Skip to main content

CP-94,253 Reference Spoljašnje veze Мени за навигацију131084-35-0402967710.1002/ddr.4302603051729149010.1016/j.ejphar.2006.12.01219211971у

Агонисти серотонинског рецептораФенолни етриПиридини


agonistserotoninskog5-HT1Breceptorakokaina










(function()var node=document.getElementById("mw-dismissablenotice-anonplace");if(node)node.outerHTML="u003Cdiv class="mw-dismissable-notice"u003Eu003Cdiv class="mw-dismissable-notice-close"u003E[u003Ca tabindex="0" role="button"u003Eсакријu003C/au003E]u003C/divu003Eu003Cdiv class="mw-dismissable-notice-body"u003Eu003Cdiv id="localNotice" lang="sr" dir="ltr"u003Eu003Cdiv style="position:relative; overflow:hidden; background-color:#5E9DC8; text-align:center; color:white; font-size:1.25em; font-weight:bold; line-height:1.5em; margin-top: 5px;"u003Eu003Cuu003Eu003Ca href="/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%A2%D0%B0%D0%BA%D0%BC%D0%B8%D1%87%D0%B5%D1%9A%D0%B5_%D1%83_%D0%BF%D0%B8%D1%81%D0%B0%D1%9A%D1%83_%D1%87%D0%BB%D0%B0%D0%BD%D0%B0%D0%BA%D0%B0/%D0%A6%D0%95%D0%95_%D0%BF%D1%80%D0%BE%D0%BB%D0%B5%D1%9B%D0%B5_2019" title="Википедија:Такмичење у писању чланака/ЦЕЕ пролеће 2019"u003Eu003Cspan style="color:white"u003EТакмичите се у писању чланака о Средњој и Источној Европи од 21. марта до 31. маја!u003C/spanu003Eu003C/au003Eu003C/uu003Eu003C/divu003Enu003Cdiv style="position:relative; overflow:hidden; background-color:#5E9DC8; text-align:center; color:white; font-size:1.25em; font-weight:bold; line-height:1.5em; margin-top: 5px;"u003EУ току је гласање о u003Ca href="/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%93%D0%BB%D0%B0%D1%81%D0%B0%D1%9A%D0%B5/%D0%9E%D0%BC%D0%BE%D0%B3%D1%83%D1%9B%D0%B0%D0%B2%D0%B0%D1%9A%D0%B5_%D0%B4%D0%B5%D0%BB%D0%B8%D0%BC%D0%B8%D1%87%D0%BD%D0%B8%D1%85_%D0%B1%D0%BB%D0%BE%D0%BA%D0%B0%D0%B4%D0%B0" title="Википедија:Гласање/Омогућавање делимичних блокада"u003Eu003Cspan style="color:white"u003Eu003Cuu003Eомогућавању делимичних блокадаu003C/uu003Eu003C/spanu003Eu003C/au003E и u003Ca href="/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%93%D0%BB%D0%B0%D1%81%D0%B0%D1%9A%D0%B5/%D0%9E%D0%BC%D0%BE%D0%B3%D1%83%D1%9B%D0%B0%D0%B2%D0%B0%D1%9A%D0%B5_%D0%92%D0%B8%D0%B7%D1%83%D0%B5%D0%BB%D0%BD%D0%BE%D0%B3_%D1%83%D1%80%D0%B5%D1%92%D0%B8%D0%B2%D0%B0%D1%87%D0%B0_%D1%83_%D0%BF%D1%80%D0%BE%D1%81%D1%82%D0%BE%D1%80%D1%83_%D0%BD%D0%B0%D1%86%D1%80%D1%82%D0%B0" title="Википедија:Гласање/Омогућавање Визуелног уређивача у простору нацрта"u003Eu003Cspan style="color:white"u003Eu003Cuu003EВизуелног уређивача у простору нацртаu003C/uu003Eu003C/spanu003Eu003C/au003E!u003C/divu003Enu003Cdiv style="position:relative; overflow:hidden; background-color:#5E9DC8; text-align:center; color:white; font-size:1.25em; font-weight:bold; line-height:1.5em; margin-top: 5px;"u003Eu003Cuu003Eu003Ca href="/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%93%D0%BB%D0%B0%D1%81%D0%B0%D1%9A%D0%B5/%D0%9F%D1%80%D0%B5%D0%B4%D0%BB%D0%BE%D0%B3/%D0%94%D0%BE%D0%BF%D1%83%D0%BD%D0%B0_%D0%BF%D1%80%D0%B0%D0%B2%D0%B8%D0%BB%D0%B0_%D0%BE_%D0%B8%D0%B7%D0%B0%D0%B1%D1%80%D0%B0%D0%BD%D0%B8%D0%BC_%D1%81%D0%BB%D0%B8%D0%BA%D0%B0%D0%BC%D0%B0" title="Википедија:Гласање/Предлог/Допуна правила о изабраним сликама"u003Eu003Cspan style="color:white"u003EУ току је расправа о допуни правила везаних за изабране слике!u003C/spanu003Eu003C/au003Eu003C/uu003Eu003C/divu003Eu003C/divu003Eu003C/divu003Eu003C/divu003E";());




