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Sarizotan Reference Vidi još Spoljašnje veze Мени за навигацију177975-08-569183882319847467LU0UCUW1223662410.1177/0269881102016003011598783410.1124/jpet.105.0871631739314410.1007/s00213-007-0762-7117232721476771510.1007/s00702-003-0094-71579163410.1002/mds.203701919654010.1016/j.parkreldis.2008.11.001ууу

АминиПиридиниОрганофлуоридиХромани


selektivniagonist5-HT1A receptorantagonistD2 receptoraantipsihotičkimdiskinezijuParkinsonove bolestilevodopomAzaperonBenperidolBromperidolDroperidolFluanizonHaloperidolLenperonMoperonPipamperonSpiperonTimiperonTrifluperidolKlopimozidFluspirilenPenfluridolPimozidAcepromazinAcetofenazinButaperazinKarfenazinHloracizinHlorproetazinHlorpromazinCijamemazinDiksirazinFluacizinFlufenazinLevomepromazin/MetotrimeprazinMezoridazinPerazinPericijazinPerfenazinPiperacetazinPipotiazinProhlorperazinPromazinPrometazinPropiomazinSulforidazinTietilperazinTiopropazatTioproperazinTioridazinTrifluoperazinTriflupromazinHlorprotiksenKlopentiksolFlupentiksolTiotiksenZuklopentiksolButaklamolFluotracenLoksapinTrimipraminCinuperonMelperonSetoperonIloperidonOkaperidonPaliperidonRisperidonLurasidonePerospironRevospironTiospironZiprasidonAmperozidAripiprazolBifeprunoksBrekspiprazolElopiprazolUmespironAmoksapinAsenapinKarpipraminKlocapraminKlorotepinKlotiapinKlozapinFluperlapinGevotrolinMetitepinMosapraminNDMCOlanzapinPihindonKvetijapinTenilapinZotepinWHO-EMPovučeniKlinička ispitivanjaFaza IIINije dospeo do faze IIIMPSOPSImeprdsrdodbpasspecspvoprocN5A5B5C6A6B6D










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Sarizotan




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Sarizotan
Sarizotan.png

IUPAC ime
1-[(2R)-3,4-dihidro-2H-hromen-2-il]-N-([5-(4-fluorofenil)pyridin-3-il]metil)metanamin
Klinički podaci
Kategorija trudnoće

  • N/A
Način primeneOralno
Identifikatori
CAS broj
177975-08-5 ДаY
ATC kodnone
PubChemCID 6918388
ChemSpider2319847
UNII
467LU0UCUW ДаY
Hemijski podaci
Formula
C22H21FN2O
Molarna masa348,413 g/mol



Sarizotan (EMD-128,130) je selektivni agonist 5-HT1A receptor i antagonist D2 receptora,[1] sa antipsihotičkim dejstvom.[2][3] Takođe je poznato da redukuje diskineziju kod dugotrajnih tretmana Parkinsonove bolesti sa levodopom.[4][5][6][7]



Reference




  1. ^ Rabiner, E. A.; Gunn, R. N.; Wilkins, M. R.; Sedman, E.; Grasby, P. M. (2002). „Evaluation of EMD 128 130 occupancy of the 5-HT1A and the D2 receptor: a human PET study with 11CWAY-100635 and 11Craclopride”. Journal of psychopharmacology (Oxford, England). 16 (3): 195—199. PMID 12236624. doi:10.1177/026988110201600301. }


  2. ^ Assié, M.; Ravailhe, V.; Faucillon, V.; Newman-Tancredi, A. (2005). „Contrasting contribution of 5-hydroxytryptamine 1A receptor activation to neurochemical profile of novel antipsychotics: frontocortical dopamine and hippocampal serotonin release in rat brain”. The Journal of Pharmacology and Experimental Therapeutics. 315 (1): 265—272. PMID 15987834. doi:10.1124/jpet.105.087163. 


  3. ^ Auclair, A.; Galinier, A.; Besnard, J.; Newman-Tancredi, A.; Depoortère, R. (2007). „Putative antipsychotics with pronounced agonism at serotonin 5-HT1A and partial agonist activity at dopamine D2 receptors disrupt basal PPI of the startle reflex in rats”. Psychopharmacology. 193 (1): 45—54. PMID 17393144. doi:10.1007/s00213-007-0762-7. 


  4. ^ Bibbiani, F.; Oh, J. D.; Chase, T. N. (2001). „Serotonin 5-HT1A agonist improves motor complications in rodent and primate parkinsonian models”. Neurology. 57 (10): 1829—1834. PMID 11723272. 


  5. ^ Bartoszyk, G.; Van Amsterdam, C.; Greiner, H.; Rautenberg, W.; Russ, H.; Seyfried, C. (2004). „Sarizotan, a serotonin 5-HT1A receptor agonist and dopamine receptor ligand. 1. Neurochemical profile”. Journal of neural transmission (Vienna, Austria : 1996). 111 (2): 113—126. PMID 14767715. doi:10.1007/s00702-003-0094-7. 


  6. ^ Bara-Jimenez, W.; Bibbiani, F.; Morris, M.; Dimitrova, T.; Sherzai, A.; Mouradian, M.; Chase, T. (2005). „Effects of serotonin 5-HT1A agonist in advanced Parkinson's disease”. Movement disorders : official journal of the Movement Disorder Society. 20 (8): 932—936. PMID 15791634. doi:10.1002/mds.20370. 


