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Metilfenidat Reference Literatura Spoljašnje veze Мени за навигацијуMonografijaa682188Methylphenidate113-45-1WHO4158DB004224015207ZZ9QZ49D04999CHEBI:6887CHEMBL796When Was Ritalin Invented?The history of attention deficit hyperactivity disorder„F.D.A. Finds Short Supply of Attention Deficit Drugs”Архивирано„The impact of prescribed psychotropics on youth”21000411794950410.1186/1745-0179-3-21New Research Helps Explain Ritalin's Low Abuse Potential When Taken As Prescribed – 09/29/1998„The myth of attention deficit-hyperactivity disorder: symptoms resulting from multiple causes”146925510.1177/088307389200700420„Are we over medicating our kids? Speaking with Dr. Harold Koplewicz of @ChildMindDotOrg”оригиналаMetilfenidatDepartment of Energy September 29, 1998 press release on RitalinErowid methylphenidate vaultU.S. National Library of Medicine: Drug Information Portal – Methylphenidateуууsh91001552

3-PPP4-PPBP5-MeO-DMTAlazocin (SKF-10047)AmantadinANAVEX2-73ArketaminBD-737BD-1052KaptodiamCitalopramCGRPKloperastinKokainKutamezin (SA-4503)CiklazocinDehidroepiandrosteron (DHEA)prasteronDehidroepiandrosteron sulfat (DHEA-S)prasteron sulfatDekstralorfanDekstrometorfan (DXM)Dekstrorfan (DXO)DimemorfanDimetiltriptamin (DMT)Ditolilgvanidin (DTG)DonepezilEliprodilEscitalopramFabomotizol (afobazol)FluoksetinFluvoksaminIfenprodilIgmesin (JO-1784)IPABKetaminL-687384MDMA (midomafetamin)MemantinMetamfetaminMetoksetaminMetilfenidatNepinalonNeuropeptid YNoskapinOPC-14523OpipramolPentazocinPentoksiverin (karbetapentan)PRE-084PregnenolonPregnenolon sulfatPridopidinRacemetorfan (metorfan)Racemorfan (morfanol)UMB-23UMB-823-PPPAC-927BD-1008BD-1031BD-1047BD-1060BD-1063BD-1067BMY-14802 (BMS-181100)CM-156Dup-734E-5842E-52862 (S1RA)HaloperidolLR-132LR-172MS-377NE-100NPC-16377Panamesin (EMD-57455)PD-144418PentazocinProgesteronRimkazol (BW-234U)SertralinSR-31742AFenitoinMetilfenilpiracetamSOMCL-6683-Metoksidekstralorfan3-MeO-PCP4C-T-24-IBP4-IPBS4-MeO-PCP5-MeO-DALT5-MeO-DiPTAmitriptilinAzidopamilHlorpromazinKlemastinKlomipraminKlorgilinD-DeprenilDiPTDPTIbogainImipraminKCR-12-83.1NemonapridNoribogainRHL-033RS-67,333RTI-55ŠafranSafinamidSelegilinSpipetijanTrifluoperazinW-18YKP10ABerberinEtilketazocinForfitMetafitNalbufinNaluzotanTapentadolTenociklidinAHD1AZ66LamotriginNaloksonSM-21UMB-100UMB-101UMB-103UMB-116YZ-011YZ-069YZ-185SKF-8395918-MetoksikoronaridinBMY-13980ButaklamolKaramifenKarvotrolinHlorfenamin (hlorfeniramin)HlorpromazinCinarizinCinuperonKlocapraminDezocinEMD-59983HipericinkantarionFlufenazinGevotrolin (WY-47384)Mepiramin (pirilamin)MolindonPerfenazinPimozidProadifenPrometazinPropranololHinidinRemoksipridSL 82.0715SR-31747ATiospiron (BMY-13859)Venlafaksin


Карбоксилатни естриБиологија биполарног поремећајаМетил естриНоотропициИнхибитори норепинефрин-допаминског преузимањаПиперидиниСтимулантиСимпатомиметички аминиЕуфоријантиВазоконстрикториЛечење и управљање хиперкинетичким поремећајем


psihostimulišućileksupstituisani fenetilamintretmanhiperkinetičkog poremećajaposturalnog ortostatskog tahikardnog sindromanarkolepsijeCIBAFDA1955Metilfenidat










