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CGS-12066A Reference Spoljašnje veze Мени за навигацију109028-10-62689109258810.1007/s00210-004-0951-4у

Агонисти серотонинског рецептораОрганофлуоридиПиперазиниХиноксалини


lekpotentanselektivanagonist5-HT1Breceptora5-HT2










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CGS-12066A




Из Википедије, слободне енциклопедије






Иди на навигацију
Иди на претрагу

















CGS-12066A
CGS-12066A.svg

IUPAC ime
4-(4-metilpiperazin-1-il)-7-(trifluorometil)pirolo[1,2-a]hinoksalin
Identifikatori
CAS broj
109028-10-6 ДаY
ATC kodnone
PubChemCID 2689
IUPHAR/BPS109
ChemSpider2588
Hemijski podaci
Formula
C17H17F3N4
Molarna masa334,338 g/mol



CGS-12066A je lek koji deluje kao potentan i selektivan agonist za 5-HT1B receptora sa nižim afinitetom za tri 5-HT2 receptorska tipa.[1][2] On se koristi za istraživanje uloge 5-HT1B receptora u različitim procesima uključujući percepciju bola, kao i cikluse spavanja i budnost.[3][4]



Reference




  1. ^ Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M. Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Archives of Pharmacology. 2004 Aug;370(2):114-23. doi:10.1007/s00210-004-0951-4 PMID 15322733


  2. ^ Jeong HS, Jang MJ, Park JS. Effects of CGS-12066A on medial vestibular nuclear neurons. Brain Research. 15 March 2005;1038(1):118-21. PMID 15748881


  3. ^ Monti JM, Jantos H. The roles of dopamine and serotonin, and of their receptors, in regulating sleep and waking. Progress in Brain Research. 2008;172:625-46. PMID 18772053


  4. ^ Granados-Soto V, Argüelles CF, Rocha-González HI, Godínez-Chaparro B, Flores-Murrieta FJ, Villalón CM. The role of peripheral 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F serotonergic receptors in the reduction of nociception in rats. Neuroscience. 20 January 2010;165(2):561-8. PMID 19837141



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