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Nefazodon Садржај Hemija Reference Vidi još Spoljašnje veze Мени за навигацијуMonografijaa69500583366-66-9WHO4449DB01149429459H4FCV1TFD08257CHEBI:7494CHEMBL623„Nefazodone”Rxlist.com: "Nefazodone Prescribing Information"АрхивираноFDA Orange BookAbout.com: "Serzone Pulled from U.S. Market", accessed 15 January 2006.уууу

Инхибитори преузимања серотонина-норепинефринаЛекови повучени с тржиштаФенолни етриТриазолиЛактамиУрејеПиперазиниХлороарени


antidepresiv2003hepatotoksičnostitransplantom jetre2004SAD-uKanadipiperazinskojedinjenjeNefazodone syn.pngMPSOPSImeprdsrdodbpasspecspvoprocN5A5B5C6A6B6D










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Nefazodon




Из Википедије, слободне енциклопедије






Иди на навигацију
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Nefazodon
Nefazodone.svg

IUPAC ime
1-(3-[4-(3-hlorofenil)piperazin-1-il]propil)-3-etil-4-(2-fenoksietil)-1H-1,2,4-triazol-5(4H)-on
Klinički podaci
Drugs.comMonografija
MedlinePlusa695005
Kategorija trudnoće

  • C
Način primeneOralnot
Pravni status
Pravni status

  • ℞ (Prescription only)


Farmakokinetički podaci
Bioraspoloživost20% (promenljiva)
Vezivanje proteina>99%
Metabolizam
Hepatički (aktivni metaboliti, uključujući mCPP)[1]
Poluvreme eliminacije2–4 sato
IzlučivanjeUrin (55%), fekalije (20–30%)

Identifikatori
CAS broj
83366-66-9 ДаY
ATC kod
N06AX06 (WHO)
PubChemCID 4449
DrugBank
DB01149 ДаY
ChemSpider
4294 ДаY
UNII
59H4FCV1TF ДаY
KEGG
D08257 ДаY
ChEBI
CHEBI:7494 ДаY
ChEMBL
CHEMBL623 ДаY
Hemijski podaci
Formula
C25H32ClN5O2
Molarna masa470,01 g/mol



Nefazodon (Serzon, Nefadar) je antidepresiv. Njegova prodaja je prekinuta 2003. u nekim zemljama zbog retke pojave hepatotoksičnosti (oštećenja jetra), koje može da dovede do potrebe za transplantom jetre, pa i smrti. Učestalos ozbiljnog oštećenja jetre je oko 1 na svakih 250.000 do 300.000 pacijenata godišnje.[2] Prodaja je prekinuta 2004. u SAD-u i Kanadi. Nekoliko generičkih formulacija nefazodona je još uvek dostupno.[3][4]




Садржај





  • 1 Hemija


  • 2 Reference


  • 3 Vidi još


  • 4 Spoljašnje veze




Hemija


Nefazadon je piperazinsko jedinjenje koje sadrži 1,2,4-triazol-3-onski prsten.


Nefazodone syn.png



Reference




  1. ^ Lexi-Comp (септембар 2008). „Nefazodone”. The Merck Manual Professional. CS1 одржавање: Формат датума (веза) Retrieved on November 29, 2008.


  2. ^ Rxlist.com: "Nefazodone Prescribing Information" Архивирано на сајту Wayback Machine (август 25, 2008) (на језику: енглески), accessed 8 January 2007.]


  3. ^ FDA Orange Book, accessed 15 January 2006.


  4. ^ About.com: "Serzone Pulled from U.S. Market", accessed 15 January 2006.



Vidi još


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Spoljašnje veze















Преузето из „https://sr.wikipedia.org/w/index.php?title=Nefazodon&oldid=20761384”










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