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Fananserin Reference Spoljašnje veze Мени за навигацију127625-29-06078538QJ762ET6D02656уу

Допамински антагонистиАнтипсихотициОрганофлуоридиПиперазиниНафталиниИзотиазоли


antagonist5HT2AreceptoruDopaminskom D4 receptorusedativnoantipsihotičnošizofrenije










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Fananserin




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Fananserin
Fananserin.svg

IUPAC ime
2-(3-(4-(p-Fluorofenil)-1-piperazinil)propil)-2H-naft(1,8-cd)izotiazol 1,1-dioksid
Identifikatori
CAS broj
127625-29-0 ДаY
ATC kodnone
PubChemCID 60785
UNII
38QJ762ET6 ДаY
KEGG
D02656 ДаY
SinonimiFananserin
Hemijski podaci
Formula
C23H24FN3O2S
Molarna masa425,519 g/mol



Fananserin (RP-62204) je leki koji deluje kao potentan antagonist na 5HT2A receptoru,[1] i Dopaminskom D4 receptoru,[2] a ne blokira druge dopaminske receptore kao što je D2.[3] On ima sedativno[4] i antipsihotično dejstvo, te je istraživan za moguću primenu u lečenju šizofrenije.[5] Nije se pokazao dovoljno efektivnim, i rezultati su bili nezadovoljavajući.[6]



Reference




  1. ^ Malleron JL, Comte MT, Gueremy C, Peyronel JF, Truchon A, Blanchard JC, Doble A, Piot O, Zundel JL, Huon C, et al. Naphthosultam derivatives: a new class of potent and selective 5-HT2 antagonists. Journal of Medicinal Chemistry. 1991 Aug;34(8):2477-83. PMID 1908521


  2. ^ Heuillet E, Petitet F, Mignani S, Malleron JL, Lavayre J, Néliat G, Doble A, Blanchard JC. The naphtosultam derivative RP 62203 (fananserin) has high affinity for the dopamine D4 receptor. European Journal of Pharmacology. 1996 Oct 24;314(1-2):229-33. PMID 8957240


  3. ^ Doble A, Girdlestone D, Piot O, Allam D, Betschart J, Boireau A, Dupuy A, Guérémy C, Ménager J, Zundel JL, et al. Pharmacological characterization of RP 62203, a novel 5-hydroxytryptamine 5-HT2 receptor antagonist. British Journal of Pharmacology. 1992 Jan;105(1):27-36. PMID 1596688


  4. ^ Stutzmann JM, Eon B, Lucas M, Blanchard JC, Laduron PM. RP 62203, a 5-hydroxytryptamine2 antagonist, enhances deep NREM sleep in rats. Sleep. 1992 Apr;15(2):119-24. PMID 1579785


  5. ^ Sramek JJ, Kirkesseli S, Paccaly-Moulin A, Davidson J, Jhee SS, Hourani J, Sémiond D, Cutler NR. A bridging study of fananserin in schizophrenic patients. Psychopharmacology Bulletin. 1998;34(4):811-8. PMID 10513457


  6. ^ Truffinet P, Tamminga CA, Fabre LF, Meltzer HY, Rivière ME, Papillon-Downey C. Placebo-controlled study of the D4/5-HT2A antagonist fananserin in the treatment of schizophrenia. American Journal of Psychiatry. 1999 Mar;156(3):419-25. PMID 10080558



Spoljašnje veze













Преузето из „https://sr.wikipedia.org/w/index.php?title=Fananserin&oldid=12331387”










