Skip to main content

Aprotinin Reference Literatura Spoljašnje veze Мени за навигацијуMonografija9087-70-1WHODB0669204XPW8C0FLD02971CHEMBL1201619„Bayer Temporarily Suspends Global Trasylol Marketing”оригинала„European Medicines Agency recommends lifting suspension of aprotinin”15277296Goodman & Gilman's The Pharmacological Basis of Therapeutics10.1036/0071422803Foye's Principles of Medicinal ChemistryAprotininVikimedijinoj ostaviAprotinin

Лекови повучени с тржиштаАнтифибринолитици


Bayertripsinenzimelekkrvarenjaoperacijafibrinolizetransfuzijama krvihipotenzije20072012Evropske medicinske agencije












Aprotinin




Из Википедије, слободне енциклопедије






Иди на навигацију
Иди на претрагу





























Aprotinin
Aprotinin.png
Klinički podaci
Drugs.comMonografija
Način primeneIntraarterijalno

Farmakokinetički podaci
Poluvreme eliminacije150 minuta
IzlučivanjeRenalno

Identifikatori
CAS broj
9087-70-1 ДаY
ATC kod
B02AB01 (WHO)
DrugBank
DB06692 ДаY
UNII
04XPW8C0FL ДаY
KEGG
D02971 ДаY
ChEMBL
CHEMBL1201619 ДаY
SinonimiTrasylol, bovine pancreatic trypsin inhibitor
Hemijski podaci
Formula
C284H432N84O79S7
Molarna masa6511,51 g/mol

Aprotinin (Trasylol, Bayer), je mali protein inhibitor goveđeg pankreatičkog tripsina, ili BPTI, koji inhibira tripsin i srodne proteolitičke enzime. Pod prodajnim imenom Trasylol, aprotinin je korišten kao lek za redukovanje krvarenja tokom kompleksnih operacija, kao što su operacije srca i jetre. Njegovo glavno dejstvo je usporavanje fibrinolize, procesa koji dovodi do razlaganja krvnih ugrušaka. Svrha njegove primene je smanjenje potrebe za transfuzijama krvi tokom operacija, kao i oštećenja organa usled hipotenzije (niskog krvnog pritiska). Lek je privremeno povučen sa tržišta 2007, nakon što je ustanovljeno da njegova primena povišava rizik od komplikacija i smrti,[1] što je potvđeno naknadnim studijama. Prodaja trasilola je obustavljena maja 2008, izuzev za veoma ograničenu istraživačku upotrebu. Februara 2012, naučni odbor Evropske medicinske agencije (EMA) je poništio svoj prethodni stav o aprotinina, i preporučio je ukidanje suspenzije primene ovog leka.[2][3]



Reference




  1. ^ „Bayer Temporarily Suspends Global Trasylol Marketing” (PDF) (Саопштење). Trasylol.com. 5. 11. 2007. Архивирано из оригинала (PDF) на датум 17. 07. 2011. Приступљено 3. 12. 2007. 


  2. ^ „European Medicines Agency recommends lifting suspension of aprotinin”. European Medicines Agency. 17. 2. 2012. 


  3. ^ Mahdy AM, Webster NR: Perioperative systemic haemostatic agents. Br J Anaesth. 2004 Dec;93(6):842-58. Epub 2004 Jul 26. PMID 15277296



Literatura


.mw-parser-output .refbeginfont-size:90%;margin-bottom:0.5em.mw-parser-output .refbegin-hanging-indents>ullist-style-type:none;margin-left:0.mw-parser-output .refbegin-hanging-indents>ul>li,.mw-parser-output .refbegin-hanging-indents>dl>ddmargin-left:0;padding-left:3.2em;text-indent:-3.2em;list-style:none.mw-parser-output .refbegin-100font-size:100%


  • Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803. 


  • Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799. 



Spoljašnje veze





  • Aprotinin


Star of life.svgMolimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).








Преузето из „https://sr.wikipedia.org/w/index.php?title=Aprotinin&oldid=20743081”










