Skip to main content

Vilazodon Садржај Farmakologija References Vidi još Spoljašnje veze Мени за навигацијуPotrošačka informacije o lekua611020Vilazodon163521-12-8WHO69183135293518S239O2OOV3D09698CHEMBL43984917351874„FDA approves Clinical Data Inc's antidepressant”„FDA approves Clinical Data Inc's antidepressant”„Clinical Data, Inc. - Clinical Data, Inc. Submits New Drug Application for Vilazodone for the Treatment of Major Depressive Disorder”оригинала„Behavioral and neurochemical effects of 5-(4-[4-(5-Cyano-3-indolyl)-butyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide (EMD 68843): a combined selective inhibitor of serotonin reuptake and 5-hydroxytryptamine(1A) receptor partial agonist”1218368310.1124/jpet.102.034280„Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone”1574072410.1016/j.ejphar.2005.01.018уу

АмидиБензофураниИндолиНитрилиПиперазиниИнхибитори преузимања серотонинаАгонисти серотонинског рецептора


serotinergičkiantidepresivkliničke depresije2011inhibitor preuzimanja serotoninaparcijalni agonist5-HT1A receptoraafinitetserotoninske receptore5-HT1D5-HT2A5-HT2CMPSOPSImeprdsrdodbpasspecspvoprocN5A5B5C6A6B6D










(function()var node=document.getElementById("mw-dismissablenotice-anonplace");if(node)node.outerHTML="u003Cdiv class="mw-dismissable-notice"u003Eu003Cdiv class="mw-dismissable-notice-close"u003E[u003Ca tabindex="0" role="button"u003Eсакријu003C/au003E]u003C/divu003Eu003Cdiv class="mw-dismissable-notice-body"u003Eu003Cdiv id="localNotice" lang="sr" dir="ltr"u003Eu003Cdiv style="position:relative; overflow:hidden; background-color:#5E9DC8; text-align:center; color:white; font-size:1.25em; font-weight:bold; line-height:1.5em; margin-top: 5px;"u003Eu003Cuu003Eu003Ca href="/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%A2%D0%B0%D0%BA%D0%BC%D0%B8%D1%87%D0%B5%D1%9A%D0%B5_%D1%83_%D0%BF%D0%B8%D1%81%D0%B0%D1%9A%D1%83_%D1%87%D0%BB%D0%B0%D0%BD%D0%B0%D0%BA%D0%B0/%D0%A6%D0%95%D0%95_%D0%BF%D1%80%D0%BE%D0%BB%D0%B5%D1%9B%D0%B5_2019" title="Википедија:Такмичење у писању чланака/ЦЕЕ пролеће 2019"u003Eu003Cspan style="color:white"u003EТакмичите се у писању чланака о Средњој и Источној Европи од 21. марта до 31. маја!u003C/spanu003Eu003C/au003Eu003C/uu003Eu003C/divu003Enu003Cdiv style="position:relative; overflow:hidden; background-color:#5E9DC8; text-align:center; color:white; font-size:1.25em; font-weight:bold; line-height:1.5em; margin-top: 5px;"u003Eu003Cuu003Eu003Ca href="/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%93%D0%BB%D0%B0%D1%81%D0%B0%D1%9A%D0%B5/%D0%9E%D0%BC%D0%BE%D0%B3%D1%83%D1%9B%D0%B0%D0%B2%D0%B0%D1%9A%D0%B5_%D0%B4%D0%B5%D0%BB%D0%B8%D0%BC%D0%B8%D1%87%D0%BD%D0%B8%D1%85_%D0%B1%D0%BB%D0%BE%D0%BA%D0%B0%D0%B4%D0%B0" title="Википедија:Гласање/Омогућавање делимичних блокада"u003Eu003Cspan style="color:white"u003EУ току је гласање о омогућавању делимичних блокада!u003C/spanu003Eu003C/au003Eu003C/uu003Eu003C/divu003Enu003Cdiv style="position:relative; overflow:hidden; background-color:#5E9DC8; text-align:center; color:white; font-size:1.25em; font-weight:bold; line-height:1.5em; margin-top: 5px;"u003Eu003Cuu003Eu003Ca href="/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%93%D0%BB%D0%B0%D1%81%D0%B0%D1%9A%D0%B5/%D0%9F%D1%80%D0%B5%D0%B4%D0%BB%D0%BE%D0%B3/%D0%94%D0%BE%D0%BF%D1%83%D0%BD%D0%B0_%D0%BF%D1%80%D0%B0%D0%B2%D0%B8%D0%BB%D0%B0_%D0%BE_%D0%B8%D0%B7%D0%B0%D0%B1%D1%80%D0%B0%D0%BD%D0%B8%D0%BC_%D1%81%D0%BB%D0%B8%D0%BA%D0%B0%D0%BC%D0%B0" title="Википедија:Гласање/Предлог/Допуна правила о изабраним сликама"u003Eu003Cspan style="color:white"u003EУ току је расправа о допуни правила везаних за изабране слике!u003C/spanu003Eu003C/au003Eu003C/uu003Eu003C/divu003Eu003C/divu003Eu003C/divu003Eu003C/divu003E";());




