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Bromazin Osobine Reference Spoljašnje veze Мени за навигацијуa6820651808-12-41808-12-4WHO2444DB012372350202J683U97CHEBI:59177CHEMBL1201245Goodman & Gilman's The Pharmacological Basis of Therapeutics10.1036/0071422803PDR: Physicians Desk Reference 2010 (Physicians' Desk Reference (Pdr))„Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”10.1021/jp980230o„Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”1174957310.1021/ci000392t„Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”1102028610.1021/jm000942eууу

Антагонисти Х1 рецептораОрганобромидиЕтриАмиди


antihistaminikantiholinergikhalogenovanaAkrivastinAlinastinAstemizolAzelastinBamirastinBarmastinBepiastinBepotastinBilastinKabastinenKarebastinKetirizinKlemastinKlemizolKlobenztropinDorastinEbastinEmedastinEpinastinFlezelastinKetotifenLatrepirdinLevokabastinLinetastinLoratadinMapinastinMebhidrolinMizolastinMoksastinNoberastinOktastinOlopatadinPerastinPiklopastinRokastinRupatadinSetastinTalastinTemelastinTerfenadinZepastinDesloratadinFeksofenadinCetirizin‎‎LevocetirizinBelarizinEfletirizinElbanizinFlotrenizinMedrilaminNapaktadinPibaksizinTagorizinTrelnarizinTrenizinVapitadinMPSOPSImeprdsrdodbpasspecspvoprocN5A5B5C6A6B6D










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Bromazin




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Bromazin
Bromazine.svg

IUPAC ime
2-[(4-bromofenil)-fenilmetoksi]-N,N-dimetiletanamin
Klinički podaci
MedlinePlusa682065
Način primeneOralno

Farmakokinetički podaci
Bioraspoloživostvisoka
Vezivanje proteina96%
MetabolizamUglavnom hepatički (CYP-posredovano), takođe renalno
Poluvreme eliminacije1 do 4 sata

Identifikatori
CAS broj
1808-12-4 ДаY1808-12-4
ATC kod
R06AA01 (WHO)
PubChemCID 2444
DrugBank
DB01237 ДаY
ChemSpider
2350 ДаY
UNII
202J683U97 ДаY
ChEBI
CHEBI:59177 ДаY
ChEMBL
CHEMBL1201245 ДаY
Hemijski podaci
Formula
C17H20BrNO
Molarna masa334,251 g/mol



Bromazin (Ambrodil, bromodifenhidramin) je antihistaminik i antiholinergik. On je halogenovana forma difenhidramina i u mnogim pogledima je nešto jače dejstvo.[1][2]



Osobine
















OsobinaVrednost
Broj akceptora vodonika2
Broj donora vodonika0
Broj rotacionih veza6

Particioni koeficijent[3] (ALogP)		4,1

Rastvorljivost[4] (logS, log(mol/L))		-5,5

Polarna površina[5] (PSA, Å2)		12,5


Reference




  1. ^ Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803. 


  2. ^ Pdr Staff (2009). PDR: Physicians Desk Reference 2010 (Physicians' Desk Reference (Pdr)). Rozelle, N.S.W: Thomson Reuters. ISBN 1-56363-748-0. 


  3. ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 


  4. ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 


  5. ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 



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