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LY-334,370 Vidi još Literatura Spoljašnje veze Мени за навигацију182563-08-2Interactive image205311258verifikuj„PubChem as a public resource for drug discovery.”2097051910.1016/j.drudis.2010.10.003уреди10.1016/S1574-1400(08)00012-1964154410.1038/sj.bjp.07018321066810310.1046/j.1468-2982.1999.1910851.x1167506110.1016/S0140-6736(01)06347-41679771610.1016/j.pharmthera.2005.04.0104-fluoro-N-(3-(1-methyl-4-piperidinyl)-1H-indol-5-yl)benzamideу

Агонисти серотонинског рецептораИндолиПиперидиниБензамидиОрганофлуориди


agonist5-HT1FEli Lili i kompanijamigrensketoksičnosti










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LY-334,370




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LY-334,370

LY334370.svg
Nazivi

IUPAC naziv
4-fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide

Drugi nazivi
LY-334,370

Identifikacija

CAS broj


  • 182563-08-2


3D model (Jmol)


  • Interactive image


IUPHAR/BPS


  • 20



PubChem[1][2]CID


  • 5311258



Svojstva

Hemijska formula

C21H22FN3O

Molarna masa
351.42 g/mol

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).


ДаY verifikuj (šta je ДаYНеН ?)

Reference infokutije


LY-334,370 je selektivni agonist 5-HT1F receptora[3] koga razvija Eli Lili i kompanija za lečenje migrenske glavobolje.[4] Lek je pokazao efikasnost u fazi II kliničkih ispitivanja,[5] ali je dalji razvoj zaustavljen usled ustanovljene toksičnosti u životinjskim ispitivanjima.[6]



Vidi još



  • Lasmiditan, 5-HT1F agonist za lečenje migrene


Literatura




  1. ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  уреди


  2. ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1. 


  3. ^ Dupuis DS, Colpaert FC, Pauwels PJ (1998). „G-protein activation at 5-HT1A receptors by the 5-HT1F ligand LY-334,370 in guinea-pig brain sections and recombinant cell lines”. Br. J. Pharmacol. 124 (2): 283—90. PMID 9641544. doi:10.1038/sj.bjp.0701832. 


  4. ^ Shepheard S, Edvinsson L, Cumberbatch M, Williamson D, Mason G, Webb J, Boyce S, Hill R, Hargreaves R (1999). „Possible antimigraine mechanisms of action of the 5HT1F receptor agonist LY-334,370”. Cephalalgia. 19 (10): 851—8. PMID 10668103. doi:10.1046/j.1468-2982.1999.1910851.x. 


  5. ^ Goldstein DJ, Roon KI, Offen WW, Ramadan NM, Phebus LA, Johnson KW, Schaus JM, Ferrari MD (2001). „Selective seratonin 1F (5-HT1F) receptor agonist LY334370 for acute migraine: a randomised controlled trial”. Lancet. 358 (9289): 1230—4. PMID 11675061. doi:10.1016/S0140-6736(01)06347-4. 


  6. ^ Ramadan NM, Buchanan TM (2006). „New and future migraine therapy”. Pharmacol. Ther. 112 (1): 199—212. PMID 16797716. doi:10.1016/j.pharmthera.2005.04.010. 



Spoljašnje veze




  • MeSH 4-fluoro-N-(3-(1-methyl-4-piperidinyl)-1H-indol-5-yl)benzamide




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