  7. ^ Grégoire, L.; Samadi, P.; Graham, J.; Bédard, P.; Bartoszyk, G.; Di Paolo, T. (2009). „Low doses of sarizotan reduce dyskinesias and maintain antiparkinsonian efficacy of L-Dopa in parkinsonian monkeys”. Parkinsonism & related disorders. 15 (6): 445—452. PMID 19196540. doi:10.1016/j.parkreldis.2008.11.001. 



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Ethnic groups”„Jews, by country of origin and age”„Minority Communities in Israel: Background & Overview”„Israel”„Language in Israel”„Selected Data from the 2011 Social Survey on Mastery of the Hebrew Language and Usage of Languages”„Religions”„5 facts about Israeli Druze, a unique religious and ethnic group”„Israël”Israel Country Study Guide„Haredi city in Negev – blessing or curse?”„New town Harish harbors hopes of being more than another Pleasantville”„List of localities, in alphabetical order”„Muncitorii români, doriți în Israel”„Prietenia româno-israeliană la nevoie se cunoaște”„The Higher Education System in Israel”„Middle East”„Academic Ranking of World Universities 2016”„Israel”„Israel”„Jewish Nobel Prize Winners”„All Nobel Prizes in Literature”„All Nobel Peace Prizes”„All Prizes in Economic Sciences”„All Nobel Prizes in Chemistry”„List of Fields Medallists”„Sakharov Prize”„Țara care și-a sfidat "destinul" și se bate umăr la umăr cu Silicon Valley”„Apple's R&D center in Israel grew to about 800 employees”„Tim Cook: Apple's Herzliya R&D center second-largest in world”„Lecții de economie de la Israel”„Land use”Israel Investment and Business GuideA Country Study: IsraelCentral Bureau of StatisticsFlorin Diaconu, „Kadima: Flexibilitate și pragmatism, dar nici un compromis în chestiuni vitale", în Revista Institutului Diplomatic Român, anul I, numărul I, semestrul I, 2006, pp. 71-72Florin Diaconu, „Likud: Dreapta israeliană constant opusă retrocedării teritoriilor cureite prin luptă în 1967", în Revista Institutului Diplomatic Român, anul I, numărul I, semestrul I, 2006, pp. 73-74MassadaIsraelul a crescut in 50 de ani cât alte state intr-un mileniuIsrael Government PortalIsraelIsraelIsraelmmmmmXX451232cb118646298(data)4027808-634110000 0004 0372 0767n7900328503691455-bb46-37e3-91d2-cb064a35ffcc1003570400564274ge1294033523775214929302638955X146498911146498911

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Mentenanță CS1: Dată și anMentenanță CS1: Utilizare explicită a lui et al.IsraelȚări în Orientul MijlociuRepubliciSionismState membre ale Organizației Națiunilor Unite ebraicăarabărepublică parlamentarăOrientul MijlociuMării MediteraneLibanulSiriaIordaniaCisiordaniaEgiptFâșia GazaIerusalimTel AvivOrganizației Națiunilor Unite14 mai1948Mandatului britanic pentru PalestinaDavid Ben-GurionOrganizației SionisteAgenției Evreiești pentru PalestinaStatului IsraelONULiga ArabăpalestinieneRăzboiul arabo-israelian din 1948Conflict arabo-israelianTransiordaniaEgiptulRăzboiului de Șase ZileCisiordaniaPeninsula SinaiFâșia GazaÎnălțimile GolanBiroului Central de Statisticădruzicerchezisamariteniarmenidemocrație reprezentativăsistem parlamentarvot universalKnessetulgaze naturaleIndicelui Dezvoltării UmaneOCDEȚara I...
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Кастелфранко ди Сопра Становништво Референце Спољашње везе Мени за навигацију43°37′18″ СГШ; 11°33′32″ ИГД / 43.62156° СГШ; 11.55885° ИГД / 43.62156; 11.5588543°37′18″ СГШ; 11°33′32″ ИГД / 43.62156° СГШ; 11.55885° ИГД / 43.62156; 11.558853179688„The GeoNames geographical database”„Istituto Nazionale di Statistica”проширитиууWorldCat156923403n850174324558639-1cb14643287r(подаци)

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Acquaborra-CaselleAdattiAlbergoAlberoroAmbraAnatraiaAnciolinaAnghiariAntriaAppaltoArea ProduttivaArezzoArsicciAvenaBaccanelloBadia A RuotiBadia AgnanoBadia PratagliaBadia TedaldaBadia TegaBadia al PinoBadicorteBadiola IBadiola IIBagnaiaBagnolo IBagnolo IIBanzenaBarbianoBarullo-CentoiaBatelliBattifolle-Ruscello-PoggiolaBattifolloBecarinoBeglianoBellavistaBellosguardoBertineBibbianoBibbienaBiccianoBiforcoBigurroBorgaccianoBorghettoBorgo alla CollinaBorgonuovoBorroBossi-CellaioBottegaBrancialinoBucineBugianaBuianoBulcianoBuon RiposoButaleCafaggioCaianoCalbuffaCalcinaiaCallagnoloCalletaCalucacciaCamaldoliCampaccioCampiCampogialliCampoleoneCampolombardoCampoluciCamprenaCamucia-MonsiglioloCapannoleCapezziCapolonaCaposelviCappella BrocchiCappuccini di MontautoCappucciniCapraiaCaprese MichelangeloCaprileCardaCardeta di SopraCarmineCasa BiondoCasa CaroniCasa MarcoCasa MugnainiCasa Vanni - le SelveCasa al CincioCasa alla SisaCasa del ReCasa le BizzeCasacciola-BelvedereCasal GoriCasaleCasalecchio...
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