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Ro10-5824 Reference Spoljašnje veze Мени за навигацију189744-46-5167591751264628410.1016/S0028-3908(02)00412-41789748310.1017/S1461145707008061у

Допамински агонистиТетрахидропиридиниПиримидиниАмини


dopaminski agonistparcijalni agonistD4










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Ro10-5824




Из Википедије, слободне енциклопедије






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Ro10-5824
Ro10-5824 structure.png

IUPAC ime
2-metil-5-[(4-fenil-3,6-dihidro-2H-piridin-1-il)metil]pirimidin-4-amin
Identifikatori
CAS broj
189744-46-5 ДаY
ATC kodnone
PubChemCID 16759175
Hemijski podaci
Formula
C17H20N4
Molarna masa280,367 g/mol



Ro10-5824 je lek koji deluje kao dopaminski agonist. On je selektivni parcijalni agonist D4 podtipa. Ro10-5824 deluje kao kognitivni pojačivač u životinjskim studijama.[1][2]



Reference




  1. ^ Powell SB, Paulus MP, Hartman DS, Godel T, Geyer MA (2003). „RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice”. Neuropharmacology. 44 (4): 473—81. PMID 12646284. doi:10.1016/S0028-3908(02)00412-4. 


  2. ^ Newman-Tancredi A, Heusler P, Martel JC, Ormière AM, Leduc N, Cussac D (2008). „Agonist and antagonist properties of antipsychotics at human dopamine D4.4 receptors: G-protein activation and K+ channel modulation in transfected cells”. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (CINP). 11 (3): 293—307. PMID 17897483. doi:10.1017/S1461145707008061. 



Spoljašnje veze












Преузето из „https://sr.wikipedia.org/w/index.php?title=Ro10-5824&oldid=12336078”










Мени за навигацију


























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