CP-94,253




Из Википедије, слободне енциклопедије






Иди на навигацију
Иди на претрагу













CP-94,253
CP-94253 structure.png

IUPAC ime
3-(1,2,5,6-tetrahidro-4-piridil)-5-propoksipirolo[3,2-b]piridin
Identifikatori
CAS broj
131084-35-0 ДаY
ATC kodnone
PubChemCID 4029677
Hemijski podaci
Formula
C15H19N3O
Molarna masa257,330 g/mol



CP-94,253 je lek koji deluje kao potentan i selektivan agonist serotoninskog 5-HT1B receptora, sa aproksimativno 25x i 40x selektivnošću u odnosu na blisko srodne 5-HT1D i 5-HT1A receptore.[1] On pokazuje opseg biheviouralnih efekata u životinjskim studijama, uključujući promovisanje budnosti putem povećanja dopaminskog otpuštanja u mozgu,[2][3] redukovanje unosa hrane i povećanja sitosti,[4][5][6] pojačanja dejstva kokaina,[7][8][9][10] kao i moguće antidepresivno dejstvo.[11]



Reference




  1. ^ Koe KB, Nielsen JA, Macor JE, Heym J. Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253. Drug Development Research. 1992;26(3):241-250. doi:10.1002/ddr.430260305


  2. ^ Monti JM, Monti D, Jantos H, Ponzoni A. Effects of selective activation of the 5-HT1B receptor with CP-94,253 on sleep and wakefulness in the rat. Neuropharmacology. 1995 Dec;34(12):1647-51. PMID 8788962


  3. ^ Iyer RN, Bradberry CW. Serotonin-mediated increase in prefrontal cortex dopamine release: pharmacological characterization. Journal of Pharmacology and Experimental Therapeutics. 1996 Apr;277(1):40-7. PMID 8613947


  4. ^ Halford JC, Blundell JE. The 5-HT1B receptor agonist CP-94,253 reduces food intake and preserves the behavioural satiety sequence. Physiology and Behaviour. 1996 Sep;60(3):933-9. PMID 8873272


  5. ^ Lee MD, Simansky KJ. CP-94,253: a selective serotonin1B (5-HT1B) agonist that promotes satiety. Psychopharmacology (Berlin). 1997 Jun;131(3):264-70. PMID 9203237


  6. ^ Lee MD, Kennett GA, Dourish CT, Clifton PG. 5-HT1B receptors modulate components of satiety in the rat: behavioural and pharmacological analyses of the selective serotonin1B agonist CP-94,253. Psychopharmacology (Berlin). 2002 Oct;164(1):49-60. PMID 12373419


  7. ^ Parsons LH, Weiss F, Koob GF. Serotonin1B receptor stimulation enhances cocaine reinforcement. Journal of Neuroscience. 1998 Dec 1;18(23):10078-89. PMID 9822762


  8. ^ Przegalinski E, Filip M, Papla I, Siwanowicz J. Effect of serotonin (5-HT)1B receptor ligands on cocaine sensitization in rats. Behavioural Pharmacology. 2001 Apr;12(2):109-16. PMID 11396515


  9. ^ Przegaliński E, Gołda A, Frankowska M, Zaniewska M, Filip M (2007). „Effects of serotonin 5-HT1B receptor ligands on the cocaine- and food-maintained self-administration in rats”. European Journal of Pharmacology. 559 (2-3): 165—72. PMID 17291490. doi:10.1016/j.ejphar.2006.12.012. 


