Fluocinolon acetonid Садржај Osobine Reference Literatura Spoljašnje veze Мени за навигацијуacetonide.html Monografija67-73-2WHOBA086215DB005915980CHEMBL989179235371772251311006254„DrugBank 3.0: a comprehensive resource for omics research on drugs”30137092105968210.1093/nar/gkq1126„DrugBank: a knowledgebase for drugs, drug actions and drug targets”22388891804841210.1093/nar/gkm958„Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”10.1021/jp980230o„Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”1174957310.1021/ci000392t„Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”1102028610.1021/jm000942eGoodman & Gilman's The Pharmacological Basis of Therapeutics10.1036/0071422803Foye's Principles of Medicinal ChemistryFluocinolon acetonidVikimedijinoj ostaviFluocinolone acetonideу
Антиинфламаторни агенсиАнтипруритициГлукокортикоидиАлкохолиСтероидиКетониОрганофлуоридиКетали
organsko jedinjenjeatomaugljenikamolekulsku masuDaMENDanatphysdevphormcellnocodcongtumrsysieponproclekA10H1H2H3H5
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Fluocinolon acetonid
Иди на навигацију
Иди на претрагу
 | |
| Klinički podaci | |
|---|---|
| Prodajno ime | Coriphate, Derma-smoothe/fs, Dermalar, Flucinar |
| Drugs.com | acetonide.html Monografija |
| Način primene | topikalno, intraokularno |
Farmakokinetički podaci | |
| Poluvreme eliminacije | 1,3-1,7 h |
| Izlučivanje | Renalno |
| Identifikatori | |
| CAS broj | 67-73-2  Y |
| ATC kod | C05AA10 (WHO), S02BA08 |
| PubChem | CID 6215 |
| DrugBank | DB00591 Y |
| ChemSpider | 5980 Y |
| ChEMBL | CHEMBL989 Y |
| Hemijski podaci | |
| Formula | C24H30F2O6 |
| Molarna masa | 452,488 |
SMILES
| |
InChI
| |
| Fizički podaci | |
| Tačka topljenja | 265—266 °C (509—511 °F) |
Fluocinolon acetonid je organsko jedinjenje, koje sadrži 24 atoma ugljenika i ima molekulsku masu od 452,488 Da.[1][2][3][4][5]
Садржај
1 Osobine
2 Reference
3 Literatura
4 Spoljašnje veze
Osobine
| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 6 |
| Broj donora vodonika | 2 |
| Broj rotacionih veza | 2 |
Particioni koeficijent[6] (ALogP) | 1,0 |
Rastvorljivost[7] (logS, log(mol/L)) | -4,3 |
Polarna površina[8] (PSA, Å2) | 93,1 |
Reference
^ Goldstein DA, Godfrey DG, Hall A, Callanan DG, Jaffe GJ, Pearson PA, Usner DW, Comstock TL: Intraocular pressure in patients with uveitis treated with fluocinolone acetonide implants. Arch Ophthalmol. 2007 Nov;125(11):1478-85. Epub 2007 Oct 8. PMID 17923537
^ Brumm MV, Nguyen QD: Fluocinolone acetonide intravitreal sustained release device--a new addition to the armamentarium of uveitic management. Int J Nanomedicine. 2007;2(1):55-64. PMID 17722513
^ Jaffe GJ, Yang CH, Guo H, Denny JP, Lima C, Ashton P: Safety and pharmacokinetics of an intraocular fluocinolone acetonide sustained delivery device. Invest Ophthalmol Vis Sci. 2000 Oct;41(11):3569-75. PMID 11006254
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126.
^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889. PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura
.mw-parser-output .refbeginfont-size:90%;margin-bottom:0.5em.mw-parser-output .refbegin-hanging-indents>ullist-style-type:none;margin-left:0.mw-parser-output .refbegin-hanging-indents>ul>li,.mw-parser-output .refbegin-hanging-indents>dl>ddmargin-left:0;padding-left:3.2em;text-indent:-3.2em;list-style:none.mw-parser-output .refbegin-100font-size:100%
Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
 | Fluocinolon acetonid na Vikimedijinoj ostavi. |
- Fluocinolone acetonide
 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
Категорије:
- Антиинфламаторни агенси
- Антипруритици
- Глукокортикоиди
- Алкохоли
- Стероиди
- Кетони
- Органофлуориди
- Кетали
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