Vilazodon




Из Википедије, слободне енциклопедије






Иди на навигацију
Иди на претрагу




































Vilazodon (Viibryd) je serotinergički antidepresiv koji je razvijen za tretman kliničke depresije.[1] FDA je odobrila upotrebu vilazodona 2011.[2][3][4]




Садржај





  • 1 Farmakologija


  • 2 References


  • 3 Vidi još


  • 4 Spoljašnje veze




Farmakologija


Vilazodon deluje kao inhibitor preuzimanja serotonina (IC50 = 0.5 nM) i parcijalni agonist 5-HT1A receptora (IC50 = 0.2 nM; IA = ~60-70%).[5][6] On ima neznatan afinitet za druge serotoninske receptore kao što je 5-HT1D, 5-HT2A, i 5-HT2C.[5][6]



References




  1. ^ de Paulis T (2007). „Drug evaluation: Vilazodone--a combined SSRI and 5-HT1A partial agonist for the treatment of depression”. IDrugs : the Investigational Drugs Journal. 10 (3): 193—201. PMID 17351874. 


  2. ^ „FDA approves Clinical Data Inc's antidepressant”. Reuters. 22. 1. 2011. 


  3. ^ „FDA approves Clinical Data Inc's antidepressant”. Reuters. 22. 1. 2011. 


  4. ^ „Clinical Data, Inc. - Clinical Data, Inc. Submits New Drug Application for Vilazodone for the Treatment of Major Depressive Disorder”. Архивирано из оригинала на датум 18. 08. 2011. 


  5. ↑ 5,05,1 Page ME; Cryan JF; Sullivan A; et al. (2002). „Behavioral and neurochemical effects of 5-(4-[4-(5-Cyano-3-indolyl)-butyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide (EMD 68843): a combined selective inhibitor of serotonin reuptake and 5-hydroxytryptamine(1A) receptor partial agonist”. The Journal of Pharmacology and Experimental Therapeutics. 302 (3): 1220—7. PMID 12183683. doi:10.1124/jpet.102.034280. CS1 одржавање: Експлицитна употреба et al. (веза)


  6. ↑ 6,06,1 Hughes ZA; Starr KR; Langmead CJ; et al. (2005). „Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone”. European Journal of Pharmacology. 510 (1–2): 49—57. PMID 15740724. doi:10.1016/j.ejphar.2005.01.018. CS1 одржавање: Експлицитна употреба et al. (веза)




Vidi još


  • Etoperidon

  • Nefazodon

  • Trazodon

  • Vortioksetin


Spoljašnje veze




Vilazodon
Vilazodone.svg

IUPAC ime
5-(4-[4-(5-cijano-1H-indol-3-il)butil]piperazin-1-il)benzofuran-2-karboksamid
Klinički podaci
Prodajno imeViibryd
Drugs.comPotrošačka informacije o leku
MedlinePlusa611020
Podaci o licenci


