Adinazolam Садржај Osobine Reference Literatura Spoljašnje veze Мени за навигацијуMonografija37115-32-5WHO37632DB0054634519CHEBI:251412CHEMBL328250632003661484002867497„DrugBank 3.0: a comprehensive resource for omics research on drugs”30137092105968210.1093/nar/gkq1126„DrugBank: a knowledgebase for drugs, drug actions and drug targets”22388891804841210.1093/nar/gkm958„Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”10.1021/jp980230o„Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”1174957310.1021/ci000392t„Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”1102028610.1021/jm000942eGoodman & Gilman's The Pharmacological Basis of Therapeutics10.1036/0071422803Foye's Principles of Medicinal ChemistryAdinazolamVikimedijinoj ostaviAdinazolam
АнксиолитициАминиХлороарениДизајниране дроге
organsko jedinjenjeatomaugljenikamolekulsku masuDa
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Adinazolam
Иди на навигацију
Иди на претрагу
 | |
 | |
| Klinički podaci | |
|---|---|
| Drugs.com | Monografija |
Farmakokinetički podaci | |
| Poluvreme eliminacije | 3 h |
| Identifikatori | |
| CAS broj | 37115-32-5  Y |
| ATC kod | N05BA07 (WHO) |
| PubChem | CID 37632 |
| DrugBank | DB00546 Y |
| ChemSpider | 34519 Y |
| ChEBI | CHEBI:251412 Y |
| ChEMBL | CHEMBL328250 Y |
| Hemijski podaci | |
| Formula | C19H18ClN5 |
| Molarna masa | 351,833 |
SMILES
| |
InChI
| |
Adinazolam je organsko jedinjenje, koje sadrži 19 atoma ugljenika i ima molekulsku masu od 351,833 Da.[1][2][3][4][5]
Садржај
1 Osobine
2 Reference
3 Literatura
4 Spoljašnje veze
Osobine
| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 4 |
| Broj donora vodonika | 0 |
| Broj rotacionih veza | 3 |
Particioni koeficijent[6] (ALogP) | 3,5 |
Rastvorljivost[7] (logS, log(mol/L)) | -5,6 |
Polarna površina[8] (PSA, Å2) | 46,3 |
Reference
^ Lahti RA, Sethy VH, Barsuhn C, Hester JB: Pharmacological profile of the antidepressant adinazolam, a triazolobenzodiazepine. Neuropharmacology. 1983 Nov;22(11):1277-82. PMID 6320036
^ Sethy VH, Collins RJ, Daniels EG: Determination of biological activity of adinazolam and its metabolites. J Pharm Pharmacol. 1984 Aug;36(8):546-8. PMID 6148400
^ File SE, Pellow S: Triazolobenzodiazepines antagonize the effects of anxiogenic drugs mediated at three different central nervous system sites. Neurosci Lett. 1985 Oct 24;61(1-2):115-9. PMID 2867497
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126.
^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889. PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura
.mw-parser-output .refbeginfont-size:90%;margin-bottom:0.5em.mw-parser-output .refbegin-hanging-indents>ullist-style-type:none;margin-left:0.mw-parser-output .refbegin-hanging-indents>ul>li,.mw-parser-output .refbegin-hanging-indents>dl>ddmargin-left:0;padding-left:3.2em;text-indent:-3.2em;list-style:none.mw-parser-output .refbegin-100font-size:100%
Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
 | Adinazolam na Vikimedijinoj ostavi. |
- Adinazolam
 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
Категорије:
- Анксиолитици
- Амини
- Хлороарени
- Дизајниране дроге
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