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Lesopitron Reference Vidi još Spoljašnje veze Мени за навигацију802654310.1016/0014-2999(94)90097-316032484„Efficacy and safety of lesopitron in outpatients with generalized anxiety disorder”10676820уу

ПиперазиниПиразолиПиримидиниХлороарени


selektivnipun agonist5-HT1A receptorastrukturnoazapironimaanksiolitikgeneralizovanog anksioznog poremećajakliničkih ispitivanjaMPSOPSImeprdsrdodbpasspecspvoprocN5A5B5C6A6B6D










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Lesopitron




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DrugBank =


Lesopitron (E-4424) je selektivni pun agonist 5-HT1A receptora koji je strukturno srodan sa azapironima.[1] On je bio u razvoju kao anksiolitik za tretman generalizovanog anksioznog poremećaja.[2][3] Dospeo je do faze II kliničkih ispitivanja, ali je razvoj prekinut.[2][3]



Reference




  1. ^ Haj-Dahmane S; Jolas T; Laporte AM; et al. (1994). „Interactions of lesopitron (E-4424) with central 5-HT1A receptors: in vitro and in vivo studies in the rat”. European Journal of Pharmacology. 255 (1-3): 185—96. PMID 8026543. doi:10.1016/0014-2999(94)90097-3. CS1 одржавање: Експлицитна употреба et al. (веза)


  2. ↑ 2,02,1 Micheli F (2001). „Lesopitron (Esteve)”. IDrugs : the Investigational Drugs Journal. 4 (2): 218—24. PMID 16032484. 


  3. ↑ 3,03,1 Fresquet A; Sust M; Lloret A; et al. (2000). „Efficacy and safety of lesopitron in outpatients with generalized anxiety disorder”. The Annals of Pharmacotherapy. 34 (2): 147—53. PMID 10676820. CS1 одржавање: Експлицитна употреба et al. (веза)[мртва веза]




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