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Hidroksizin Садржај Hemija Reference Literatura Spoljašnje veze Мени за навигацијуМонографијаa68286668-88-2WHO36587199DB00557353130S50YM8OGD08054CHEBI:5818CHEMBL8962866055614119810.1016/0091-6749(84)90486-xBefore Prozac: the troubled history of mood disorders in psychiatryU.S. Patent 2.899.436DE 1049383DE 1061786DE 1068262DE 1072624DE 1075116Before Prozac: the troubled history of mood disorders in psychiatry13385806„MANAGEMENT OF EMOTIONAL DISTURBANCES—Use of Hydroxyzine (Atarax®) in General Practice”151230913536863„Effect of Hydroxyzine on Attention and Memory”10.1002/hup.470050408710342310.1002/ana.410110423„Prevention of "Learned Helplessness" in the Rat by Hydroxyzine”10.1002/ddr.430170306„Acute Effects of Hydroxyzine on Nocturnal Sleep and Sleep Tendency the Following Day: a C-EEG Study”10.1002/hup.470070104„Atarax Indications, Dosage, Storage, Stability”оригинала„Vistaril Oral: Monograph - Hydroxyzine Hydrochloride, Hydroxyzine Pamoate”U.S. National Library of Medicine: Drug Information Portal - Hydroxyzineуууууу

АналгетициАнтиеметициАнксиолитициАнтагонисти Х1 рецептораМускарински антагонистиСедативиПиперазиниХлороарениЕтриАлкохоли


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Hidroksizin




Из Википедије, слободне енциклопедије






Иди на навигацију
Иди на претрагу




















































Hidroksizin (Vistaril, Ataraks) pripada prvoj generaciji antihistamina difenilmetanske i piperazinske klase. On je prvi put sintetisan 1956. i u prodaji je bio od strane kompanije Pfizer u SAD-u iste godine.[3] On je još uvek u širokoj upotrebi.




Садржај





  • 1 Hemija


  • 2 Reference


  • 3 Literatura


  • 4 Spoljašnje veze




Hemija


Hidroksizin se može sintetisati alkilacijom 1-(4-hlorobenzohidril)piperazina sa 2-(2-hidroksietoksi)etilhloridom:[4]


Hydroxyzine synthesis.png


Reference




  1. ↑ 1,01,1 Paton DM, Webster DR (1985). „Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines)”. Clin Pharmacokinet. 10 (6): 477—97. PMID 2866055. 


  2. ^ Simons FE, Simons KJ, Frith EM (јануар 1984). „The pharmacokinetics and antihistaminic of the H1 receptor antagonist hydroxyzine”. The Journal of Allergy and Clinical Immunology. 73 (1 Pt 1): 69—75. PMID 6141198. doi:10.1016/0091-6749(84)90486-x. CS1 одржавање: Формат датума (веза)


  3. ^ Shorter, Edward (2009). Before Prozac: the troubled history of mood disorders in psychiatry. Oxford [Oxfordshire]: Oxford University Press. ISBN 0-19-536874-6. 


  4. ^ H. Morren, U.S. Patent 2.899.436 (1959); H. Morren, DE 1049383  (1954); H. Morren, DE 1061786  (1954); H. Morren, DE 1068262  (1954); H. Morren, DE 1072624  (1954); H. Morren, DE 1075116  (1954).



Literatura


.mw-parser-output .refbeginfont-size:90%;margin-bottom:0.5em.mw-parser-output .refbegin-hanging-indents>ullist-style-type:none;margin-left:0.mw-parser-output .refbegin-hanging-indents>ul>li,.mw-parser-output .refbegin-hanging-indents>dl>ddmargin-left:0;padding-left:3.2em;text-indent:-3.2em;list-style:none.mw-parser-output .refbegin-100font-size:100%


  • Shorter, Edward (2009). Before Prozac: the troubled history of mood disorders in psychiatry. Oxford [Oxfordshire]: Oxford University Press. ISBN 0-19-536874-6. 


