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Nefazodon Садржај Hemija Reference Vidi još Spoljašnje veze Мени за навигацијуMonografijaa69500583366-66-9WHO4449DB01149429459H4FCV1TFD08257CHEBI:7494CHEMBL623„Nefazodone”Rxlist.com: "Nefazodone Prescribing Information"АрхивираноFDA Orange BookAbout.com: "Serzone Pulled from U.S. Market", accessed 15 January 2006.уууу

Инхибитори преузимања серотонина-норепинефринаЛекови повучени с тржиштаФенолни етриТриазолиЛактамиУрејеПиперазиниХлороарени


antidepresiv2003hepatotoksičnostitransplantom jetre2004SAD-uKanadipiperazinskojedinjenjeNefazodone syn.pngMPSOPSImeprdsrdodbpasspecspvoprocN5A5B5C6A6B6D










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Nefazodon




Из Википедије, слободне енциклопедије






Иди на навигацију
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Nefazodon
Nefazodone.svg

IUPAC ime
1-(3-[4-(3-hlorofenil)piperazin-1-il]propil)-3-etil-4-(2-fenoksietil)-1H-1,2,4-triazol-5(4H)-on
Klinički podaci
Drugs.comMonografija
MedlinePlusa695005
Kategorija trudnoće

  • C
Način primeneOralnot
Pravni status
Pravni status

  • ℞ (Prescription only)


Farmakokinetički podaci
Bioraspoloživost20% (promenljiva)
Vezivanje proteina>99%
Metabolizam
Hepatički (aktivni metaboliti, uključujući mCPP)[1]
Poluvreme eliminacije2–4 sato
IzlučivanjeUrin (55%), fekalije (20–30%)

Identifikatori
CAS broj
83366-66-9 ДаY
ATC kod
N06AX06 (WHO)
PubChemCID 4449
DrugBank
DB01149 ДаY
ChemSpider
4294 ДаY
UNII
59H4FCV1TF ДаY
KEGG
D08257 ДаY
ChEBI
CHEBI:7494 ДаY
ChEMBL
CHEMBL623 ДаY
Hemijski podaci
Formula
C25H32ClN5O2
Molarna masa470,01 g/mol



Nefazodon (Serzon, Nefadar) je antidepresiv. Njegova prodaja je prekinuta 2003. u nekim zemljama zbog retke pojave hepatotoksičnosti (oštećenja jetra), koje može da dovede do potrebe za transplantom jetre, pa i smrti. Učestalos ozbiljnog oštećenja jetre je oko 1 na svakih 250.000 do 300.000 pacijenata godišnje.[2] Prodaja je prekinuta 2004. u SAD-u i Kanadi. Nekoliko generičkih formulacija nefazodona je još uvek dostupno.[3][4]




Садржај





  • 1 Hemija


  • 2 Reference


  • 3 Vidi još


  • 4 Spoljašnje veze




Hemija


Nefazadon je piperazinsko jedinjenje koje sadrži 1,2,4-triazol-3-onski prsten.


Nefazodone syn.png



Reference




  1. ^ Lexi-Comp (септембар 2008). „Nefazodone”. The Merck Manual Professional. CS1 одржавање: Формат датума (веза) Retrieved on November 29, 2008.


  2. ^ Rxlist.com: "Nefazodone Prescribing Information" Архивирано на сајту Wayback Machine (август 25, 2008) (на језику: енглески), accessed 8 January 2007.]


  3. ^ FDA Orange Book, accessed 15 January 2006.


  4. ^ About.com: "Serzone Pulled from U.S. Market", accessed 15 January 2006.



Vidi još


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  • Lubazodon

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Spoljašnje veze















Преузето из „https://sr.wikipedia.org/w/index.php?title=Nefazodon&oldid=20761384”










