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Zolmitriptan Reference Literatura Spoljašnje veze Мени за навигацијуMonografija139264-17-8WHO6085760DB00315548442FS66TH3YWD00415CHEBI:10124CHEMBL1185Goodman & Gilman's The Pharmacological Basis of Therapeutics10.1036/0071422803PDR: Physicians Desk Reference 2010 (Physicians' Desk Reference (Pdr))1474327010.1358/dot.1998.34.12.487488Zomig Information Site (USA)уу

ТриптаниОксазолидинониКарбамати


agonist serotoninskog receptoratriptanmigrene










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Zolmitriptan




Из Википедије, слободне енциклопедије






Иди на навигацију
Иди на претрагу


Zolmitriptan
Zolmitriptan Structure V.1.svg
IUPAC ime
(S)-​4-​(3-​[2-​(dimetilamino)​etil]-​1H-​indol-​5-​il​metil)-​1,3-​oksazolidin-​2-​on
Klinički podaciProdajno ime
Zomig
Drugs.com
Monografija
Kategorija trudnoće


  • AU: B3


  • US: C (Mogući rizik)


Način primene
Oralno, nazalni sprej
Pravni statusPravni status



  • US: ℞-only



Farmakokinetički podaciBioraspoloživost
40% (oralno)
Vezivanje proteina
25%
Metabolizam

Hepatički (CYP1A2 posredovano, do aktivnog metabolita)
Poluvreme eliminacije
3 sata
Izlučivanje

Renalno (65%) i fekalno (35%)

IdentifikatoriCAS broj

139264-17-8 ДаY
ATC kod

N02CC03 (WHO)
PubChem
CID 60857

IUPHAR/BPS
60
DrugBank

DB00315 ДаY
ChemSpider

54844 ДаY
UNII

2FS66TH3YW ДаY
KEGG

D00415 ДаY
ChEBI

CHEBI:10124 ДаY
ChEMBL

CHEMBL1185 ДаY
Hemijski podaciFormula

C16H21N3O2
Molarna masa
287,357 g/mol



Zolmitriptan (Zomig, Zomigon, AscoTop, Zomigoro) je selektivan agonist serotoninskog receptora, 1B i 1D podtipova. On je triptan koji se koristi za tretman napada akutne migrene.[1][2]



Reference




  1. ^ Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803. 


  2. ^ Pdr Staff (2009). PDR: Physicians Desk Reference 2010 (Physicians' Desk Reference (Pdr)). Rozelle, N.S.W: Thomson Reuters. ISBN 1-56363-748-0. 



Literatura


.mw-parser-output .refbeginfont-size:90%;margin-bottom:0.5em.mw-parser-output .refbegin-hanging-indents>ullist-style-type:none;margin-left:0.mw-parser-output .refbegin-hanging-indents>ul>li,.mw-parser-output .refbegin-hanging-indents>dl>ddmargin-left:0;padding-left:3.2em;text-indent:-3.2em;list-style:none.mw-parser-output .refbegin-100font-size:100%


  • MacGregor, E.A. (1998). „Zolmitriptan clinical studies”. Drugs Today. 34 (12): 1027—1033. PMID 14743270. doi:10.1358/dot.1998.34.12.487488. 


Spoljašnje veze



  • Zomig Information Site (USA)





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