  10. ^ Przegaliński E, Gołda A, Filip M (2008). „Effects of serotonin (5-HT)(1B) receptor ligands on cocaine-seeking behavior in rats”. Pharmacological Reports : PR. 60 (6): 798—810. PMID 19211971. 


  11. ^ Tatarczyńska E, Antkiewicz-Michaluk L, Kłodzińska A, Stachowicz K, Chojnacka-Wójcik E. Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: a possible mechanism of action. European Journal of Pharmacology. 2005 May 23;516(1):46-50. PMID 15913599



Spoljašnje veze











Преузето из „https://sr.wikipedia.org/w/index.php?title=CP-94,253&oldid=12335541”










Мени за навигацију


























(window.RLQ=window.RLQ||[]).push(function()mw.config.set("wgPageParseReport":"limitreport":"cputime":"0.580","walltime":"0.685","ppvisitednodes":"value":3866,"limit":1000000,"ppgeneratednodes":"value":0,"limit":1500000,"postexpandincludesize":"value":293866,"limit":2097152,"templateargumentsize":"value":37978,"limit":2097152,"expansiondepth":"value":17,"limit":40,"expensivefunctioncount":"value":0,"limit":500,"unstrip-depth":"value":0,"limit":20,"unstrip-size":"value":7859,"limit":5000000,"entityaccesscount":"value":0,"limit":400,"timingprofile":["100.00% 435.666 1 -total"," 53.38% 232.567 1 Шаблон:Drugbox-lat"," 44.91% 195.660 2 Шаблон:Infobox"," 20.16% 87.824 1 Шаблон:Reflist"," 17.89% 77.942 1 Шаблон:Serotonergici-lat"," 16.99% 74.040 1 Шаблон:Navbox_with_collapsible_sections"," 13.78% 60.018 2 Шаблон:Cite_journal"," 6.04% 26.296 1 Шаблон:Infobox_drug-lat/chemical_formula"," 5.57% 24.259 8 Шаблон:Navbox_subgroup"," 3.94% 17.176 2 Шаблон:Keypress"],"scribunto":"limitreport-timeusage":"value":"0.137","limit":"10.000","limitreport-memusage":"value":4285890,"limit":52428800,"cachereport":"origin":"mw1309","timestamp":"20190428013017","ttl":2592000,"transientcontent":false););"@context":"https://schema.org","@type":"Article","name":"CP-94,253","url":"https://sr.wikipedia.org/wiki/CP-94,253","sameAs":"http://www.wikidata.org/entity/Q5013587","mainEntity":"http://www.wikidata.org/entity/Q5013587","author":"@type":"Organization","name":"u0421u0430u0440u0430u0434u043du0438u0446u0438 u043fu0440u043eu0458u0435u043au0430u0442u0430 u0412u0438u043au0438u043cu0435u0434u0438u0458u0435","publisher":"@type":"Organization","name":"Wikimedia Foundation, Inc.","logo":"@type":"ImageObject","url":"https://www.wikimedia.org/static/images/wmf-hor-googpub.png","datePublished":"2012-10-27T15:18:53Z","dateModified":"2017-01-05T06:49:01Z","image":"https://upload.wikimedia.org/wikipedia/commons/f/fd/CP-94253_structure.png"(window.RLQ=window.RLQ||[]).push(function()mw.config.set("wgBackendResponseTime":190,"wgHostname":"mw1238"););
-

Popular posts from this blog

19. јануар Садржај Догађаји Рођења Смрти Празници и дани сећања Види још Референце Мени за навигацијуу