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Ethnic groups”„Jews, by country of origin and age”„Minority Communities in Israel: Background & Overview”„Israel”„Language in Israel”„Selected Data from the 2011 Social Survey on Mastery of the Hebrew Language and Usage of Languages”„Religions”„5 facts about Israeli Druze, a unique religious and ethnic group”„Israël”Israel Country Study Guide„Haredi city in Negev – blessing or curse?”„New town Harish harbors hopes of being more than another Pleasantville”„List of localities, in alphabetical order”„Muncitorii români, doriți în Israel”„Prietenia româno-israeliană la nevoie se cunoaște”„The Higher Education System in Israel”„Middle East”„Academic Ranking of World Universities 2016”„Israel”„Israel”„Jewish Nobel Prize Winners”„All Nobel Prizes in Literature”„All Nobel Peace Prizes”„All Prizes in Economic Sciences”„All Nobel Prizes in Chemistry”„List of Fields Medallists”„Sakharov Prize”„Țara care și-a sfidat "destinul" și se bate umăr la umăr cu Silicon Valley”„Apple's R&D center in Israel grew to about 800 employees”„Tim Cook: Apple's Herzliya R&D center second-largest in world”„Lecții de economie de la Israel”„Land use”Israel Investment and Business GuideA Country Study: IsraelCentral Bureau of StatisticsFlorin Diaconu, „Kadima: Flexibilitate și pragmatism, dar nici un compromis în chestiuni vitale", în Revista Institutului Diplomatic Român, anul I, numărul I, semestrul I, 2006, pp. 71-72Florin Diaconu, „Likud: Dreapta israeliană constant opusă retrocedării teritoriilor cureite prin luptă în 1967", în Revista Institutului Diplomatic Român, anul I, numărul I, semestrul I, 2006, pp. 73-74MassadaIsraelul a crescut in 50 de ani cât alte state intr-un mileniuIsrael Government PortalIsraelIsraelIsraelmmmmmXX451232cb118646298(data)4027808-634110000 0004 0372 0767n7900328503691455-bb46-37e3-91d2-cb064a35ffcc1003570400564274ge1294033523775214929302638955X146498911146498911

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Mentenanță CS1: Dată și anMentenanță CS1: Utilizare explicită a lui et al.IsraelȚări în Orientul MijlociuRepubliciSionismState membre ale Organizației Națiunilor Unite ebraicăarabărepublică parlamentarăOrientul MijlociuMării MediteraneLibanulSiriaIordaniaCisiordaniaEgiptFâșia GazaIerusalimTel AvivOrganizației Națiunilor Unite14 mai1948Mandatului britanic pentru PalestinaDavid Ben-GurionOrganizației SionisteAgenției Evreiești pentru PalestinaStatului IsraelONULiga ArabăpalestinieneRăzboiul arabo-israelian din 1948Conflict arabo-israelianTransiordaniaEgiptulRăzboiului de Șase ZileCisiordaniaPeninsula SinaiFâșia GazaÎnălțimile GolanBiroului Central de Statisticădruzicerchezisamariteniarmenidemocrație reprezentativăsistem parlamentarvot universalKnessetulgaze naturaleIndicelui Dezvoltării UmaneOCDEȚara I...
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Кастелфранко ди Сопра Становништво Референце Спољашње везе Мени за навигацију43°37′18″ СГШ; 11°33′32″ ИГД / 43.62156° СГШ; 11.55885° ИГД / 43.62156; 11.5588543°37′18″ СГШ; 11°33′32″ ИГД / 43.62156° СГШ; 11.55885° ИГД / 43.62156; 11.558853179688„The GeoNames geographical database”„Istituto Nazionale di Statistica”проширитиууWorldCat156923403n850174324558639-1cb14643287r(подаци)

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Acquaborra-CaselleAdattiAlbergoAlberoroAmbraAnatraiaAnciolinaAnghiariAntriaAppaltoArea ProduttivaArezzoArsicciAvenaBaccanelloBadia A RuotiBadia AgnanoBadia PratagliaBadia TedaldaBadia TegaBadia al PinoBadicorteBadiola IBadiola IIBagnaiaBagnolo IBagnolo IIBanzenaBarbianoBarullo-CentoiaBatelliBattifolle-Ruscello-PoggiolaBattifolloBecarinoBeglianoBellavistaBellosguardoBertineBibbianoBibbienaBiccianoBiforcoBigurroBorgaccianoBorghettoBorgo alla CollinaBorgonuovoBorroBossi-CellaioBottegaBrancialinoBucineBugianaBuianoBulcianoBuon RiposoButaleCafaggioCaianoCalbuffaCalcinaiaCallagnoloCalletaCalucacciaCamaldoliCampaccioCampiCampogialliCampoleoneCampolombardoCampoluciCamprenaCamucia-MonsiglioloCapannoleCapezziCapolonaCaposelviCappella BrocchiCappuccini di MontautoCappucciniCapraiaCaprese MichelangeloCaprileCardaCardeta di SopraCarmineCasa BiondoCasa CaroniCasa MarcoCasa MugnainiCasa Vanni - le SelveCasa al CincioCasa alla SisaCasa del ReCasa le BizzeCasacciola-BelvedereCasal GoriCasaleCasalecchio...
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