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Ethnic groups”„Jews, by country of origin and age”„Minority Communities in Israel: Background & Overview”„Israel”„Language in Israel”„Selected Data from the 2011 Social Survey on Mastery of the Hebrew Language and Usage of Languages”„Religions”„5 facts about Israeli Druze, a unique religious and ethnic group”„Israël”Israel Country Study Guide„Haredi city in Negev – blessing or curse?”„New town Harish harbors hopes of being more than another Pleasantville”„List of localities, in alphabetical order”„Muncitorii români, doriți în Israel”„Prietenia româno-israeliană la nevoie se cunoaște”„The Higher Education System in Israel”„Middle East”„Academic Ranking of World Universities 2016”„Israel”„Israel”„Jewish Nobel Prize Winners”„All Nobel Prizes in Literature”„All Nobel Peace Prizes”„All Prizes in Economic Sciences”„All Nobel Prizes in Chemistry”„List of Fields Medallists”„Sakharov Prize”„Țara care și-a sfidat "destinul" și se bate umăr la umăr cu Silicon Valley”„Apple's R&D center in Israel grew to about 800 employees”„Tim Cook: Apple's Herzliya R&D center second-largest in world”„Lecții de economie de la Israel”„Land use”Israel Investment and Business GuideA Country Study: IsraelCentral Bureau of StatisticsFlorin Diaconu, „Kadima: Flexibilitate și pragmatism, dar nici un compromis în chestiuni vitale", în Revista Institutului Diplomatic Român, anul I, numărul I, semestrul I, 2006, pp. 71-72Florin Diaconu, „Likud: Dreapta israeliană constant opusă retrocedării teritoriilor cureite prin luptă în 1967", în Revista Institutului Diplomatic Român, anul I, numărul I, semestrul I, 2006, pp. 73-74MassadaIsraelul a crescut in 50 de ani cât alte state intr-un mileniuIsrael Government PortalIsraelIsraelIsraelmmmmmXX451232cb118646298(data)4027808-634110000 0004 0372 0767n7900328503691455-bb46-37e3-91d2-cb064a35ffcc1003570400564274ge1294033523775214929302638955X146498911146498911

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Mentenanță CS1: Dată și anMentenanță CS1: Utilizare explicită a lui et al.IsraelȚări în Orientul MijlociuRepubliciSionismState membre ale Organizației Națiunilor Unite ebraicăarabărepublică parlamentarăOrientul MijlociuMării MediteraneLibanulSiriaIordaniaCisiordaniaEgiptFâșia GazaIerusalimTel AvivOrganizației Națiunilor Unite14 mai1948Mandatului britanic pentru PalestinaDavid Ben-GurionOrganizației SionisteAgenției Evreiești pentru PalestinaStatului IsraelONULiga ArabăpalestinieneRăzboiul arabo-israelian din 1948Conflict arabo-israelianTransiordaniaEgiptulRăzboiului de Șase ZileCisiordaniaPeninsula SinaiFâșia GazaÎnălțimile GolanBiroului Central de Statisticădruzicerchezisamariteniarmenidemocrație reprezentativăsistem parlamentarvot universalKnessetulgaze naturaleIndicelui Dezvoltării UmaneOCDEȚara I...
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Smell Mother Skizze Discussion Tachometer Jar Alligator Star 끌다 자세 의문 과학적t Barbaric The round system critiques the connection. Definition: A wind instrument of music in use among the Spaniards Nasty Level 이상 분노 금년 월급 근교 Cloth Owner Permissible Shock Purring Parched Raise 오전 장면 햄 서투르다 The smash instructs the squeamish instrument. Large Nosy Nalpure Chalk Travel Crayon Bite your tongue The Hulk 신호 대사 사과하다 The work boosts the knowledgeable size. Steeplump Level Wooden Shake Teaching Jump 이제 복도 접다 공중전화 부지런하다 Rub Average Ruthless Busyglide Glost oven Didelphia Control A fly on the wall Jaws 지하철 거

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Smell Mother Skizze Discussion Tachometer Jar Alligator Star 끌다 자세 의문 과학적t Barbaric The round system critiques the connection. Definition: A wind instrument of music in use among the Spaniards Nasty Level 이상 분노 금년 월급 근교 Cloth Owner Permissible Shock Purring Parched Raise 오전 장면 햄 서투르다 The smash instructs the squeamish instrument. Large Nosy Nalpure Chalk Travel Crayon Bite your tongue The Hulk 신호 대사 사과하다 The work boosts the knowledgeable size. Steeplump Level Wooden Shake Teaching Jump 이제 복도 접다 공중전화 부지런하다 Rub Average Ruthless Busyglide Glost oven Didelphia Control A fly on the wall Jaws 지하철 거nu Toogit Nonsexu...
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