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Lekozotan Metod dejstva Reference Spoljašnje veze Мени за навигацију434283-16-61115664848854OTZ5ED04683ClinicalTrials„Lecotozan (SRA-333): A selective serotonin1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and promotes procognitive effects”1595139910.1124/jpet.105.086363„Lecozotan Hydrochloride”10.1358/dof.2007.032.05.1092901у

5-ХТ1 антагонистиАнтидеменцијски агенсПиперазиниПиридиниНитрилиБензодиоксиниАцетамиди


Alchajmerove bolestiantagonist5-HT1Areceptoracetilholinaglutamata










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Lekozotan




Из Википедије, слободне енциклопедије






Иди на навигацију
Иди на претрагу

















Lekozotan
Lecozotan structure.svg

IUPAC ime
4-Cijano-N-[(2R)-2-[4-(2,3-dihidro-1,4-benzodioksin-5-il)-1-piperazinil]propil]-N-2-piridinilbenzamid hidrohlorid
Identifikatori
CAS broj
434283-16-6 ДаY
ATC kodnone
PubChemCID 11156648
UNII
48854OTZ5E ДаY
KEGG
D04683 ДаY
Hemijski podaci
Formula
C28H30ClN5O3
Molarna masa520,021 g/mol



Lekozotan potencijalni lek za poboljšanje kognitivnih funkcija kod obolelih od Alchajmerove bolesti.[1][2]



Metod dejstva


Lekozotan je kompetitivni, selektivni antagonist 5-HT1A receptor[3]
koji povišava kalijumom stimulisano otpuštanje acetilholina i glutamata.[4]



Reference




  1. ^ H. Spreitzer (13. 8. 2008). „Neue Wirkstoffe - Lecozotan”. Österreichische Apothekerzeitung (на језику: German) (17/2007): 805. CS1 одржавање: Непрепознат језик (веза)


  2. ^ ClinicalTrials


  3. ^ Schlechter, LE; Smith, DL; Rosenzweig-Lipson, S; Sukoff, SJ; Dawson, LA; Marquis, K; Jones, D; Piesla, M; Andree, T (10. 6. 2005). „Lecotozan (SRA-333): A selective serotonin1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and promotes procognitive effects”. Journal of Pharmacology and Experimental Therapeutics. 314 (3): 1274. PMID 15951399. doi:10.1124/jpet.105.086363. 


  4. ^ Childers, WE Jr, Harrison, BL, Abou-Gharbia, MA, Raje, S, Parks, V, Pangalos, MN, Schechter, LE (2007). „Lecozotan Hydrochloride”. Drugs of the Future. 32 (5): 399—407. doi:10.1358/dof.2007.032.05.1092901. CS1 одржавање: Вишеструка имена: списак аутора (веза)



Spoljašnje veze












Преузето из „https://sr.wikipedia.org/w/index.php?title=Lekozotan&oldid=12331600”










Мени за навигацију


























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