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L-745,870 Reference Spoljašnje veze Мени за навигацију158985-00-3531120092269941513844710.1038/sj.npp.1300491„Effects of dopamine D4 receptor antagonist on spontaneous alternation in rats”25770921894533410.1186/1744-9081-4-49у

Допамински антагонистиПиролопиридиниПиперазиниХлороарени


dopaminski antagonistparcijalni agonistD4antipsihotično










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L-745,870




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L-745,870
L-745870 structure.png

IUPAC ime
3-([4-(4-hlorofenil)piperazin-1-il]metil)-1H-pirolo[2,3-b]piridin
Identifikatori
CAS broj
158985-00-3 ДаY
ATC kodnone
PubChemCID 5311200
Hemijski podaci
Formula
C18H19ClN4
Molarna masa326,822 g/mol



L-745,870 je lek koji deluje kao dopaminski antagonist. On je selektivni parcijalni agonist D4 podtipa. L-745,870 ima antipsihotično dejstvo u životinjskim modelima. On nije pokazao taj efekat u kliničkim ispitivanjima.[1][2][3]



Reference




  1. ^ Bristow LJ, Kramer MS, Kulagowski J, Patel S, Ragan CI, Seabrook GR (1997). „Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist”. Trends in Pharmacological Sciences. 18 (6): 186—8. PMID 9226994. 


  2. ^ Zhang K, Grady CJ, Tsapakis EM, Andersen SL, Tarazi FI, Baldessarini RJ (2004). „Regulation of working memory by dopamine D4 receptor in rats”. Neuropsychopharmacology. 29 (9): 1648—55. PMID 15138447. doi:10.1038/sj.npp.1300491. 


  3. ^ Moustgaard A, Hau J, Lind NM (2008). „Effects of dopamine D4 receptor antagonist on spontaneous alternation in rats”. Behavioral and Brain Functions. 4: 49. PMC 2577092 Слободан приступ. PMID 18945334. doi:10.1186/1744-9081-4-49. 



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