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Droperidol Садржај Hemija Reference Literatura Spoljašnje veze Мени за навигацију548-73-2WHO3168DB00450O9U0F09D5XD00308CHEMBL11082105968218048412GB 989755BE 626307U.S. Patent 3.141.823U.S. Patent 3.161.645уууууу

АнтиеметициЛактамиОрганофлуоридиУрејеБензимидазолиТетрахидропиридиниБутирофенонски антипсихотици


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Droperidol




Из Википедије, слободне енциклопедије






Иди на навигацију
Иди на претрагу


Ne poistovećivati sa dronabinolom ili domperidonom.






























Droperidol
Skeletal formula of droperidol
Droperidol-3D-spacefill.png

IUPAC ime
1-1-[4-(4-fluorofenil)-4-oksobutil]-1,2,5,6-tetrahidropiridin-4-il-1,3-dihidro-2H-benzimidazol-2-on
Klinički podaci
Kategorija trudnoće

  • C (SAD)
Način primeneIntravenozno, Intramaskularno
Pravni status
Pravni status


  • US: ℞-only


Farmakokinetički podaci
MetabolizamHepatički
Poluvreme eliminacije2,3 sata

Identifikatori
CAS broj548-73-2
ATC kod
N05AD08 (WHO)
PubChemCID 3168
DrugBankDB00450
UNII
O9U0F09D5X ДаY
KEGGD00308
ChEMBL
CHEMBL1108 ДаY
Hemijski podaci
Formula
C22H22FN3O2
Molarna masa379,428 g/mol



Droperidol (Inapsine, Droleptan, Dridol, Xomolix, Innovar [kombinacija sa fentanilom]) je antidopaminergički lek koji se koristi kao antiemetik i antipsihotik.[1][2] Droperidol se takođe koristi za neuroleptanalgezijsku anesteziju i sedaciju pri intenzivnoj nezi.




Садржај





  • 1 Hemija


  • 2 Reference


  • 3 Literatura


  • 4 Spoljašnje veze




Hemija


Droperidol se može sintetisati iz 1-benzil-3-karbetoksipiperidin-4-ona, reakcijom sa o-fenilendiaminom.[3][4][5][6]


Droperidol synth.png


Reference




  1. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMID 21059682. 


  2. ^ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (Nucleic Acids Res) (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. 36 (Database issue): D901—6. PMID 18048412. CS1 одржавање: Вишеструка имена: списак аутора (веза)


  3. ^ C. Janssen, NV Res. Lab., GB 989755  (1962).


  4. ^ Janssen, P. A. J.; 1963, Belgian Patent BE 626307 .


  5. ^ F.J. Gardocki, J. Janssen, U.S. Patent 3.141.823 (1964).


  6. ^ P.A.J. Janssen, U.S. Patent 3.161.645 (1964).



Literatura


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  • Scuderi PE: Droperidol: Many questions, few answers. Anesthesiology 2003; 98: 289-90

  • Lischke V, Behne M, Doelken P, Schledt U, Probst S, Vettermann J. Droperidol causes a dose-dependent prolongation of the QT interval. Department of Anesthesiology and Resuscitation, Johann Wolfgang Goethe-University Clinics, Frankfurt am Main, Germany.

  • Emergency Medicine Magazine : https://web.archive.org/web/20110527190715/http://www.emedmag.com/html/pre/tri/1005.asp



Spoljašnje veze











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u vezi sa temama iz oblasti medicine (zdravlja).






Преузето из „https://sr.wikipedia.org/w/index.php?title=Droperidol&oldid=20743792”










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