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Rakloprid Reference Spoljašnje veze Мени за навигацију84225-95-63033769942298373430K3SOZ7GCHEMBL8809401567410.1016/0006-2952(85)90778-6902465610.1038/385590a0ChemSpiderу

Типични антипсихотициДопамински антагонистиБензамидиПиролидиниФенолни етриХлороарениАмиди


antagonistdopaminskom receptoruradioizotopompozitronskom emisiono tomografskomdopaminskogD2 dopaminskireceptor










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Rakloprid




Из Википедије, слободне енциклопедије






Иди на навигацију
Иди на претрагу























Rakloprid
Raclopride.png

IUPAC ime
3,5-dihlor-N[(2S)-1-etilpirolidin-2-il]metil2-hidroksi-6-metoksibenzamid

Farmakokinetički podaci
Poluvreme eliminacije30 min

Identifikatori
CAS broj
84225-95-6 ДаY
ATC kodnone
PubChemCID 3033769
IUPHAR/BPS94
ChemSpider
2298373 ДаY
UNII
430K3SOZ7G ДаY
ChEMBL
CHEMBL8809 ДаY
Hemijski podaci
Formula
C15H20Cl2N2O3
Molarna masa347,236 g/mol



Rakloprid je sintetičko jedinjenje koje deluje kao antagonist na D2 dopaminskom receptoru.[1]
On se može radio obeležiti radioizotopom ugljenik-11 i koristiti u pozitronskom emisiono tomografskom (PET) skeniranju za utvrđivanje stepena dopaminskog vezivanja za D2 dopaminski receptor. Na primer, jedna studija je utvrdila da postoji umanjeno vezivanje kod osoba sa emocionom otuđenošću.[2]



Reference




  1. ^ C. Kohler; H. Hall; S. O. Ogren; L. Gawell (1985). „Specific in vitro and in vivo binding of 3H-raclopride. A potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain”. Biochemical Pharmacology. 34 (13): 2251—2259. PMID 4015674. doi:10.1016/0006-2952(85)90778-6. 


  2. ^ Lars Farde; J. Petter Gustavsson; Erik Jönsson (1997). „D2 dopamine receptors and personality traits”. Nature. 385 (6617): 590. PMID 9024656. doi:10.1038/385590a0. 



Spoljašnje veze



  • ChemSpider




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Преузето из „https://sr.wikipedia.org/w/index.php?title=Rakloprid&oldid=15618669”










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