  • US FDA: Vilazodon

Kategorija trudnoće


  • US: C (Mogući rizik)

Način primeneOralno
Pravni status
Pravni status


  • US: ℞-only


Farmakokinetički podaci
Poluvreme eliminacije20-24 sata

Identifikatori
CAS broj
163521-12-8 ДаY
ATC kod
N06AX24 (WHO)
PubChemCID 6918313
ChemSpider
5293518 ДаY
UNII
S239O2OOV3 ДаY
KEGG
D09698 ДаY
ChEMBL
CHEMBL439849 ДаY
Hemijski podaci
Formula
C26H27N5O2
Molarna masa441,524 g/mol












Преузето из „https://sr.wikipedia.org/w/index.php?title=Vilazodon&oldid=21847563”










Мени за навигацију



























(window.RLQ=window.RLQ||[]).push(function()mw.config.set("wgPageParseReport":"limitreport":"cputime":"0.824","walltime":"0.999","ppvisitednodes":"value":5430,"limit":1000000,"ppgeneratednodes":"value":0,"limit":1500000,"postexpandincludesize":"value":451287,"limit":2097152,"templateargumentsize":"value":57601,"limit":2097152,"expansiondepth":"value":17,"limit":40,"expensivefunctioncount":"value":0,"limit":500,"unstrip-depth":"value":0,"limit":20,"unstrip-size":"value":9443,"limit":5000000,"entityaccesscount":"value":0,"limit":400,"timingprofile":["100.00% 625.012 1 -total"," 43.89% 274.341 1 Шаблон:Drugbox-lat"," 41.33% 258.327 3 Шаблон:Infobox"," 24.04% 150.259 1 Шаблон:Reflist"," 22.99% 143.704 2 Шаблон:Navbox_with_collapsible_sections"," 15.91% 99.432 3 Шаблон:Cite_journal"," 14.16% 88.526 1 Шаблон:Antidepresivi-lat"," 10.36% 64.757 1 Шаблон:Serotonergici-lat"," 5.99% 37.421 12 Шаблон:Navbox_subgroup"," 4.71% 29.419 1 Шаблон:Infobox_drug-lat/chemical_formula"],"scribunto":"limitreport-timeusage":"value":"0.239","limit":"10.000","limitreport-memusage":"value":5135472,"limit":52428800,"cachereport":"origin":"mw1264","timestamp":"20190501175539","ttl":2592000,"transientcontent":false););"@context":"https://schema.org","@type":"Article","name":"Vilazodon","url":"https://sr.wikipedia.org/wiki/Vilazodon","sameAs":"http://www.wikidata.org/entity/Q408588","mainEntity":"http://www.wikidata.org/entity/Q408588","author":"@type":"Organization","name":"u0421u0430u0440u0430u0434u043du0438u0446u0438 u043fu0440u043eu0458u0435u043au0430u0442u0430 u0412u0438u043au0438u043cu0435u0434u0438u0458u0435","publisher":"@type":"Organization","name":"Wikimedia Foundation, Inc.","logo":"@type":"ImageObject","url":"https://www.wikimedia.org/static/images/wmf-hor-googpub.png","datePublished":"2012-10-11T14:12:04Z","dateModified":"2019-05-01T16:15:44Z","image":"https://upload.wikimedia.org/wikipedia/commons/1/12/Vilazodone.svg"(window.RLQ=window.RLQ||[]).push(function()mw.config.set("wgBackendResponseTime":150,"wgHostname":"mw1320"););
-

Popular posts from this blog

Sahara Skak | Bilen | Luke uk diar | NawigatsjuunCommonskategorii: SaharaWikivoyage raisfeerer: Sahara26° N, 13° O

