Ribonukleozid-difosfat reduktaza Reference Literatura Spoljašnje veze Мени за навигацију1.17.4.19047-64-7 IntEnz pregledBRENDA pristupNiceZyme pregledKEGG pristupmetabolički putprofilRCSB PDBPDBePDBsumčlancičlanciproteini1.17.4.1454347253301195330120592618416376858Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic ProteinsAdvances in Enzymology and Related Areas of Molecular Biology, Protein EvolutionIntroduction to Protein StructureEnzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme SystemsCatalysis in Chemistry and EnzymologyRibonucleoside-diphosphate+reductaseуу
Superoksid dismutazaSOD1SOD2SOD3Ksantin oksidazaRibonukleozid-difosfat reduktaza4-Hidroksi-3-metilbut-2-enil difosfat reduktazaNitrogenaza (flavodoksin)Izopenicilin-N sintazaKolumbamin oksidazaRetikulin oksidazaSulohrinska oksidaza(+)-bisdehlorogeodin formirajuća(-)-bisdehlorogeodin formirajućaAureuzidin sintazaTetrahidrokanabinolinska kiselina sintazaKanabidiolinska kiselina sintazaHromopirolatna sintaza
ЕЦ 1.17.4
EC1.17.4.1enzimkatalizujehemijsku reakcijuribonukleozid difosfatapopravkugvožđedATP
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Ribonukleozid-difosfat reduktaza
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| Ribonukleozid-difosfat reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.17.4.1 | ||||||||
| CAS broj | 9047-64-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Ribonukleozid-difosfat reduktaza (EC 1.17.4.1, ribonukleotidna reduktaza, CDP reduktaza, ribonukleozidna difosfatna reduktaza, UDP reduktaza, ADP reduktaza, nukleozid difosfatna reduktaza, ribonukleozid 5'-difosfatna reduktaza, ribonukleotidna difosfatna reduktaza, 2'-dezoksiribonukleozid-difosfat:oksidovani-tioredoksin 2'-oksidoreduktaza, RR) je enzim sa sistematskim imenom 2'-dezoksiribonukleozid-difosfat:tioredoksin-disulfid 2'-oksidoreduktaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2'-dezoksiribonukleozid difosfat + tioredoksin disulfid + H2O ⇌displaystyle rightleftharpoons ribonukleozid difosfat + tioredoksin
Ovaj enzim je odgovoran za de novo konverziju ribonukleozid difosfata u dezoksiribonukleozid difosfate, što je esencijalno za DNK sintezu i popravku. On sadrži gvožđe. Enzim aktivira ATP, a inhibira ga dATP.
Reference
^ Lammers, M. & Follmann, H. (1983). „The ribonucleotide reductases - a unique group of metalloenzymes essential for cell-proliferation”. Struct. Bonding. 54: 27—91.
^ Larsson, A. (1973). „Ribonucleotide reductase from regenerating rat liver. II. Substrate phosphorylation level and effect of deoxyadenosine triphosphate”. Biochim. Biophys. Acta. 324: 447—451. PMID 4543472.
^ Larsson, A. & Reichard, P. (1966). „Enzymatic synthesis of deoxyribonucleotides. IX. Allosteric effects in the reduction of pyrimidine ribonucleotides by the ribonucleoside diphosphate reductase system of Escherichia coli”. J. Biol. Chem. 241: 2533—2539. PMID 5330119.
^ Larsson, A. & Reichard, P. (1966). „Enzymatic synthesis of deoxyribonucleotides. X. Reduction of purine ribonucleotides; allosteric behavior and substrate specificity of the enzyme system from Escherichia coli B”. J. Biol. Chem. 241: 2540—2549. PMID 5330120.
^ Moore, E.C. & Hurlbert, R.B. (1966). „Regulation of mammalian deoxyribonucleotide biosynthesis by nucleotides as activators and inhibitors”. J. Biol. Chem. 241: 4802—4809. PMID 5926184.
^ Qiu, W., Zhou, B., Darwish, D., Shao, J. and Yen, Y. (2006). „Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits”. Biochem. Biophys. Res. Commun. 340: 428—434. PMID 16376858. CS1 одржавање: Вишеструка имена: списак аутора (веза)
Literatura
.mw-parser-output .refbeginfont-size:90%;margin-bottom:0.5em.mw-parser-output .refbegin-hanging-indents>ullist-style-type:none;margin-left:0.mw-parser-output .refbegin-hanging-indents>ul>li,.mw-parser-output .refbegin-hanging-indents>dl>ddmargin-left:0;padding-left:3.2em;text-indent:-3.2em;list-style:none.mw-parser-output .refbegin-100font-size:100%
Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
MeSH Ribonucleoside-diphosphate+reductase
Категорија:
- ЕЦ 1.17.4
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