Budesonid Садржај Osobine Reference Literatura Spoljašnje veze Мени за навигацијуMonografija51333-22-3WHOBA0240000DB0122236566CHEBI:3207CHEMBL1370„Budesonide”„Budesonide eent”2508922810.1007/s13665-014-0084-2„Rectal budesonide and mesalamine formulations in active ulcerative proctosigmoiditis: efficacy, tolerance, and treatment approach.”48768452727430110.2147/CEG.S802372241093510.1002/lary.232592179028410.1586/eci.11.342658460210.1053/j.gastro.2015.11.006„DrugBank 3.0: a comprehensive resource for omics research on drugs”30137092105968210.1093/nar/gkq1126„DrugBank: a knowledgebase for drugs, drug actions and drug targets”22388891804841210.1093/nar/gkm958„Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”10.1021/jp980230o„Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”1174957310.1021/ci000392t„Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”1102028610.1021/jm000942eGoodman & Gilman's The Pharmacological Basis of Therapeutics10.1036/0071422803Foye's Principles of Medicinal ChemistryBudesonidVikimedijinoj ostaviBudesonideу
Антиинфламаторни агенсиБронходилататориКортикостероидиГлукокортикоидиАлкохолиСтероидиКетониКетали
kortikosteroidnognazalni sprejastmehronične opstruktivne bolesti plućaalergijski rinitisnazalne polipeupalnih bolesti crevaKronovu bolestulcerozni kolitismikroskopski kolitisorgansko jedinjenjeatomaugljenikamolekulsku masuDaMENDanatphysdevphormcellnocodcongtumrsysieponproclekA10H1H2H3H5
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Budesonid
(преусмерено са Budezonid)
Иди на навигацију
Иди на претрагу
 | |
 | |
| Klinički podaci | |
|---|---|
| Prodajno ime | Bidien, Budeson, Budicort, Cortivent |
| Drugs.com | Monografija |
| Način primene | Respiratorno (inhalacija), oralno |
Farmakokinetički podaci | |
| Poluvreme eliminacije | 2,0 - 3,6 h |
| Izlučivanje | Renalno |
| Identifikatori | |
| CAS broj | 51333-22-3  Y |
| ATC kod | A07EA06 (WHO), R03BA02 |
| PubChem | CID 40000 |
| DrugBank | DB01222 Y |
| ChemSpider | 36566 Y |
| ChEBI | CHEBI:3207 Y |
| ChEMBL | CHEMBL1370 Y |
| Hemijski podaci | |
| Formula | C25H34O6 |
| Molarna masa | 430,54 g·mol−1 |
SMILES
| |
InChI
| |
Budesonid (BUD), u prodaji pod imenom Pulmicort između ostalih, je lek kortikosteroidnog tipa.[1] On je dostupan u inhalacionom obliku, kao pilula, nazalni sprej, i u rektalnoj formi.[1][2] Inhalaciona forma se koristi u dugotrajnom tretmanu astme i hronične opstruktivne bolesti pluća (COPD).[1][3][4] Nazalni sprej se koristi za alergijski rinitis i nazalne polipe.[2][5] Pilule sa odloženim oslobađanjem i rektalne forme se mogu koristiti za tretman upalnih bolesti creva uključujući Kronovu bolest, ulcerozni kolitis i mikroskopski kolitis.[6][7]
Садржај
1 Osobine
2 Reference
3 Literatura
4 Spoljašnje veze
Osobine
Budesonid je organsko jedinjenje, koje sadrži 25 atoma ugljenika i ima molekulsku masu od 430,534 Da.[8][9]
| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 6 |
| Broj donora vodonika | 2 |
| Broj rotacionih veza | 4 |
Particioni koeficijent[10] (ALogP) | 2,2 |
Rastvorljivost[11] (logS, log(mol/L)) | -4,2 |
Polarna površina[12] (PSA, Å2) | 93,1 |
Reference
↑ 1,01,11,2 „Budesonide”. The American Society of Health-System Pharmacists. Приступљено 2. 12. 2015.
↑ 2,02,1 „Budesonide eent”. The American Society of Health-System Pharmacists. Приступљено 2. 12. 2015.
^ De Coster, DA; Jones, M (2014). „Tailoring of corticosteroids in COPD management.”. Current respiratory care reports. 3: 121—132. PMID 25089228. doi:10.1007/s13665-014-0084-2.
^ Christophi, GP; Rengarajan, A; Ciorba, MA (2016). „Rectal budesonide and mesalamine formulations in active ulcerative proctosigmoiditis: efficacy, tolerance, and treatment approach.”. Clinical and experimental gastroenterology. 9: 125—30. PMC 4876845
. PMID 27274301. doi:10.2147/CEG.S80237.
^ Rudmik, L; Schlosser, RJ; Smith, TL; Soler, ZM (2012). „Impact of topical nasal steroid therapy on symptoms of nasal polyposis: a meta-analysis.”. The Laryngoscope. 122 (7): 1431—7. PMID 22410935. doi:10.1002/lary.23259.
^ Silverman J, Otley A (2011). „Budesonide in the treatment of inflammatory bowel disease.”. Expert Rev Clin Immunol. 7 (4): 419—28. PMID 21790284. doi:10.1586/eci.11.34.
^ Pardi DS, Tremaine WJ, Carrasco-Labra A (2016). „American Gastroenterological Association Institute Technical Review on the Medical Management of Microscopic Colitis”. Gastroenterology. 150 (1): 247—274.e11. PMID 26584602. doi:10.1053/j.gastro.2015.11.006.
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709. PMID 21059682. doi:10.1093/nar/gkq1126.
^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889. PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura
.mw-parser-output .refbeginfont-size:90%;margin-bottom:0.5em.mw-parser-output .refbegin-hanging-indents>ullist-style-type:none;margin-left:0.mw-parser-output .refbegin-hanging-indents>ul>li,.mw-parser-output .refbegin-hanging-indents>dl>ddmargin-left:0;padding-left:3.2em;text-indent:-3.2em;list-style:none.mw-parser-output .refbegin-100font-size:100%
Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
 | Budesonid na Vikimedijinoj ostavi. |
- Budesonide
 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
Категорије:
- Антиинфламаторни агенси
- Бронходилататори
- Кортикостероиди
- Глукокортикоиди
- Алкохоли
- Стероиди
- Кетони
- Кетали
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