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SB-649,868 Reference Spoljašnje veze Мени за навигацију25195495CHEMBL1272307„Clinical trials to evaluate the effects of SB-649868 (10, 30 mg and 60 mg) on subjects with primary insomnia”„Almorexant in Adult Subjects With Chronic Primary Insomnia (RESTORA 1), ClinicalTrials.gov”уу

СедативиОрексински антагонисти


oreksinskogGlaksoSmitKlajnACT-078573MPSOPSImeprdsrdodbpasspecspvoprocN5A5B5C6A6B6D










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SB-649,868




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SB-649,868
SB649868 structure.png

IUPAC ime
N-([(2S)-1-([5-(4-fluorofenil)-2-metil-4-tiazolil]karbonil)-2-piperidinil]metil)-4-benzofurankarboksamid
Identifikatori
ATC kodnone
PubChemCID 25195495
ChEMBLCHEMBL1272307
Hemijski podaci
Formula
C26H24FN3O3S
Molarna masa477,549 g/mol (slobodna baza)



SB-649,868 je antagonist oreksinskog receptora u razvoju od strane kompanije GlaksoSmitKlajn. Ovaj lek je u fazi 2 kliničkih ispitivanja za poremećaje spavanja.[1]


Ovaj lek je sličan ACT-078573, koji je razio Aktelion. GlaksoSmitKlajn je prekinuo dalja klinička ispitivanja almoreksanta zbog nuspojava.[2]



Reference




  1. ^ „Clinical trials to evaluate the effects of SB-649868 (10, 30 mg and 60 mg) on subjects with primary insomnia”. 


  2. ^ „Almorexant in Adult Subjects With Chronic Primary Insomnia (RESTORA 1), ClinicalTrials.gov”. Приступљено 3. 02. 2010. 



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