Pregnan Pregnani Reference Spoljašnje veze Мени за навигацију24909-91-9Interactive imagePregnane6857422„PubChem as a public resource for drug discovery.”2097051910.1016/j.drudis.2010.10.003уреди10.1016/S1574-1400(08)00012-110.1021/jo960108q10.1530/acta.0.021024510.1016/0022-4731(81)90361-7PubChemDiagram na qmul.ac.ukDefinicija pregnanaProgesteron hemijaProgesteron rekord u Evropskoj Bioinformatičkoj bazi podatakHemijska knjigaу
ПрегнаниНеуростероидиПрогестерони
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Pregnan
(преусмерено са Pregnadientriol)
Иди на навигацију
Иди на претрагу
 | |
| Nazivi | |
|---|---|
IUPAC naziv (8S,9S,10S,13R,14S,17S)-17-ethyl-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene | |
| Identifikacija | |
CAS broj |
|
3D model (Jmol) |
|
MeSH | Pregnane |
PubChem[1][2]CID |
|
SMILES
| |
| Svojstva | |
Hemijska formula | C21H36 |
Molarna masa | 288.511 g/mol |
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa). | |
Reference infokutije | |
Pregnan je, indirektno, roditelj progesterona. To je ugljeno hidratna osnova dve serije steroida zasnovane na 5α-pregnanu (originalno alopregnan) i 5β-pregnan (17β-etiletiokolane).
5β-Pregnan je roditelj progesterona, pregnan alkohola, ketona[3], i nekoliko adrenokortikoidni hormona. On se nalazi uglavnom u urinu kao metabolički proizvod jedinjenja 5β-pregnana.[4][5]
Pregnani
Steroid nomenklatura: Pregnani imaju ugljenike 1 do 21.
Pregnani su steroidni derivati sa ugljenicima prisutnim na pozicijama 1 do 21.
Većina biološki signifikantnih pregnan derivata pripada jednoj od dve grupe: pregneni i pregnadieni[6]. Postoji i treća manja klasa pregnatrieni. Pregneni sadrže dvostruku vezu, na primer: kortizon, hidrokortizon, i progesteron. Pregnadieni imaju dve dvostruke veze, na primer: ciproteron, danazol, i fluocinonid.
Reference
^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ Nicoletti D, Ghini AA, Burton G (1996). „Oxidative Cyclization of Iodo Ketones. Synthesis of 6-Oxa-5α-pregnane-3,20-dione”. J Org Chem. 61 (19): 6673—6677. doi:10.1021/jo960108q.
^ Davis ME, Plotz EJ (1956). „The excretion of neutral steroids in the urine of normal non-pregnant and pregnant women”. Acta Endocrinologica. 21 (3): 245—258. doi:10.1530/acta.0.0210245.
^ Beguea R, Morinierea M, Nivoisa C, Sandre D, Padieu P (1981). „Identification of 5β-pregnane-3α,6α,20α-triol in urine of normal newborn infant”. Journal of Steroid Biochemistry. 14 (5): 489—491. doi:10.1016/0022-4731(81)90361-7.
^ Beyler R, Hoffman F, Sarett L (1959). „Synthesis of 1,4-Pregnadiene-17α,20α,21-triol-3,11-dione”. J Org Chem. 29 (9): 1386—1387.
Spoljašnje veze
- PubChem
- Diagram na qmul.ac.uk
- Definicija pregnana
- Progesteron hemija
- Progesteron rekord u Evropskoj Bioinformatičkoj bazi podatak
- Hemijska knjiga
Категорије:
- Прегнани
- Неуростероиди
- Прогестерони
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