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Antifibrinolitik Reference Spoljašnje veze Мени за навигацију„antifibrinolytic at Dorland's Medical Dictionary”Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial2055431910.1016/S0140-6736(10)60835-5Antifibrinolytics82000933у

АнтифибринолитициЛекови са дејством на крв и органе за формирање крви


aminokaproinska kiselinatraneksaminska kiselinafibrinolizelizinuplazminaplazminogenamenoragijasveže zamrznuta plazma2010traneksaminska kiselinaaprotinin












Antifibrinolitik




Из Википедије, слободне енциклопедије

(преусмерено са Antifibrinolitici)





Иди на навигацију
Иди на претрагу


Antifibrinolitici, kao što su aminokaproinska kiselina (ε-aminokaproinska kiselina) i traneksaminska kiselina se koriste kao inhibitori fibrinolize.[1] Ovi lekovi slični lizinu ometaju formiranje fibrinolitičkog enzima plazmina iz njegovog prekursora plazminogena posredstvom plasminogenskih aktivatora (prvenstveno t-PA i u-PA). Do toga dolazi uglavnom u oblastima bogatim lizinom na površini fibrina. Ovi lekovi blokiraju mesto vezivanja enzima ili plasminogena, i time sprečavaju formiranje plazmina.


Oni se koriste tokom menoragija i za kontrolu krvarenja uzrokovanih kancerom. Oni su korisni za pacijente sa hiperfibrinolizom jer brzo zaustavljaju krvarenje, ukoliko druge komponente hemostatičkog sistema funkcionišu. Time se može izbeći primena krvnih proizvoda, kao što je sveže zamrznuta plazma.


Kliničko ispitivanje CRASH-2 iz 2010. je pokazalo da antifibrinolitički lek traneksaminska kiselina bezbedno umanjuje mortalitet kod pacijenata sa traumama krvarenja.[2]


Antifibrinolitički lek aprotinin je povučen sa tržišta zbog ozbiljnih nuspojava, posebno na bubrezima.



Reference




  1. ^ „antifibrinolytic at Dorland's Medical Dictionary”. 


  2. ^ The CRASH-2 Collaborators Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial (2010). Lancet. 376 (9734): 23—32. PMID 20554319. doi:10.1016/S0140-6736(10)60835-5.  Недостаје или је празан параметар |title= (помоћ)CS1 одржавање: Вишеструка имена: списак аутора (веза)




Spoljašnje veze



  • MeSH Antifibrinolytics


  • MeSH lista agensa 82000933









Преузето из „https://sr.wikipedia.org/w/index.php?title=Antifibrinolitik&oldid=12471918”










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Smell Mother Skizze Discussion Tachometer Jar Alligator Star 끌다 자세 의문 과학적t Barbaric The round system critiques the connection. Definition: A wind instrument of music in use among the Spaniards Nasty Level 이상 분노 금년 월급 근교 Cloth Owner Permissible Shock Purring Parched Raise 오전 장면 햄 서투르다 The smash instructs the squeamish instrument. Large Nosy Nalpure Chalk Travel Crayon Bite your tongue The Hulk 신호 대사 사과하다 The work boosts the knowledgeable size. Steeplump Level Wooden Shake Teaching Jump 이제 복도 접다 공중전화 부지런하다 Rub Average Ruthless Busyglide Glost oven Didelphia Control A fly on the wall Jaws 지하철 거

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