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Metilfenidat




Из Википедије, слободне енциклопедије






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Metilfenidat (Concerta, Methylin, Ritalin, Equasym XL) je psihostimulišući lek i supstituisani fenetilamin koji je odobren tretman hiperkinetičkog poremećaja (ADHD), posturalnog ortostatskog tahikardnog sindroma i narkolepsije. Originalni patent je posedovalo preduzeće CIBA. FDA je odobrila ovaj lek 1955. za tretiranje hiperaktivnosti. Propisivan je od početka 1960-tih. Nivo proskripcija je znatno porastao tokom 1990-tih kad je ADHD dijagnoza postala šire prihvaćena.[1][2]



Reference




  1. ^ When Was Ritalin Invented?, citing Lawrence Diller: "Running on Ritalin", 1999


  2. ^ Lange, K.W. et al.: The history of attention deficit hyperactivity disorder. In: Attention Deficit Hyperactivity Disorders, 2(4):241-55. doi: 10.1007/s12402-010-0045-8.




Literatura



  • Gardiner Harris (3. 2. 2012). „F.D.A. Finds Short Supply of Attention Deficit Drugs”. The New York Times. Архивирано из оригинала на датум 03. 02. 2012. Приступљено 3. 2. 2012. »(Archived by WebCite® at [1])« 


  • Lakhan SE, Hagger-Johnson GE (2007). „The impact of prescribed psychotropics on youth”. Clin Pract Epidemol Ment Health. 3 (1): 21. PMC 2100041 Слободан приступ. PMID 17949504. doi:10.1186/1745-0179-3-21. 

  • Drug Enforcement Administration, Greene, S.H., Response to CHADD petition concerning Ritalin, 1995, August 7. Washington, DC: DEA, U.S. Department of Justice.


  • New Research Helps Explain Ritalin's Low Abuse Potential When Taken As Prescribed – 09/29/1998. Nih.gov. Retrieved on 2011-04-30.


  • Weinberg WA, Brumback RA (1992). „The myth of attention deficit-hyperactivity disorder: symptoms resulting from multiple causes”. J. Child Neurol. 7 (4): 431—45; discussion 446—61. PMID 1469255. doi:10.1177/088307389200700420. [мртва веза]


  • Presenters: Joan Hamburg and Dr. Harold Koplewicz (3. 2. 2012). „Are we over medicating our kids? Speaking with Dr. Harold Koplewicz of @ChildMindDotOrg”. Joan Hamburg Show (Radio). New York, NY. 1:11 into the complete two part show - 2 мин. WOR Radio Network. WOR. Архивирано из оригинала на датум 03. 12. 2012. Приступљено 10. 12. 2013. 


Spoljašnje veze


Mediji vezani za članak Metilfenidat na Vikimedijinoj ostavi



  • Metilfenidat на сајту DMOZ (на језику: енглески)


  • Department of Energy September 29, 1998 press release on Ritalin at Brookhaven National Laboratory

  • Erowid methylphenidate vault

  • U.S. National Library of Medicine: Drug Information Portal – Methylphenidate

Metilfenidat
Methylphenidate-2D-skeletal.svg
Methylphenidate3Dan.gif

IUPAC ime
metil fenil(piperidin-2-il)acetat
Klinički podaci
Prodajno imeConcerta, Methylin, Ritalin, Equasym XL
Drugs.comMonografija
MedlinePlusa682188
Podaci o licenci


  • US FDA: Methylphenidate

Kategorija trudnoće


  • AU: B3


  • US: C (Mogući rizik)


Opojna drogaModerate
Način primeneOralno, transdermalno
Pravni status
Pravni status


  • AU: S8 (Kontrolisana supst.)


  • CA: Schedule III


  • UK: Klasa B


  • US: Schedule II



Farmakokinetički podaci
Bioraspoloživost~30% (opseg: 11–52%)
Vezivanje proteina10-33%
Metabolizam
Hepatički (80%)
Poluvreme eliminacije3-4 sata (d-enantiomer), 1-3 sata (l-enantiomer)
Izlučivanje
Urin (90%)

Identifikatori
CAS broj
113-45-1 ДаY
ATC kod
N06BA04 (WHO)
PubChemCID 4158
DrugBank
DB00422 ДаY
ChemSpider
4015 ДаY
UNII
207ZZ9QZ49 ДаY
KEGG
D04999 ДаY
ChEBI
CHEBI:6887 ДаY
ChEMBL
CHEMBL796 ДаY
Hemijski podaci
Formula
C14H19NO2
Molarna masa233,30 g/mol



Fizički podaci
Tačka topljenja
214 °C (417 °F)


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