  • Hutcheon, D. E.; D.L. Morris; A. Scriabine (1956). „Cardiovascular action of hydroxyzine (Atarax)”. J Pharmacol Exp Ther. 118 (4): 451—460. PMID 13385806. 


  • Dolan, C. M. (1958). „MANAGEMENT OF EMOTIONAL DISTURBANCES—Use of Hydroxyzine (Atarax®) in General Practice”. Calif Med. 88 (6): 443—444. PMC 1512309 Слободан приступ. PMID 13536863. 


  • Pfizer Labs (2004). Vistaril (hydroxyzine pamoate) Capsules and Oral Suspension. United States Food and Drug Administration.  |access-date= захтева |url= (помоћ)


  • Anderson, Philip O.; James E. Knoben; William G. Troutman (2002). Handbook of Clinical Drug Data. McGraw-Hill Medical. ISBN 0-07-136362-9. 


  • de Brabander, A.; W. Deberdt (1990). „Effect of Hydroxyzine on Attention and Memory”. Human Psychopharmacology. John Wiley & Sons. 5 (4): 357—362. doi:10.1002/hup.470050408. Приступљено 9. 3. 2007. [мртва веза]


  • Clark, B. G.; M. Araki; H. W. Brown (1982). „Hydroxyzine-Associated Tardive Dyskinesia”. Ann Neurol. 11 (4): 435. PMID 7103423. doi:10.1002/ana.410110423. 


  • Porsolt, R. D.; P. Martin; et al. (1989). „Prevention of "Learned Helplessness" in the Rat by Hydroxyzine”. Drug Dev. Res. 17 (3): 227—236. doi:10.1002/ddr.430170306. Приступљено 10. 3. 2007. [мртва веза]


  • Alford, C.; N. Rombautt; et al. (1992). „Acute Effects of Hydroxyzine on Nocturnal Sleep and Sleep Tendency the Following Day: a C-EEG Study”. Human Psychopharmacology. 7 (1): 25—35. doi:10.1002/hup.470070104. Приступљено 10. 3. 2007. [мртва веза]


  • RxList; et al. (2004). „Atarax Indications, Dosage, Storage, Stability”. RxList - The internet drug index. Архивирано из оригинала на датум 27. 02. 2007. Приступљено 9. 3. 2007. 


  • Medscape (2004). „Vistaril Oral: Monograph - Hydroxyzine Hydrochloride, Hydroxyzine Pamoate”. medscape.com. Приступљено 9. 3. 2007. 



Spoljašnje veze


  • U.S. National Library of Medicine: Drug Information Portal - Hydroxyzine
Hidroksizin
Hydroxyzine.svg
Hydroxyzine-3d-sticks.png

IUPAC ime
(±)-2-(2-4-[(4-hlorofenil)-fenilmetil]piperazin-1-iletoksi)etanol
Klinički podaci
Prodajno imeAtaraks, Vistaril, drugi
Drugs.comМонографија
MedlinePlusa682866
Kategorija trudnoće


  • AU: A


  • US: C (Mogući rizik)


Način primene
oralno, intramaskularno
Pravni status
Pravni status


  • AU: S4 (Prescription only)

  • ℞ (Prescription only)



Farmakokinetički podaci
Bioraspoloživostvisoka
Vezivanje proteina93%
Metabolizamhepati;ki
Metaboliti
Cetirizin, drugi
Poluvreme eliminacijeOdrasli: 20,0 sata[1][2]
Deca: 7,1 sati[1]
Izlučivanje
Urin, fekalije

Identifikatori
CAS broj
68-88-2 ДаY
2192-20-3 (dihidrohlorid)
10246-75-0 (pamoat)
ATC kod
N05BB01 (WHO)
PubChemCID 3658
IUPHAR/BPS7199
DrugBank
DB00557 ДаY
ChemSpider
3531 ДаY
UNII
30S50YM8OG ДаY
KEGG
D08054 ДаY
ChEBI
CHEBI:5818 ДаY
ChEMBL
CHEMBL896 ДаY
SinonimiUCB-4492
Hemijski podaci
Formula
C21H27ClN2O2
Molarna masa374.904 g/mol

























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