Мени за навигацију


























(RLQ=window.RLQ||[]).push(function()mw.config.set("wgPageParseReport":"limitreport":"cputime":"0.444","walltime":"0.632","ppvisitednodes":"value":3386,"limit":1000000,"ppgeneratednodes":"value":0,"limit":1500000,"postexpandincludesize":"value":40363,"limit":2097152,"templateargumentsize":"value":2663,"limit":2097152,"expansiondepth":"value":17,"limit":40,"expensivefunctioncount":"value":0,"limit":500,"unstrip-depth":"value":0,"limit":20,"unstrip-size":"value":3331,"limit":5000000,"entityaccesscount":"value":1,"limit":400,"timingprofile":["100.00% 563.463 1 -total"," 45.05% 253.864 1 Шаблон:Drugbox-lat"," 38.37% 216.174 3 Шаблон:Infobox"," 24.44% 137.725 1 Шаблон:Commonscat-lat"," 14.93% 84.153 1 Шаблон:Reflist"," 11.56% 65.147 1 Шаблон:Commons-lat"," 9.97% 56.159 1 Шаблон:Cite_press_release"," 5.99% 33.747 1 Шаблон:Infobox_drug-lat/chemical_formula"," 4.57% 25.733 2 Шаблон:Cite_book"," 3.78% 21.327 2 Шаблон:Keypress"],"scribunto":"limitreport-timeusage":"value":"0.160","limit":"10.000","limitreport-memusage":"value":3405518,"limit":52428800,"cachereport":"origin":"mw1329","timestamp":"20190625211407","ttl":2592000,"transientcontent":false););"@context":"https://schema.org","@type":"Article","name":"Aprotinin","url":"https://sr.wikipedia.org/wiki/Aprotinin","sameAs":"http://www.wikidata.org/entity/Q418625","mainEntity":"http://www.wikidata.org/entity/Q418625","author":"@type":"Organization","name":"u0421u0430u0440u0430u0434u043du0438u0446u0438 u043fu0440u043eu0458u0435u043au0430u0442u0430 u0412u0438u043au0438u043cu0435u0434u0438u0458u0435","publisher":"@type":"Organization","name":"Wikimedia Foundation, Inc.","logo":"@type":"ImageObject","url":"https://www.wikimedia.org/static/images/wmf-hor-googpub.png","datePublished":"2013-12-19T19:59:31Z","dateModified":"2018-08-22T00:48:44Z","image":"https://upload.wikimedia.org/wikipedia/commons/3/34/Aprotinin.png"(RLQ=window.RLQ||[]).push(function()mw.config.set("wgBackendResponseTime":135,"wgHostname":"mw1245"););
-

Popular posts from this blog

19. јануар Садржај Догађаји Рођења Смрти Празници и дани сећања Види још Референце Мени за навигацијуу

Image
1.2.3.4.5.6.7.8.9.10.11.12.13.14.15.16.17.18.19.20.21.22.23.24.25.26.27.28.29.30.31.1.2.3.4.5.6.7.8.9.10.11.12.13.14.15.16.17.18.19.20.21.22.23.24.25.26.27.28.29.30.31.1.2.3.4.5.6.7.8.9.10.11.12.13.14.15.16.17.18.19.20.21.22.23.24.25.26.27.28.29.30.31.1.2.3.4.5.6.7.8.9.10.11.12.13.14.15.16.17.18.19.20.21.22.23.24.25.26.27.28.29.30.31.1.2.3.4.5.6.7.8.9.10.11.12.13.14.15.16.17.18.19.20.21.22.23.24.25.26.27.28.29.30.1.2.3.4.5.6.7.8.9.10.11.12.13.14.15.16.17.18.19.20.21.22.23.24.25.26.27.28.29.30. ЈануарДани деветнаестиГрегоријанском календарупреступним годинама (function()var node=document.getElementById("mw-dismissabl...
Read more

