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Tofizopam Садржај Osobine Reference Literatura Spoljašnje veze Мени за навигацијуMonografija22345-47-7WHO5502DB088115301CHEBI:518452CHEMBL40421620967473„DrugBank 3.0: a comprehensive resource for omics research on drugs”30137092105968210.1093/nar/gkq1126уреди„DrugBank: a knowledgebase for drugs, drug actions and drug targets”22388891804841210.1093/nar/gkm958уреди„Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”10.1021/jp980230o„Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”1174957310.1021/ci000392tуреди„Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”1102028610.1021/jm000942eуредиGoodman & Gilman's The Pharmacological Basis of Therapeutics10.1036/0071422803Foye's Principles of Medicinal ChemistryTofizopamVikimedijinoj ostaviTofisopam

ФенолиФенолни етри


organsko jedinjenjeatomaugljenikamolekulsku masuDa










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Tofizopam




Из Википедије, слободне енциклопедије

(преусмерено са Tofisopam)





Иди на навигацију
Иди на претрагу





























Tofizopam
Tofisopam structure.svg
Tofisopam3d.png
Klinički podaci
Prodajno imeEmandaxin, Grandaxin, Seriel
Drugs.comMonografija

Farmakokinetički podaci
Poluvreme eliminacije6-8 h

Identifikatori
CAS broj
22345-47-7 ДаY
ATC kod
N05BA23 (WHO)
PubChemCID 5502
DrugBank
DB08811 ДаY
ChemSpider
5301 ДаY
ChEBI
CHEBI:518452 ДаY
ChEMBL
CHEMBL404216 ДаY
Hemijski podaci
Formula
C22H26N2O4
Molarna masa382,453



Fizički podaci
Tačka topljenja
1.565 °C (2.849 °F)

Tofizopam je organsko jedinjenje, koje sadrži 22 atoma ugljenika i ima molekulsku masu od 382,453 Da.[1][2][3]




Садржај





  • 1 Osobine


  • 2 Reference


  • 3 Literatura


  • 4 Spoljašnje veze




Osobine
















OsobinaVrednost
Broj akceptora vodonika6
Broj donora vodonika0
Broj rotacionih veza6

Particioni koeficijent[4] (ALogP)
4,2

Rastvorljivost[5] (logS, log(mol/L))
-6,3

Polarna površina[6] (PSA, Å2)
61,6


Reference




  1. ^ Rundfeldt C, Socala K, Wlaz P: The atypical anxiolytic drug, tofisopam, selectively blocks phosphodiesterase isoenzymes and is active in the mouse model of negative symptoms of psychosis. J Neural Transm. 2010 Nov;117(11):1319-25. Epub 2010 Oct 22. PMID 20967473


  2. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 Слободан приступ. PMID 21059682. doi:10.1093/nar/gkq1126.  уреди


  3. ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 Слободан приступ. PMID 18048412. doi:10.1093/nar/gkm958.  уреди


  4. ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 


  5. ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.  уреди


  6. ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.  уреди



Literatura


.mw-parser-output .refbeginfont-size:90%;margin-bottom:0.5em.mw-parser-output .refbegin-hanging-indents>ullist-style-type:none;margin-left:0.mw-parser-output .refbegin-hanging-indents>ul>li,.mw-parser-output .refbegin-hanging-indents>dl>ddmargin-left:0;padding-left:3.2em;text-indent:-3.2em;list-style:none.mw-parser-output .refbegin-100font-size:100%


  • Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803. 


  • Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799. 



Spoljašnje veze





  • Tofisopam


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