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Lorazepam Reference Spoljašnje veze Мени за навигацијуMonografija846-49-1WHO3958DB00186382174390586144459862566623854836113982105968218048412LorazepamVikimedijinoj ostaviLorazepamу

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benzodiazepinanksioznostiMDIGtgpphysdevpenzynococongtumrsysieponprocdrugA2A2B345671416blte










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Lorazepam




Из Википедије, слободне енциклопедије






Иди на навигацију
Иди на претрагу





























Lorazepam
Lorazepam.svg
Lorazepam3Dan.gif

IUPAC ime
7-hloro-5-(2-hlorofenil)-3-hidroksi-2,3-dihidro-1H-1,4-benzodiazepin-2-on
Klinički podaci
Prodajno imeAlmazine, Alzapam, Anxiedin, Aplacassee
Drugs.comMonografija
Način primeneParenteralno; Oralno

Farmakokinetički podaci
Poluvreme eliminacije14±5 sati (Parenteralno)
Izlučivanje88% urinom

Identifikatori
CAS broj
846-49-1 ДаY
ATC kod
N05BA06 (WHO)
PubChemCID 3958
DrugBank
DB00186 ДаY
ChemSpider
3821 ДаY
Hemijski podaci
Formula
C15H10Cl2N2O2
Molarna masa321.158



Fizički podaci
Tačka topljenja
167 °C (333 °F)

Lorazepam je benzodiazepin koji se koristi kao agens protiv anksioznosti sa malim brojem nuspojava. On takođe ima hipnotička, antikonvulsivna, u znatna sedativna svojstva.[1][2][3][4][5][6][7]



Reference




  1. ^ Kemper N, Poser W, Poser S: [Benzodiazepine dependence: addiction potential of the benzodiazepines is greater than previously assumed (author's transl)] Dtsch Med Wochenschr. 1980 Dec 5;105(49):1707-12. PMID 7439058


  2. ^ Lader M: Short-term versus long-term benzodiazepine therapy. Curr Med Res Opin. 1984;8 Suppl 4:120-6. PMID 6144459


  3. ^ Maltais F, Laberge F, Laviolette M: A randomized, double-blind, placebo-controlled study of lorazepam as premedication for bronchoscopy. Chest. 1996 May;109(5):1195-8. PMID 8625666


  4. ^ Heisterkamp DV, Cohen PJ: The effect of intravenous premedication with lorazepam (ativan), pentobarbitone or diazepam on recall. Br J Anaesth. 1975 Jan;47(1):79-81. PMID 238548


  5. ^ Milligan DW, Howard MR, Judd A: Premedication with lorazepam before bone marrow biopsy. J Clin Pathol. 1987 Jun;40(6):696-8. PMID 3611398


  6. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMID 21059682. 


  7. ^ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (Nucleic Acids Res) (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. 36 (Database issue): D901—6. PMID 18048412. CS1 одржавање: Вишеструка имена: списак аутора (веза)



Spoljašnje veze





  • Lorazepam



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