Israel Cuprins Etimologie | Istorie | Geografie | Politică | Demografie | Educație | Economie | Cultură | Note explicative | Note bibliografice | Bibliografie | Legături externe | Meniu de navigaresite web oficialfacebooktweeterGoogle+Instagramcanal YouTubeInstagramtextmodificaremodificarewww.technion.ac.ilnew.huji.ac.ilwww.weizmann.ac.ilwww1.biu.ac.ilenglish.tau.ac.ilwww.haifa.ac.ilin.bgu.ac.ilwww.openu.ac.ilwww.ariel.ac.ilCIA FactbookHarta Israelului"Negotiating Jerusalem," Palestine–Israel JournalThe Schizoid Nature of Modern Hebrew: A Slavic Language in Search of a Semitic Past„Arabic in Israel: an official language and a cultural bridge”„Latest Population Statistics for Israel”„Israel Population”„Tables”„Report for Selected Countries and Subjects”Human Development Report 2016: Human Development for Everyone„Distribution of family income - Gini index”The World FactbookJerusalem Law„Israel”„Israel”„Zionist Leaders: David Ben-Gurion 1886–1973”„The status of Jerusalem”„Analysis: Kadima's big plans”„Israel's Hard-Learned Lessons”„The Legacy of Undefined Borders, Tel Aviv Notes No. 40, 5 iunie 2002”„Israel Journal: A Land Without Borders”„Population”„Israel closes decade with population of 7.5 million”Time Series-DataBank„Selected Statistics on Jerusalem Day 2007 (Hebrew)”Golan belongs to Syria, Druze protestGlobal Survey 2006: Middle East Progress Amid Global Gains in FreedomWHO: Life expectancy in Israel among highest in the worldInternational Monetary Fund, World Economic Outlook Database, April 2011: Nominal GDP list of countries. Data for the year 2010.„Israel's accession to the OECD”Popular Opinion„On the Move”Hosea 12:5„Walking the Bible Timeline”„Palestine: History”„Return to Zion”An invention called 'the Jewish people' – Haaretz – Israel NewsoriginalJewish and Non-Jewish Population of Palestine-Israel (1517–2004)ImmigrationJewishvirtuallibrary.orgChapter One: The Heralders of Zionism„The birth of modern Israel: A scrap of paper that changed history”„League of Nations: The Mandate for Palestine, 24 iulie 1922”The Population of Palestine Prior to 1948originalBackground Paper No. 47 (ST/DPI/SER.A/47)History: Foreign DominationTwo Hundred and Seventh Plenary Meeting„Israel (Labor Zionism)”Population, by Religion and Population GroupThe Suez CrisisAdolf EichmannJustice Ministry Reply to Amnesty International Report„The Interregnum”Israel Ministry of Foreign Affairs – The Palestinian National Covenant- July 1968Research on terrorism: trends, achievements & failuresThe Routledge Atlas of the Arab–Israeli conflict: The Complete History of the Struggle and the Efforts to Resolve It"George Habash, Palestinian Terrorism Tactician, Dies at 82."„1973: Arab states attack Israeli forces”Agranat Commission„Has Israel Annexed East Jerusalem?”original„After 4 Years, Intifada Still Smolders”From the End of the Cold War to 2001originalThe Oslo Accords, 1993Israel-PLO Recognition – Exchange of Letters between PM Rabin and Chairman Arafat – Sept 9- 1993Foundation for Middle East PeaceSources of Population Growth: Total Israeli Population and Settler Population, 1991–2003original„Israel marks Rabin assassination”The Wye River Memorandumoriginal„West Bank barrier route disputed, Israeli missile kills 2”"Permanent Ceasefire to Be Based on Creation Of Buffer Zone Free of Armed Personnel Other than UN, Lebanese Forces"„Hezbollah kills 8 soldiers, kidnaps two in offensive on northern border”„Olmert confirms peace talks with Syria”„Battleground Gaza: Israeli ground forces invade the strip”„IDF begins Gaza troop withdrawal, hours after ending 3-week offensive”„THE LAND: Geography and Climate”„Area of districts, sub-districts, natural regions and lakes”„Israel - Geography”„Makhteshim Country”Israel and the Palestinian Territories„Makhtesh Ramon”„The Living Dead Sea”„Temperatures reach record high in Pakistan”„Climate Extremes In Israel”Israel in figures„Deuteronom”„JNF: 240 million trees planted since 1901”„Vegetation of Israel and Neighboring Countries”Environmental Law in Israel„Executive branch”„Israel's election process explained”„The Electoral System in Israel”„Constitution for Israel”„All 120 incoming Knesset members”„Statul ISRAEL”„The Judiciary: The Court System”„Israel's high court unique in region”„Israel and the International Criminal Court: A Legal Battlefield”„Localities and population, by population group, district, sub-district and natural region”„Israel: Districts, Major Cities, Urban Localities & Metropolitan Areas”„Israel-Egypt Relations: Background & Overview of Peace Treaty”„Solana to Haaretz: New Rules of War Needed for Age of Terror”„Israel's Announcement Regarding Settlements”„United Nations Security Council Resolution 497”„Security Council resolution 478 (1980) on the status of Jerusalem”„Arabs will ask U.N. to seek razing of Israeli wall”„Olmert: Willing to trade land for peace”„Mapping Peace between Syria and Israel”„Egypt: Israel must accept the land-for-peace formula”„Israel: Age structure from 2005 to 2015”„Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990–2013: quantifying the epidemiological transition”10.1016/S0140-6736(15)61340-X„World Health Statistics 2014”„Life expectancy for Israeli men world's 4th highest”„Family Structure and Well-Being Across Israel's Diverse Population”„Fertility among Jewish and Muslim Women in Israel, by Level of Religiosity, 1979-2009”„Israel leaders in birth rate, but poverty major challenge”„Ethnic Groups”„Israel's population: Over 8.5 million”„Israel - Ethnic groups”„Jews, by country of origin and age”„Minority Communities in Israel: Background & Overview”„Israel”„Language in Israel”„Selected Data from the 2011 Social Survey on Mastery of the Hebrew Language and Usage of Languages”„Religions”„5 facts about Israeli Druze, a unique religious and ethnic group”„Israël”Israel Country Study Guide„Haredi city in Negev – blessing or curse?”„New town Harish harbors hopes of being more than another Pleasantville”„List of localities, in alphabetical order”„Muncitorii români, doriți în Israel”„Prietenia româno-israeliană la nevoie se cunoaște”„The Higher Education System in Israel”„Middle East”„Academic Ranking of World Universities 2016”„Israel”„Israel”„Jewish Nobel Prize Winners”„All Nobel Prizes in Literature”„All Nobel Peace Prizes”„All Prizes in Economic Sciences”„All Nobel Prizes in Chemistry”„List of Fields Medallists”„Sakharov Prize”„Țara care și-a sfidat "destinul" și se bate umăr la umăr cu Silicon Valley”„Apple's R&D center in Israel grew to about 800 employees”„Tim Cook: Apple's Herzliya R&D center second-largest in world”„Lecții de economie de la Israel”„Land use”Israel Investment and Business GuideA Country Study: IsraelCentral Bureau of StatisticsFlorin Diaconu, „Kadima: Flexibilitate și pragmatism, dar nici un compromis în chestiuni vitale", în Revista Institutului Diplomatic Român, anul I, numărul I, semestrul I, 2006, pp. 71-72Florin Diaconu, „Likud: Dreapta israeliană constant opusă retrocedării teritoriilor cureite prin luptă în 1967", în Revista Institutului Diplomatic Român, anul I, numărul I, semestrul I, 2006, pp. 73-74MassadaIsraelul a crescut in 50 de ani cât alte state intr-un mileniuIsrael Government PortalIsraelIsraelIsraelmmmmmXX451232cb118646298(data)4027808-634110000 0004 0372 0767n7900328503691455-bb46-37e3-91d2-cb064a35ffcc1003570400564274ge1294033523775214929302638955X146498911146498911

