Vilazodon Садржај
Farmakologija
References
Vidi još
Spoljašnje veze
Мени за навигацијуPotrošačka informacije o lekua611020Vilazodon163521-12-8WHO69183135293518S239O2OOV3D09698CHEMBL43984917351874„FDA approves Clinical Data Inc's antidepressant”„FDA approves Clinical Data Inc's antidepressant”„Clinical Data, Inc. - Clinical Data, Inc. Submits New Drug Application for Vilazodone for the Treatment of Major Depressive Disorder”оригинала„Behavioral and neurochemical effects of 5-(4-[4-(5-Cyano-3-indolyl)-butyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide (EMD 68843): a combined selective inhibitor of serotonin reuptake and 5-hydroxytryptamine(1A) receptor partial agonist”1218368310.1124/jpet.102.034280„Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone”1574072410.1016/j.ejphar.2005.01.018уу
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Vilazodon (Viibryd) je serotinergički antidepresiv koji je razvijen za tretman kliničke depresije.[1] FDA je odobrila upotrebu vilazodona 2011.[2][3][4]
Садржај
1Farmakologija
2References
3Vidi još
4Spoljašnje veze
Farmakologija
Vilazodon deluje kao inhibitor preuzimanja serotonina (IC50 = 0.5 nM) i parcijalni agonist 5-HT1A receptora (IC50 = 0.2 nM; IA = ~60-70%).[5][6] On ima neznatan afinitet za druge serotoninske receptore kao što je 5-HT1D, 5-HT2A, i 5-HT2C.[5][6]
References
^de Paulis T (2007). „Drug evaluation: Vilazodone--a combined SSRI and 5-HT1A partial agonist for the treatment of depression”. IDrugs : the Investigational Drugs Journal. 10 (3): 193—201. PMID 17351874.
^„FDA approves Clinical Data Inc's antidepressant”. Reuters. 22. 1. 2011.
^„FDA approves Clinical Data Inc's antidepressant”. Reuters. 22. 1. 2011.
^„Clinical Data, Inc. - Clinical Data, Inc. Submits New Drug Application for Vilazodone for the Treatment of Major Depressive Disorder”. Архивирано из оригинала на датум 18. 08. 2011.
↑ 5,05,1Page ME; Cryan JF; Sullivan A; et al. (2002). „Behavioral and neurochemical effects of 5-(4-[4-(5-Cyano-3-indolyl)-butyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide (EMD 68843): a combined selective inhibitor of serotonin reuptake and 5-hydroxytryptamine(1A) receptor partial agonist”. The Journal of Pharmacology and Experimental Therapeutics. 302 (3): 1220—7. PMID 12183683. doi:10.1124/jpet.102.034280.CS1 одржавање: Експлицитна употреба et al. (веза)
↑ 6,06,1Hughes ZA; Starr KR; Langmead CJ; et al. (2005). „Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone”. European Journal of Pharmacology. 510 (1–2): 49—57. PMID 15740724. doi:10.1016/j.ejphar.2005.01.018.CS1 одржавање: Експлицитна употреба et al. (веза)
Vidi još
Etoperidon
Nefazodon
Trazodon
Vortioksetin
Spoljašnje veze
Portal Medicina
Portal Hemija
п
р
у
Antidepresivi (N06A)
Specifični inhibitori preuzimanja (RI), pojačavači (RE), i agensi oslobađanja (RA)
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