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5-(Noniloksi)triptamin Vidi još Literatura Мени за навигацију157798-12-41797807193110.1021/jm00044a001856882210.1021/jm950498tуу

Агонисти серотонинског рецептораТриптамини


derivattriptaminaagonist5-HT1Dserotoninskogreceptoraafinitet vezivanja










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5-(Noniloksi)triptamin




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5-(Noniloksi)triptamin
5-Nonyloxytryptamine structure.png

IUPAC ime
2-(5-noniloksi-1H-indol-3-il)etanamin
Identifikatori
CAS broj157798-12-4
ATC kodNone
PubChemCID 1797
Hemijski podaci
Formula
C19H30N2O
Molarna masa302,453 g/mol



5-(Noniloksi)triptamin je derivat triptamina koji deluje kao selektivni agonist 5-HT1D serotoninskog receptora. Povećanje dužine O-alkoksi lanca u ovoj seriji generalno povećava potentnost i selektivnost za 5-HT1D. Najveću aktivnost je utvrđeno da ima noniloksi derivat, koji ima 5-HT1Dafinitet vezivanja od 1.0 nM, i koji je oko 300x selektivniji nego za srodni 5-HT1A receptor.[1][2]



Vidi još


  • 5-Benziloksitriptamin

  • 5-Karboksamidotriptamin

  • 5-Etoksi-DMT

  • Sumatriptan


Literatura




  1. ^ Glennon RA, Hong SS, Dukat M, Teitler M, Davis K (1994). „5-(Nonyloxy)tryptamine: a novel high-affinity 5-HT1D beta serotonin receptor agonist”. Journal of Medicinal Chemistry. 37 (18): 2828—30. PMID 8071931. doi:10.1021/jm00044a001. 


  2. ^ Glennon RA, Hong SS, Bondarev M, Law H, Dukat M, Rakhi S, Power P, Fan E, Kinneau D, Kamboj R, Teitler M, Herrick-Davis K, Smith C (1996). „Binding of O-alkyl derivatives of serotonin at human 5-HT1D beta receptors”. Journal of Medicinal Chemistry. 39 (1): 314—22. PMID 8568822. doi:10.1021/jm950498t. 







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