Rakloprid Reference Spoljašnje veze Мени за навигацију84225-95-63033769942298373430K3SOZ7GCHEMBL8809401567410.1016/0006-2952(85)90778-6902465610.1038/385590a0ChemSpiderу
Типични антипсихотициДопамински антагонистиБензамидиПиролидиниФенолни етриХлороарениАмиди
antagonistdopaminskom receptoruradioizotopompozitronskom emisiono tomografskomdopaminskogD2 dopaminskireceptor
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Rakloprid
Иди на навигацију
Иди на претрагу
 | |
IUPAC ime | |
|---|---|
3,5-dihlor-N[(2S)-1-etilpirolidin-2-il]metil2-hidroksi-6-metoksibenzamid | |
Farmakokinetički podaci | |
| Poluvreme eliminacije | 30 min |
| Identifikatori | |
| CAS broj | 84225-95-6  Y |
| ATC kod | none |
| PubChem | CID 3033769 |
| IUPHAR/BPS | 94 |
| ChemSpider | 2298373 Y |
| UNII | 430K3SOZ7G Y |
| ChEMBL | CHEMBL8809 Y |
| Hemijski podaci | |
| Formula | C15H20Cl2N2O3 |
| Molarna masa | 347,236 g/mol |
SMILES
| |
InChI
| |
Rakloprid je sintetičko jedinjenje koje deluje kao antagonist na D2 dopaminskom receptoru.[1]
On se može radio obeležiti radioizotopom ugljenik-11 i koristiti u pozitronskom emisiono tomografskom (PET) skeniranju za utvrđivanje stepena dopaminskog vezivanja za D2 dopaminski receptor. Na primer, jedna studija je utvrdila da postoji umanjeno vezivanje kod osoba sa emocionom otuđenošću.[2]
Reference
^ C. Kohler; H. Hall; S. O. Ogren; L. Gawell (1985). „Specific in vitro and in vivo binding of 3H-raclopride. A potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain”. Biochemical Pharmacology. 34 (13): 2251—2259. PMID 4015674. doi:10.1016/0006-2952(85)90778-6.
^ Lars Farde; J. Petter Gustavsson; Erik Jönsson (1997). „D2 dopamine receptors and personality traits”. Nature. 385 (6617): 590. PMID 9024656. doi:10.1038/385590a0.
Spoljašnje veze
- ChemSpider
 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
Категорије:
- Типични антипсихотици
- Допамински антагонисти
- Бензамиди
- Пиролидини
- Фенолни етри
- Хлороарени
- Амиди
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