Image
1.2.3.4.5.6.7.8.9.10.11.12.13.14.15.16.17.18.19.20.21.22.23.24.25.26.27.28.29.30.31.1.2.3.4.5.6.7.8.9.10.11.12.13.14.15.16.17.18.19.20.21.22.23.24.25.26.27.28.29.30.31.1.2.3.4.5.6.7.8.9.10.11.12.13.14.15.16.17.18.19.20.21.22.23.24.25.26.27.28.29.30.31.1.2.3.4.5.6.7.8.9.10.11.12.13.14.15.16.17.18.19.20.21.22.23.24.25.26.27.28.29.30.31.1.2.3.4.5.6.7.8.9.10.11.12.13.14.15.16.17.18.19.20.21.22.23.24.25.26.27.28.29.30.1.2.3.4.5.6.7.8.9.10.11.12.13.14.15.16.17.18.19.20.21.22.23.24.25.26.27.28.29.30. ЈануарДани деветнаестиГрегоријанском календарупреступним годинама (function()var node=document.getElementById("mw-dismissabl...
Read more

Israel Cuprins Etimologie | Istorie | Geografie | Politică | Demografie | Educație | Economie | Cultură | Note explicative | Note bibliografice | Bibliografie | Legături externe | Meniu de navigaresite web oficialfacebooktweeterGoogle+Instagramcanal YouTubeInstagramtextmodificaremodificarewww.technion.ac.ilnew.huji.ac.ilwww.weizmann.ac.ilwww1.biu.ac.ilenglish.tau.ac.ilwww.haifa.ac.ilin.bgu.ac.ilwww.openu.ac.ilwww.ariel.ac.ilCIA FactbookHarta Israelului"Negotiating Jerusalem," Palestine–Israel JournalThe Schizoid Nature of Modern Hebrew: A Slavic Language in Search of a Semitic Past„Arabic in Israel: an official language and a cultural bridge”„Latest Population Statistics for Israel”„Israel Population”„Tables”„Report for Selected Countries and Subjects”Human Development Report 2016: Human Development for Everyone„Distribution of family income - Gini index”The World FactbookJerusalem Law„Israel”„Israel”„Zionist Leaders: David Ben-Gurion 1886–1973”„The status of Jerusalem”„Analysis: Kadima's big plans”„Israel's Hard-Learned Lessons”„The Legacy of Undefined Borders, Tel Aviv Notes No. 40, 5 iunie 2002”„Israel Journal: A Land Without Borders”„Population”„Israel closes decade with population of 7.5 million”Time Series-DataBank„Selected Statistics on Jerusalem Day 2007 (Hebrew)”Golan belongs to Syria, Druze protestGlobal Survey 2006: Middle East Progress Amid Global Gains in FreedomWHO: Life expectancy in Israel among highest in the worldInternational Monetary Fund, World Economic Outlook Database, April 2011: Nominal GDP list of countries. Data for the year 2010.„Israel's accession to the OECD”Popular Opinion„On the Move”Hosea 12:5„Walking the Bible Timeline”„Palestine: History”„Return to Zion”An invention called 'the Jewish people' – Haaretz – Israel NewsoriginalJewish and Non-Jewish Population of Palestine-Israel (1517–2004)ImmigrationJewishvirtuallibrary.orgChapter One: The Heralders of Zionism„The birth of modern Israel: A scrap of paper that changed history”„League of Nations: The Mandate for Palestine, 24 iulie 1922”The Population of Palestine Prior to 1948originalBackground Paper No. 47 (ST/DPI/SER.A/47)History: Foreign DominationTwo Hundred and Seventh Plenary Meeting„Israel (Labor Zionism)”Population, by Religion and Population GroupThe Suez CrisisAdolf EichmannJustice Ministry Reply to Amnesty International Report„The Interregnum”Israel Ministry of Foreign Affairs – The Palestinian National Covenant- July 1968Research on terrorism: trends, achievements & failuresThe Routledge Atlas of the Arab–Israeli conflict: The Complete History of the Struggle and the Efforts to Resolve It"George Habash, Palestinian Terrorism Tactician, Dies at 82."„1973: Arab states attack Israeli forces”Agranat Commission„Has Israel Annexed East Jerusalem?”original„After 4 Years, Intifada Still Smolders”From the End of the Cold War to 2001originalThe Oslo Accords, 1993Israel-PLO Recognition – Exchange of Letters between PM Rabin and Chairman Arafat – Sept 9- 1993Foundation for Middle East PeaceSources of Population Growth: Total Israeli Population and Settler Population, 1991–2003original„Israel marks Rabin assassination”The Wye River Memorandumoriginal„West Bank barrier route disputed, Israeli missile kills 2”"Permanent Ceasefire to Be Based on Creation Of Buffer Zone Free of Armed Personnel Other than UN, Lebanese Forces"„Hezbollah kills 