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SB-216,641 Reference Spoljašnje veze Мени за навигацију170230-39-4329244728930356710.1007/PL000050561515466910.1016/j.neures.2003.11.0041532803510.1016/j.brainres.2004.06.0531739273310.1038/sj.npp.13013961557745110.1097/00008877-200412000-000011572079110.1211/0022357055399у

5-ХТ1 антагонистиОксадиазолиБензанилидиФенолни етри


lekselektivniantagonistserotoninskireceptor5-HT1B5-HT1D receptoranksiolitsko










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SB-216,641




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SB-216,641
SB-216,641 structure.png

IUPAC ime

N-[3-[3-(dimetilamino)etoksi]-4-metoksifenil]-2'-metil-4'-(5-metil-1,2,4-oksadiazol-3-il)-[1,1'-bifenil]-4-karboksamid
Identifikatori
CAS broj
170230-39-4 ДаY
ATC kodnone
PubChemCID 3292447
IUPHAR/BPS28
Hemijski podaci
Formula
C28H30N4O4
Molarna masa486,561 g/mol



SB-216,641 je lek, koji je selektivni antagonist za serotoninski receptor 5-HT1B, sa oko 25x većom selektivnošću u odnosu na srodni 5-HT1D receptor.[1] On se koristi u naučnim istraživanjima,[2][3][4] i pokazano je da ima anksiolitsko dejstvo u životinjskim studijama.[5][6]



Reference




  1. ^ Price, GW; Burton, MJ; Collin, LJ; Duckworth, M; Gaster, L; Göthert, M; Jones, BJ; Roberts, C; Watson, JM (1997). „SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors”. Naunyn-Schmiedeberg's archives of pharmacology. 356 (3): 312—20. PMID 9303567. doi:10.1007/PL00005056. 


  2. ^ Matsuoka, T; Hasuo, H; Akasu, T (2004). „5-Hydroxytryptamine 1B receptors mediate presynaptic inhibition of monosynaptic IPSC in the rat dorsolateral septal nucleus”. Neuroscience research. 48 (3): 229—38. PMID 15154669. doi:10.1016/j.neures.2003.11.004. 


  3. ^ Yan, QS; Zheng, SZ; Yan, SE (2004). „Involvement of 5-HT1B receptors within the ventral tegmental area in regulation of mesolimbic dopaminergic neuronal activity via GABA mechanisms: a study with dual-probe microdialysis”. Brain Research. 1021 (1): 82—91. PMID 15328035. doi:10.1016/j.brainres.2004.06.053. 


  4. ^ Lee, JJ; Hahm, ET; Lee, CH; Cho, YW (2008). „Serotonergic modulation of GABAergic and glutamatergic synaptic transmission in mechanically isolated rat medial preoptic area neurons”. Neuropsychopharmacology. 33 (2): 340—52. PMID 17392733. doi:10.1038/sj.npp.1301396. 


  5. ^ Tatarczyńska, E; Kłodzińska, A; Stachowicz, K; Chojnacka-Wójcik, E (2004). „Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression”. Behavioural Pharmacology. 15 (8): 523—34. PMID 15577451. doi:10.1097/00008877-200412000-00001. 


  6. ^ Chojnacka-Wójcik, E; Kłodzińska, A; Tatarczyńska, E (2005). „The anxiolytic-like effect of 5-HT1B receptor ligands in rats: a possible mechanism of action”. The Journal of pharmacy and pharmacology. 57 (2): 253—7. PMID 15720791. doi:10.1211/0022357055399. 




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Преузето из „https://sr.wikipedia.org/w/index.php?title=SB-216,641&oldid=12331840”










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