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Tergurid Reference Spoljašnje veze Мени за навигацијуInternacionalno ime leka37686-84-3WHO4439515621OJT43Q88D01348Presseportal (Swiss press portal, in German)АрхивираноTheDay.com 5/10/2010уу

Допамински агонистиСеротонински антагонистиОрфан лековиУреје


INNserotoninskiantagonisthiperprolaktinemije5-HT2B5-HT2Aserotoninskih receptoraSerotonin2008orfanski lekpulmonarne arterijske hipertenzije2010Pfizer










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Tergurid




Из Википедије, слободне енциклопедије






Иди на навигацију
Иди на претрагу

























Tergurid
Terguride.png

IUPAC ime

N,N-dietil-N'-[(8α)-6-metilergolin-8-il]ureja
Klinički podaci
Drugs.comInternacionalno ime leka
Način primeneOralno
Pravni status
Pravni status

  • ℞ (Prescription only)

Identifikatori
CAS broj
37686-84-3 ДаY
ATC kod
G02CB06 (WHO)
PubChemCID 443951
IUPHAR/BPS56
UNII
21OJT43Q88 ДаY
KEGG
D01348 ДаY
Hemijski podaci
Formula
C20H28N4O
Molarna masa340,46 g/mol



Tergurid (INN) je serotoninski antagonist. On se koristi za lečenje hiperprolaktinemije. Tergurid je oralni, potentni antagonist 5-HT2B i 5-HT2A serotoninskih receptora. Serotonin stimuliše proliferaciju glatkih mišićnih ćelija plućnih arterija, i indukuje fibrozu u zidu plućnih arterija. Ova dva efekta zajedno uzrokuju vaskularno remodelovanje i sužavanje plućnih arterija. Te promene dovode do povećanog vaskularnog otpora i PAH-a. Usled moguće antiproliferativne i antifibrotičke aktivnosti tergurida, ovaj potencijalni lek nalazi primenu u tretmanu vakularnog remodelovanja plućnih arterija i usporavanju progresa bolesti.


Maja 2008, tergurid je odobren kao orfanski lek za tretman pulmonarne arterijske hipertenzije.[1]
Maja 2010 Pfizer je kupio globalna prava na ovaj lek.[2]



Reference




  1. ^ Presseportal (Swiss press portal, in German) Архивирано на сајту Wayback Machine (фебруар 13, 2012) (на језику: енглески)


  2. ^ TheDay.com 5/10/2010



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