8 soldiers, kidnaps two in offensive on northern border”„Olmert confirms peace talks with Syria”„Battleground Gaza: Israeli ground forces invade the strip”„IDF begins Gaza troop withdrawal, hours after ending 3-week offensive”„THE LAND: Geography and Climate”„Area of districts, sub-districts, natural regions and lakes”„Israel - Geography”„Makhteshim Country”Israel and the Palestinian Territories„Makhtesh Ramon”„The Living Dead Sea”„Temperatures reach record high in Pakistan”„Climate Extremes In Israel”Israel in figures„Deuteronom”„JNF: 240 million trees planted since 1901”„Vegetation of Israel and Neighboring Countries”Environmental Law in Israel„Executive branch”„Israel's election process explained”„The Electoral System in Israel”„Constitution for Israel”„All 120 incoming Knesset members”„Statul ISRAEL”„The Judiciary: The Court System”„Israel's high court unique in region”„Israel and the International Criminal Court: A Legal Battlefield”„Localities and population, by population group, district, sub-district and natural region”„Israel: Districts, Major Cities, Urban Localities & Metropolitan Areas”„Israel-Egypt Relations: Background & Overview of Peace Treaty”„Solana to Haaretz: New Rules of War Needed for Age of Terror”„Israel's Announcement Regarding Settlements”„United Nations Security Council Resolution 497”„Security Council resolution 478 (1980) on the status of Jerusalem”„Arabs will ask U.N. to seek razing of Israeli wall”„Olmert: Willing to trade land for peace”„Mapping Peace between Syria and Israel”„Egypt: Israel must accept the land-for-peace formula”„Israel: Age structure from 2005 to 2015”„Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990–2013: quantifying the epidemiological transition”10.1016/S0140-6736(15)61340-X„World Health Statistics 2014”„Life expectancy for Israeli men world's 4th highest”„Family Structure and Well-Being Across Israel's Diverse Population”„Fertility among Jewish and Muslim Women in Israel, by Level of Religiosity, 1979-2009”„Israel leaders in birth rate, but poverty major challenge”„Ethnic Groups”„Israel's population: Over 8.5 million”„Israel - Ethnic groups”„Jews, by country of origin and age”„Minority Communities in Israel: Background & Overview”„Israel”„Language in Israel”„Selected Data from the 2011 Social Survey on Mastery of the Hebrew Language and Usage of Languages”„Religions”„5 facts about Israeli Druze, a unique religious and ethnic group”„Israël”Israel Country Study Guide„Haredi city in Negev – blessing or curse?”„New town Harish harbors hopes of being more than another Pleasantville”„List of localities, in alphabetical order”„Muncitorii români, doriți în Israel”„Prietenia româno-israeliană la nevoie se cunoaște”„The Higher Education System in Israel”„Middle East”„Academic Ranking of World Universities 2016”„Israel”„Israel”„Jewish Nobel Prize Winners”„All Nobel Prizes in Literature”„All Nobel Peace Prizes”„All Prizes in Economic Sciences”„All Nobel Prizes in Chemistry”„List of Fields Medallists”„Sakharov Prize”„Țara care și-a sfidat "destinul" și se bate umăr la umăr cu Silicon Valley”„Apple's R&D center in Israel grew to about 800 employees”„Tim Cook: Apple's Herzliya R&D center second-largest in world”„Lecții de economie de la Israel”„Land use”Israel Investment and Business GuideA Country Study: IsraelCentral Bureau of StatisticsFlorin Diaconu, „Kadima: Flexibilitate și pragmatism, dar nici un compromis în chestiuni vitale", în Revista Institutului Diplomatic Român, anul I, numărul I, semestrul I, 2006, pp. 71-72Florin Diaconu, „Likud: Dreapta israeliană constant opusă retrocedării teritoriilor cureite prin luptă în 1967", în Revista Institutului Diplomatic Român, anul I, numărul I, semestrul I, 2006, pp. 73-74MassadaIsraelul a crescut in 50 de ani cât alte state intr-un mileniuIsrael Government PortalIsraelIsraelIsraelmmmmmXX451232cb118646298(data)4027808-634110000 0004 0372 0767n7900328503691455-bb46-37e3-91d2-cb064a35ffcc1003570400564274ge1294033523775214929302638955X146498911146498911

