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Antimineralokortikoid Садржај Mehanizam dejstva Primeri Vidi još Reference Spoljašnje veze Мени за навигацијуAldosterone+Antagonists82000451уу

Антагонисти алдостеронаСтероиди


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Antimineralokortikoid




Из Википедије, слободне енциклопедије

(преусмерено са Antagonisti aldosterona)





Иди на навигацију
Иди на претрагу




Strukturne formule aldosteronskih antagonista


Antimineralokortikoid (aldosteronski antagonist) je diuretički lek koji ometa dejstvo aldosterona na mineralokortikoidnim receptorima. Ova grupa lekova se često koristi kao pomoćna terapija, u kombinaciji sa drugim lekovima, za tretman hroničnog zatajenja srca. Spironolakton, prvi član ove klase, se takođe koristi za lečenje hiperaldosteronizma (uključujući Konov sindrom) i ženskog hirsutizma.




Садржај





  • 1 Mehanizam dejstva


  • 2 Primeri


  • 3 Vidi još


  • 4 Reference


  • 5 Spoljašnje veze




Mehanizam dejstva


Aldosteronski antagonisti imaju afinitet za mineralokortikoidni receptor. Antagonizam tog receptora inhibira resorpciju natrijuma u prikupljajućim kanalima nefrona u bubrezima. Time se ometa razmena natrijuma i kalijuma, redukuje urinarno izlučivanje kalijuma i u manjoj meri povišava izlučivanje vode (diureza).[1]



Primeri


Deo članova ove klase koji su u kliničkoj upotrebi je:


  • Spironolakton


  • Eplerenon - ima veću specifičnost od spironolaktona


  • Kanrenon (kanrenoat kalijum)


  • Prorenon (prorenoat kalijum)


  • Meksrenon (meksrenoat kalijum)


Vidi još


  • Mineralokortikoid

  • Kortikosteroid

  • Antiglukokortikoid


Reference




  1. ^ Rossi S, editor. Australian Medicines Handbook 2006. Adelaide: Australian Medicines Handbook; 2006.




Spoljašnje veze



  • MeSH Aldosterone+Antagonists


  • MeSH lista agensa 82000451










Преузето из „https://sr.wikipedia.org/w/index.php?title=Antimineralokortikoid&oldid=8520657”










Мени за навигацију


























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