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Almoreksant Садржај Mehanizam akcije Klinička upotreba Vidi još Literatura Spoljašnje veze Мени за навигацију871224-64-52372768921377865„Almorexant in Adult Subjects With Chronic Primary Insomnia (RESTORA 1), ClinicalTrials.gov”„Actelion and GSK Discontinue Clinical Development of Almorexant”оригиналаZvanični sajt kompanije Actelionуу

СедативиОрексински антагонистиТетрахидроизохинолиниФенолни етриАцетамидиОрганофлуориди


INNantagonistoreksinskihActelioninsomnijeklinička ispitivanja20092011nesaniceMPSOPSImeprdsrdodbpasspecspvoprocN5A5B5C6A6B6D










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Almoreksant




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Almoreksant
Almorexant.svg

IUPAC ime
(2R)-2-[(1S)- 6,7-dimethoxy- 12-[4-(trifluoromethyl)phenyl]ethyl 3,4-dihydroisoquinolin-2(1H)-yl]- N-methyl- 2-phenylacetamide
Klinički podaci
Način primeneOralno

Farmakokinetički podaci
MetabolizamHepatčki

Identifikatori
CAS broj
871224-64-5 ДаY
ATC kodnone
PubChemCID 23727689
ChemSpider
21377865 ДаY
Hemijski podaci
Formula
C29H32ClF3N2O3
Molarna masa512,6 g/mol (slobodna baza)



Almoreksant (INN), kode ACT-078573, je kompetitivni antagonist OX1 i OX2oreksinskih receptor. Ovaj lek je razvila farmaceutska kompanija Actelion za lečenje primarne insomnije. Njegova klinička ispitivanja faze III su završen su novembra 2009.[1]


Januara 2011 Actelion i GSK su objavili prestanak daljih kliničkih ispitivanja zbog nuspojava.[2]




Садржај





  • 1 Mehanizam akcije


  • 2 Klinička upotreba


  • 3 Vidi još


  • 4 Literatura


  • 5 Spoljašnje veze




Mehanizam akcije


Almoreksant je kompetitivni, dualni antagonist receptora OX1 i OX2. On selektivno inhibira aktivaciju OX1 i OX2 receptora.



Klinička upotreba


Almoreksant je bio u razvoju za lečenje nesanice.



Vidi još


  • SB-649,868


Literatura




  1. ^ „Almorexant in Adult Subjects With Chronic Primary Insomnia (RESTORA 1), ClinicalTrials.gov”. Приступљено 3. 02. 2010. 


  2. ^ „Actelion and GSK Discontinue Clinical Development of Almorexant”. Архивирано из оригинала на датум 03. 03. 2011. Приступљено 22. 04. 2011. .



Spoljašnje veze



  • Zvanični sajt kompanije Actelion





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