етри
- Пиперидини
- Флуороарени
(window.RLQ=window.RLQ||[]).push(function()mw.config.set("wgPageParseReport":"limitreport":"cputime":"1.608","walltime":"2.449","ppvisitednodes":"value":3894,"limit":1000000,"ppgeneratednodes":"value":0,"limit":1500000,"postexpandincludesize":"value":98100,"limit":2097152,"templateargumentsize":"value":3950,"limit":2097152,"expansiondepth":"value":17,"limit":40,"expensivefunctioncount":"value":0,"limit":500,"unstrip-depth":"value":0,"limit":20,"unstrip-size":"value":14094,"limit":5000000,"entityaccesscount":"value":1,"limit":400,"timingprofile":["100.00% 2307.730 1 -total"," 52.80% 1218.571 4 Шаблон:Infobox"," 45.77% 1056.218 1 Шаблон:Drugbox-lat"," 23.28% 537.305 1 Шаблон:Commonscat-lat"," 18.87% 435.451 1 Шаблон:Reflist"," 14.82% 342.052 4 Шаблон:Cite_pmid"," 14.04% 323.933 5 Шаблон:Cite_journal"," 5.91% 136.308 1 Шаблон:Cite_pmid/21059682"," 5.49% 126.612 1 Шаблон:Convert-lat"," 5.36% 123.723 1 Шаблон:Infobox_drug-lat/chemical_formula"],"scribunto":"limitreport-timeusage":"value":"0.645","limit":"10.000","limitreport-memusage":"value":6153760,"limit":52428800,"cachereport":"origin":"mw1338","timestamp":"20190428034745","ttl":2592000,"transientcontent":false););"@context":"https://schema.org","@type":"Article","name":"Paroksetin","url":"https://sr.wikipedia.org/wiki/Paroksetin","sameAs":"http://www.wikidata.org/entity/Q408471","mainEntity":"http://www.wikidata.org/entity/Q408471","author":"@type":"Organization","name":"u0421u0430u0440u0430u0434u043du0438u0446u0438 u043fu0440u043eu0458u0435u043au0430u0442u0430 u0412u0438u043au0438u043cu0435u0434u0438u0458u0435","publisher":"@type":"Organization","name":"Wikimedia Foundation, Inc.","logo":"@type":"ImageObject","url":"https://www.wikimedia.org/static/images/wmf-hor-googpub.png","datePublished":"2013-12-15T06:26:06Z","dateModified":"2017-01-04T06:56:58Z","image":"https://upload.wikimedia.org/wikipedia/commons/3/36/Paroxetine2DACS.svg"(window.RLQ=window.RLQ||[]).push(function()mw.config.set("wgBackendResponseTime":125,"wgHostname":"mw1249"););
