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25I-NBOH Reference Vidi još Spoljašnje veze Мени за навигацију919797-20-91000176181773422117409010.1007/s00259-010-1686-82108898210.1007/s10822-010-9400-21700086310.1124/mol.106.028720у

Психоделични фенетиламиниОрганојодидиФенолиФенолни етриАминиДизајниране дроге


fenetilaminskiagonist5HT2AreceptoraKi2,5-dimetoksi-4-jodoamfetamina










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25I-NBOH




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25I-NBOH
25I-NBOH.svg

IUPAC ime
2-((2-(4-jodo-2,5-dimetoksifenil)etilamino)metil)fenol
Identifikatori
CAS broj
919797-20-9 ДаY
ATC kodnone
PubChemCID 10001761
ChemSpider
8177342 ДаY
Hemijski podaci
Formula
C17H20INO3
Molarna masa413,249 g/mol



25I-NBOH (NBOH-2CI, Cimbi-27) je fenetilaminski halucinogen. On deluje kao potentan agonist 5HT2A receptora,[1][2] sa Ki od 0,061 nM na ljudskom 5HT2A receptoru, te je dvanaest puta potentniji od liganda 2C-I. In vitro testovi su pokazali da ovo jedinjenje deluje kao agonist, ali rezultati životinjskih studija nisu objavljeni. Dok su N-benzilni derivati 2C-I liganda znatno povećavali potentnost, N-benzil derivati 2,5-dimetoksi-4-jodoamfetamina su neaktivni.[3]



Reference




  1. ^ Ettrup, A.; et al. (2010). „Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers”. European Journal of Nuclear Medicine and Molecular Imaging. 38 (4): 681—693. PMID 21174090. doi:10.1007/s00259-010-1686-8. ISBN 0-02-590101686-8. 


  2. ^ Silva ME, Heim R, Strasser A, Elz S, Dove S (2011). „Theoretical studies on the interaction of partial agonists with the 5-HT(2A) receptor”. Journal of Computer-aided Molecular Design. 25 (1): 51—66. PMID 21088982. doi:10.1007/s10822-010-9400-2. 


  3. ^ Braden, MR; Parrish, JC; Naylor, JC; Nichols, DE (2006). „Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists”. Molecular Pharmacology. 70 (6): 1956—64. PMID 17000863. doi:10.1124/mol.106.028720. 



Vidi još


.mw-parser-output .refbeginfont-size:90%;margin-bottom:0.5em.mw-parser-output .refbegin-hanging-indents>ullist-style-type:none;margin-left:0.mw-parser-output .refbegin-hanging-indents>ul>li,.mw-parser-output .refbegin-hanging-indents>dl>ddmargin-left:0;padding-left:3.2em;text-indent:-3.2em;list-style:none.mw-parser-output .refbegin-100font-size:100%


  • 2CBCB-NBOMe (NBOMe-TCB-2)


  • 2CBFly-NBOMe (NBOMe-2CB-Fly)


  • 25B-NBOMe (NBOMe-2CB)


  • 2C-C-NBOMe (NBOMe-2CC)


  • 25I-NBMD (NBMD-2CI)


  • 25I-NBOMe (NBOMe-2CI)


  • 2C-TFM-NBOMe (NBOMe-2C-TFM)


  • 25I-NBF (NBF-2CI)



Spoljašnje veze











Преузето из „https://sr.wikipedia.org/w/index.php?title=25I-NBOH&oldid=20030473”










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