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SB-408,124 Literatura Spoljašnje veze Мени за навигацију288150-92-5„Characterisation of the binding of 3H-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor”15741971469105510.1038/sj.bjp.07056101847770410.1152/ajpendo.90243.2008уу

СедативиОрексински антагонистиХинолиниОрганофосфатиУреје


oreksinskog receptoraOX1OX2biodostupnostSB-334,867MPSOPSImeprdsrdodbpasspecspvoprocN5A5B5C6A6B6D










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SB-408,124




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SB-408,124
SB408124 structure.png

IUPAC ime
N-(6,8-Difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]urea
Identifikatori
CAS broj288150-92-5
Hemijski podaci
Formula
C19H18F2N4O
Molarna masa356.368 g/mol



SB-408,124 je lek koji je ne-peptidni selektivni antagonist oreksinskog receptora, tipa OX1. On je oko 70 puta selektivniji za OX1 nego OX2 receptor, ima poboljšanu oralnu biodostupnost u poređenju sa starijim OX1 antagonistom SB-334,867. On se koristi u naučnim istraživanjima funkcije oreksinergičkih neurona u telu.[1][2]



Literatura




  1. ^ Langmead, CJ; Jerman, JC; Brough, SJ; Scott, C; Porter, RA; Herdon, HJ (2004). „Characterisation of the binding of 3H-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor”. British journal of pharmacology. 141 (2): 340—6. PMC 1574197 Слободан приступ. PMID 14691055. doi:10.1038/sj.bjp.0705610. 


  2. ^ Peng, HY; Chang, HM; Chang, SY; Tung, KC; Lee, SD; Chou, D; Lai, CY; Chiu, CH; Chen, GD (2008). „Orexin-A modulates glutamatergic NMDA-dependent spinal reflex potentiation via inhibition of NR2B subunit”. American journal of physiology. Endocrinology and metabolism. 295 (1): E117—29. PMID 18477704. doi:10.1152/ajpendo.90243.2008. 



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