Ulobetasol Садржај Osobine Reference Literatura Spoljašnje veze Мени за навигацијуMonografija98651-66-2WHO531116744706919P6159HM7TD08660CHEMBL1201360„Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”10.1021/jp980230o„Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”1174957310.1021/ci000392t„Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”1102028610.1021/jm000942eGoodman & Gilman's The Pharmacological Basis of Therapeutics10.1036/0071422803Foye's Principles of Medicinal ChemistryUlobetasolVikimedijinoj ostaviUlobetasolу
АлкохолиСтероидиКетониОрганофлуоридиОрганохлориди
INNUSANkortikosteroidpsorijazeorgansko jedinjenjeatomaugljenikamolekulsku masuDaMENDanatphysdevphormcellnocodcongtumrsysieponproclekA10H1H2H3H5
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Ulobetasol
(преусмерено са Ulobetazol)
Иди на навигацију
Иди на претрагу
 | |
| Klinički podaci | |
|---|---|
| Drugs.com | Monografija |
| Identifikatori | |
| CAS broj | 98651-66-2  Y |
| ATC kod | D07AC21 (WHO) |
| PubChem | CID 5311167 |
| ChemSpider | 4470691 Y |
| UNII | 9P6159HM7T Y |
| KEGG | D08660 Y |
| ChEMBL | CHEMBL1201360 Y |
| Sinonimi | (6S,8S,9S,10S,11S,13S,14S,16S,17R)-17-(2-Chloroacetyl)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one |
| Hemijski podaci | |
| Formula | C22H27ClF2O4 |
| Molarna masa | 428,897 |
SMILES
| |
InChI
| |
Ulobetasol (INN) ili halobetasol (USAN) je kortikosteroid koji se koristi za tretiranje psorijaze. On je kortikosterod grupe I po SAD klasifikaciji, najpotentnijoj klasi takvih lekova. Halobetasol propionat se obično priprema kao 0,05% topikalni krem.
Садржај
1 Osobine
2 Reference
3 Literatura
4 Spoljašnje veze
Osobine
Ulobetasol je organsko jedinjenje, koje sadrži 22 atoma ugljenika i ima molekulsku masu od 428,897 Da.
| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 4 |
| Broj donora vodonika | 2 |
| Broj rotacionih veza | 2 |
Particioni koeficijent[1] (ALogP) | 2,8 |
Rastvorljivost[2] (logS, log(mol/L)) | -5,3 |
Polarna površina[3] (PSA, Å2) | 74,6 |
Reference
^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura
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Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
 | Ulobetasol na Vikimedijinoj ostavi. |
- Ulobetasol
 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
Категорије:
- Алкохоли
- Стероиди
- Кетони
- Органофлуориди
- Органохлориди
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