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Pindolol Садржај Farmakologija Reference Literatura Spoljašnje veze Мени за навигацијуMonografijaa68403213523-86-9WHO482891DB009604662BJ4HF6IU1DD00513CHEBI:8214CHEMBL500Goodman & Gilman's The Pharmacological Basis of Therapeutics10.1036/0071422803PDR: Physicians Desk Reference 2010 (Physicians' Desk Reference (Pdr))уу

Бета блокаториИндолиФенолни етриАлкохоли


beta blokatorizoprenalinahinidinaparcijalni agonistantagonist5-HT1A receptora










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Pindolol




Из Википедије, слободне енциклопедије






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Pindolol
Pindolol.svg
IUPAC ime
(RS)-1-(1H-indol-4-iloksi)-3-(izopropilamino)propan-2-ol
Klinički podaciDrugs.com
Monografija
MedlinePlus
a684032
Kategorija trudnoće


  • AU: C


  • US: B (Bez rizika u ispitivanjima na životinjama)


Način primene
oralno, iv

Pravni statusPravni status


  • ℞ (Prescription only)



Farmakokinetički podaciBioraspoloživost
50% do 95%
Metabolizam
Hepatički
Poluvreme eliminacije
3—4 sata
Izlučivanje
Renalno

IdentifikatoriCAS broj

13523-86-9 ДаY
ATC kod

C07AA03 (WHO)
PubChem
CID 4828

IUPHAR/BPS
91
DrugBank

DB00960 ДаY
ChemSpider

4662 ДаY
UNII

BJ4HF6IU1D ДаY
KEGG

D00513 ДаY
ChEBI

CHEBI:8214 ДаY
ChEMBL

CHEMBL500 ДаY
Hemijski podaciFormula

C14H20N2O2
Molarna masa
248,321 g/mol



Pindolol (Visken, Betapindol, Blockin L, Blocklin L, Calvisken, Cardilate, Decreten, Durapindol, Glauco-Visken, Pectobloc, Pinbetol, Prindolol, Pynastin) je beta blokator.[1][2]




Садржај





  • 1 Farmakologija


  • 2 Reference


  • 3 Literatura


  • 4 Spoljašnje veze




Farmakologija


Pindolol je neselektivni beta blokator sa parcijalnom beta-adrenergičkom aktivnošću. On manifestuje intrizičku simpatomimetičku aktivnost. Drugim rečima pindolol, posebno u visokim dozama, ispoljava efekte poput epinefrina ili izoprenalina (povošeni puls i krvni pristisa, bronhodilatacija), mada su ti efekti ograničeni. Pindolol takođe pokazuje membransko stabilišuće dejstvo poput hinidina. On takođe funkcioniše kao slab parcijalni agonist / antagonist 5-HT1A receptora.



Reference




  1. ^ Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803. 


  2. ^ Pdr Staff (2009). PDR: Physicians Desk Reference 2010 (Physicians' Desk Reference (Pdr)). Rozelle, N.S.W: Thomson Reuters. ISBN 1-56363-748-0. 



Literatura



Spoljašnje veze








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Преузето из „https://sr.wikipedia.org/w/index.php?title=Pindolol&oldid=14781912”










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