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8-OH-DPAT Reference Vidi još Мени за навигацију78950-78-4Interactive imageInteractive image11835036174830131678-Hydroxy-2-(di-N-propylamino)tetralin1220660386610125797verifikuj„8-hydroxy-2-(di-N-propylamino)tetralin - PubChem Public Chemical Database”„PubChem as a public resource for drug discovery.”2097051910.1016/j.drudis.2010.10.003уреди10.1016/S1574-1400(08)00012-1169183210.1016/0028-3908(90)90047-U„8-OH-DPAT as a 5-HT7 agonist: phase shifts of the circadian biological clock through increases in cAMP production”1465409710.1016/j.neuropharm.2003.08.007„IUPHAR DATABASE - 5-Hydroxytryptamine receptors - 5-HT7”„Possible in vivo 5-HT reuptake blocking properties of 8-OH-DPAT assessed by measuring hippocampal extracellular 5-HT using microdialysis in rats”19159468922730157001910.1007/BF00165727уу

Агонисти серотонинског рецептораФенолиТетралини


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8-OH-DPAT




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8-OH-DPAT

Kekulé, skeletal formula of 8-OH-DPAT
Nazivi

IUPAC naziv
8-Hidroksi-2-(di-n-propilamino)tetralin


Sistemski IUPAC naziv
7-(Dipropilamino)-5,6,7,8-tetrahidronaftalen-1-ol[1]

Identifikacija

CAS broj



  • 78950-78-4 ДаY


3D model (Jmol)


  • Interactive image

  • Interactive image


Abrevijacija
8-OH-DPAT

ChemSpider


  • 1183 ДаY


  • 5036174 (R) ДаY


  • 8301316 (S) ДаY



IUPHAR/BPS


  • 7


MeSH

8-Hydroxy-2-(di-N-propylamino)tetralin


PubChem[2][3]CID


  • 1220


  • 6603866 (R)


  • 10125797 (S)





Svojstva

Hemijska formula


C16H25NO

Molarna masa
247,38 g·mol−1

log P
3,711

Kiselost (pKa)
10,539

Baznost (pKb)
3,458
Farmakologija

Farmakokinetika:

Poluvreme eliminacije

1,5 sata

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).


ДаY verifikuj (šta je ДаYНеН ?)

Reference infokutije


8-OH-DPAT je istraživačka hemikalija iz aminotetralinske hemijske klase koja je razvijena tokom 1980-tih i široko korišćena u ispitivanju funkcije 5-HT1A receptora. On je bio jedan od prvih agonista) 5-HT1A receptora.


Originalno se verovalo da je selektivan za 5-HT1A receptor. Kasnije je utvrđeno da 8-OH-DPAT takođe deluje kao agonist 5-HT7 receptora i kao inhibitor serotoninskog preuzimanja/agens serotoninskog otpuštanja.[4][5][6][7][8]



Reference




  1. ^ „8-hydroxy-2-(di-N-propylamino)tetralin - PubChem Public Chemical Database”. The PubChem Project. USA: National Center for Biotechnology Information. 


  2. ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  уреди


  3. ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1. 


  4. ^ Larsson LG, Rényi L, Ross SB, Svensson B, Angeby-Möller K (1990). „Different effects on the responses of functional pre- and postsynaptic 5-HT1A receptors by repeated treatment of rats with the 5-HT1A receptor agonist 8-OH-DPAT”. Neuropharmacology. 29 (2): 85—91. PMID 1691832. doi:10.1016/0028-3908(90)90047-U. 


  5. ^ Sprouse J, Reynolds L, Li X, Braselton J, Schmidt A (2004). „8-OH-DPAT as a 5-HT7 agonist: phase shifts of the circadian biological clock through increases in cAMP production”. Neuropharmacology. 46 (1): 52—62. PMID 14654097. doi:10.1016/j.neuropharm.2003.08.007. 


  6. ^ „IUPHAR DATABASE - 5-Hydroxytryptamine receptors - 5-HT7”. 


  7. ^ Assié MB, Koek W (1996). „Possible in vivo 5-HT reuptake blocking properties of 8-OH-DPAT assessed by measuring hippocampal extracellular 5-HT using microdialysis in rats”. British Journal of Pharmacology. 119 (5): 845—50. PMC 1915946 Слободан приступ. PMID 8922730. 


  8. ^ Wölfel R, Graefe KH (1992). „Evidence for various tryptamines and related compounds acting as substrates of the platelet 5-hydroxytryptamine transporter”. Naunyn-Schmiedeberg's Archives of Pharmacology. 345 (2): 129—36. PMID 1570019. doi:10.1007/BF00165727. 



Vidi još


  • 5-OH-DPAT

  • 7-OH-DPAT

  • Bay R 1531

  • MDAT

  • UH-301











Преузето из „https://sr.wikipedia.org/w/index.php?title=8-OH-DPAT&oldid=12333902”










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