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Alfa-1 adrenergički receptor Садржај Efekti Ligandi Vidi još Literatura Spoljašnje veze Мени за навигацију„Coronary vasoconstriction mediated by α1- and α2-adrenoceptors in conscious dogs”2887122оригинала928037110.1046/j.1365-2885.1997.00078.x„Involvement of α1 and α2 adrenoceptors in the postlaparotomy intestinal motor disturbances in the rat”1433140288964910.1136/gut.28.8.955„Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety”24299011850557610.1186/1754-9493-2-13„Adrenoceptors”уу

Адренергички рецепториГ протеин спрегнути рецептори


G protein-spregnuti receptorGqheterotrimerni G proteinα1A-α1B-α1D-Kateholamininorepinefrinepinefrincentralnomperifernomα2-adrenergičkiglatke mišićeantidepresiviantipsihotici










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Alfa-1 adrenergički receptor




Из Википедије, слободне енциклопедије






Иди на навигацију
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Alfa-1 (α1) adrenergički receptor je G protein-spregnuti receptor koji vezuje Gq heterotrimerni G protein. Postoje tri visoko homologna podtipa, α1A-, α1B-, i α1D- adrenergički receptor. Kateholamini kao što su norepinefrin (noradrenalin) i epinefrin (adrenalin) prenose signal kroz α1-adrenergički receptor u centralnom i perifernom nervnom sistemu.




Садржај





  • 1 Efekti

    • 1.1 Opšti


    • 1.2 Specifični



  • 2 Ligandi


  • 3 Vidi još


  • 4 Literatura


  • 5 Spoljašnje veze




Efekti


α1 i α2-adrenergički receptori imaju nekoliko zajedničkih opštih funkcija, ali isto tako i niz specifičnih efekata.



Opšti


Zajednički (ili još uvek neodređeni) efekti su:



  • Vazokonstrikcija arterija ka srcu (koronarnih arterija)[1]

  • Vazokonstrikcija vena[2]

  • Umanjena motilnost glatkih mišića gastrointestinalnog trakta[3]


Specifični


Primarni efekat je na glatke mišiće. Aktivacija ovog receptora izaziva njihovu konstrikciju. Međutim, postoji i niz drugih funkcija.



Ligandi





Razni heterociklični antidepresivi i antipsihotici su isto tako antagonisti α1-adrenergičkog receptora. Ovo dejstvo je generalno nepoželjno kod takvih agenasa.



Vidi još


  • Adrenergički receptor


Literatura




  1. ^ Woodman OL, Vatner SF (1987). „Coronary vasoconstriction mediated by α1- and α2-adrenoceptors in conscious dogs”. Am. J. Physiol. 253 (2 Pt 2): H388—93. PMID 2887122. Архивирано из оригинала на датум 17. 05. 2010. Приступљено 11. 02. 2011. 


  2. ^ Elliott J (1997). „Alpha-adrenoceptors in equine digital veins: evidence for the presence of both α1 and α2-receptors mediating vasoconstriction”. J. Vet. Pharmacol. Ther. 20 (4): 308—17. PMID 9280371. doi:10.1046/j.1365-2885.1997.00078.x. 


  3. ^ Sagrada A, Fargeas MJ, Bueno L (1987). „Involvement of α1 and α2 adrenoceptors in the postlaparotomy intestinal motor disturbances in the rat”. Gut. 28 (8): 955—9. PMC 1433140 Слободан приступ. PMID 2889649. doi:10.1136/gut.28.8.955. 


  4. ^ Fahed S, Grum DF, Papadimos TJ (2008). „Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety”. Patient Saf Surg. 2: 13. PMC 2429901 Слободан приступ. PMID 18505576. doi:10.1186/1754-9493-2-13. 




Spoljašnje veze



  • „Adrenoceptors”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 










Преузето из „https://sr.wikipedia.org/w/index.php?title=Alfa-1_adrenergički_receptor&oldid=20826360”










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