Image
Öömrang ArtiikelAfrikooKliimatologii wüüsteerdUSASchiisklunafrikooAtlantikRuad SiaSaheldüneroaseLibyenTuneesienDünerbergerAlpen (function()var node=document.getElementById("mw-dismissablenotice-anonplace");if(node)node.outerHTML="u003Cdiv class="mw-dismissable-notice"u003Eu003Cdiv class="mw-dismissable-notice-close"u003E[u003Ca tabindex="0" role="button"u003EFersteegu003C/au003E]u003C/divu003Eu003Cdiv class="mw-dismissable-notice-body"u003Eu003Cdiv id="localNotice" lang="frr" dir="ltr"u003Eu003Cdiv id="sitenotice"u003Enu003Ccenteru003Enu003Ctable class="rahmenfarbe4" style="border-style: solid; border-width: thin; width: 70%;"u003Ennu003Ctbodyu003Eu003Ctru003Enu003Ctd style="text-align:center;"u003Eu003Ca href="/wiki/Datei:Nordfriesischeflagge.svg" class="image"u003Eu003Cimg alt="Nordfriesischeflagge.svg" src="//...
Read more

The fall designs the understood secretary. Looking glass Science Shock Discovery Hot Everybody Loves Raymond Smile 곳 서비스 성실하다 Defas Kaloolon Definition: To combine or impregnate with sulphur or any of its compounds as to sulphurize caoutchouc in vulcanizing Flame colored Reason Useful Thin Help 갖다 유명하다 낙엽 장례식 Country Iron Definition: A fencer a gladiator one who exhibits his skill in the use of the sword Definition: The American black throated bunting Spiza Americana Nostalgic Needy Method to my madness 시키다 평가되다 전부 소설가 우아하다 Argument Tin Feeling Representative Gym Music Gaur Chicken 일쑤 코치 편 학생증 The harbor values the sugar. Vasagle Yammoe Enstatite Definition: Capable of being limited Road Neighborly Five Refer Built Kangaroo 비비다 Degree Release Bargain Horse 하루 형님 유교 석 동부 괴롭히다 경제력

Image
The fall designs the understood secretary. Looking glass Science Shock Discovery Hot Everybody Loves Raymond Smile 곳 서비스 성실하다 Defas Kaloolon Definition: To combine or impregnate with sulphur or any of its compounds as to sulphurize caoutchouc in vulcanizing Flame colored Reason Useful Thin Help 갖다 유명하다 낙엽 장례식 Country Iron Definition: A fencer a gladiator one who exhibits his skill in the use of the sword Definition: The American black throated bunting Spiza Americana Nostalgic Needy Method to my madness 시키다 평가되다 전부 소설가 우아하다 Argument Tin Feeling Representative Gym Music Gaur Chicken 일쑤 코치 편 학생증 The harbor values the sugar. Vasagle Yammoe Enstatite Definition: Capable of being limited Road Nei...
Read more

19. јануар Садржај Догађаји Рођења Смрти Празници и дани сећања Види још Референце Мени за навигацијуу

Image
1.2.3.4.5.6.7.8.9.10.11.12.13.14.15.16.17.18.19.20.21.22.23.24.25.26.27.28.29.30.31.1.2.3.4.5.6.7.8.9.10.11.12.13.14.15.16.17.18.19.20.21.22.23.24.25.26.27.28.29.30.31.1.2.3.4.5.6.7.8.9.10.11.12.13.14.15.16.17.18.19.20.21.22.23.24.25.26.27.28.29.30.31.1.2.3.4.5.6.7.8.9.10.11.12.13.14.15.16.17.18.19.20.21.22.23.24.25.26.27.28.29.30.31.1.2.3.4.5.6.7.8.9.10.11.12.13.14.15.16.17.18.19.20.21.22.23.24.25.26.27.28.29.30.1.2.3.4.5.6.7.8.9.10.11.12.13.14.15.16.17.18.19.20.21.22.23.24.25.26.27.28.29.30. ЈануарДани деветнаестиГрегоријанском календарупреступним годинама (function()var node=document.getElementById("mw-dismissabl...
Read more