Image
Mentenanță CS1: Dată și anMentenanță CS1: Utilizare explicită a lui et al.IsraelȚări în Orientul MijlociuRepubliciSionismState membre ale Organizației Națiunilor Unite ebraicăarabărepublică parlamentarăOrientul MijlociuMării MediteraneLibanulSiriaIordaniaCisiordaniaEgiptFâșia GazaIerusalimTel AvivOrganizației Națiunilor Unite14 mai1948Mandatului britanic pentru PalestinaDavid Ben-GurionOrganizației SionisteAgenției Evreiești pentru PalestinaStatului IsraelONULiga ArabăpalestinieneRăzboiul arabo-israelian din 1948Conflict arabo-israelianTransiordaniaEgiptulRăzboiului de Șase ZileCisiordaniaPeninsula SinaiFâșia GazaÎnălțimile GolanBiroului Central de Statisticădruzicerchezisamariteniarmenidemocrație reprezentativăsistem parlamentarvot universalKnessetulgaze naturaleIndicelui Dezvoltării UmaneOCDEȚara I...
Read more

Кастелфранко ди Сопра Становништво Референце Спољашње везе Мени за навигацију43°37′18″ СГШ; 11°33′32″ ИГД / 43.62156° СГШ; 11.55885° ИГД / 43.62156; 11.5588543°37′18″ СГШ; 11°33′32″ ИГД / 43.62156° СГШ; 11.55885° ИГД / 43.62156; 11.558853179688„The GeoNames geographical database”„Istituto Nazionale di Statistica”проширитиууWorldCat156923403n850174324558639-1cb14643287r(подаци)

Image
Acquaborra-CaselleAdattiAlbergoAlberoroAmbraAnatraiaAnciolinaAnghiariAntriaAppaltoArea ProduttivaArezzoArsicciAvenaBaccanelloBadia A RuotiBadia AgnanoBadia PratagliaBadia TedaldaBadia TegaBadia al PinoBadicorteBadiola IBadiola IIBagnaiaBagnolo IBagnolo IIBanzenaBarbianoBarullo-CentoiaBatelliBattifolle-Ruscello-PoggiolaBattifolloBecarinoBeglianoBellavistaBellosguardoBertineBibbianoBibbienaBiccianoBiforcoBigurroBorgaccianoBorghettoBorgo alla CollinaBorgonuovoBorroBossi-CellaioBottegaBrancialinoBucineBugianaBuianoBulcianoBuon RiposoButaleCafaggioCaianoCalbuffaCalcinaiaCallagnoloCalletaCalucacciaCamaldoliCampaccioCampiCampogialliCampoleoneCampolombardoCampoluciCamprenaCamucia-MonsiglioloCapannoleCapezziCapolonaCaposelviCappella BrocchiCappuccini di MontautoCappucciniCapraiaCaprese MichelangeloCaprileCardaCardeta di SopraCarmineCasa BiondoCasa CaroniCasa MarcoCasa MugnainiCasa Vanni - le SelveCasa al CincioCasa alla SisaCasa del ReCasa le BizzeCasacciola-BelvedereCasal GoriCasaleCasalecchio...
Read more