Image
Mentenanță CS1: Dată și anMentenanță CS1: Utilizare explicită a lui et al.IsraelȚări în Orientul MijlociuRepubliciSionismState membre ale Organizației Națiunilor Unite ebraicăarabărepublică parlamentarăOrientul MijlociuMării MediteraneLibanulSiriaIordaniaCisiordaniaEgiptFâșia GazaIerusalimTel AvivOrganizației Națiunilor Unite14 mai1948Mandatului britanic pentru PalestinaDavid Ben-GurionOrganizației SionisteAgenției Evreiești pentru PalestinaStatului IsraelONULiga ArabăpalestinieneRăzboiul arabo-israelian din 1948Conflict arabo-israelianTransiordaniaEgiptulRăzboiului de Șase ZileCisiordaniaPeninsula SinaiFâșia GazaÎnălțimile GolanBiroului Central de Statisticădruzicerchezisamariteniarmenidemocrație reprezentativăsistem parlamentarvot universalKnessetulgaze naturaleIndicelui Dezvoltării UmaneOCDEȚara I...
Read more

Кастелфранко ди Сопра Становништво Референце Спољашње везе Мени за навигацију43°37′18″ СГШ; 11°33′32″ ИГД / 43.62156° СГШ; 11.55885° ИГД / 43.62156; 11.5588543°37′18″ СГШ; 11°33′32″ ИГД / 43.62156° СГШ; 11.55885° ИГД / 43.62156; 11.558853179688„The GeoNames geographical database”„Istituto Nazionale di Statistica”проширитиууWorldCat156923403n850174324558639-1cb14643287r(подаци)

Image
Acquaborra-CaselleAdattiAlbergoAlberoroAmbraAnatraiaAnciolinaAnghiariAntriaAppaltoArea ProduttivaArezzoArsicciAvenaBaccanelloBadia A RuotiBadia AgnanoBadia PratagliaBadia TedaldaBadia TegaBadia al PinoBadicorteBadiola IBadiola IIBagnaiaBagnolo IBagnolo IIBanzenaBarbianoBarullo-CentoiaBatelliBattifolle-Ruscello-PoggiolaBattifolloBecarinoBeglianoBellavistaBellosguardoBertineBibbianoBibbienaBiccianoBiforcoBigurroBorgaccianoBorghettoBorgo alla CollinaBorgonuovoBorroBossi-CellaioBottegaBrancialinoBucineBugianaBuianoBulcianoBuon RiposoButaleCafaggioCaianoCalbuffaCalcinaiaCallagnoloCalletaCalucacciaCamaldoliCampaccioCampiCampogialliCampoleoneCampolombardoCampoluciCamprenaCamucia-MonsiglioloCapannoleCapezziCapolonaCaposelviCappella BrocchiCappuccini di MontautoCappucciniCapraiaCaprese MichelangeloCaprileCardaCardeta di SopraCarmineCasa BiondoCasa CaroniCasa MarcoCasa MugnainiCasa Vanni - le SelveCasa al CincioCasa alla SisaCasa del ReCasa le BizzeCasacciola-BelvedereCasal GoriCasaleCasalecchio...
Read more