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Trifluoperazin Садржај Farmakologija Hemija Reference Spoljašnje veze Мени за навигацијуMonografijaa682121117-89-5WHO5566214DB008315365214IZI85K3CHEBI:45951 CHEMBL422„Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects”61351461976Natur.261..717S94546710.1038/261717a09081563„Trifluoperazine Hydrochloride”CRC desk reference of clinical pharmacology10.1021/jo01357a618U.S. Patent 2.921.069568005410.1021/jm00312a600DE 1165034Trifluoperazine bound to proteinsуууууу

3-PPP4-PPBP5-MeO-DMTAlazocin (SKF-10047)AmantadinANAVEX2-73ArketaminBD-737BD-1052KaptodiamCitalopramCGRPKloperastinKokainKutamezin (SA-4503)CiklazocinDehidroepiandrosteron (DHEA)prasteronDehidroepiandrosteron sulfat (DHEA-S)prasteron sulfatDekstralorfanDekstrometorfan (DXM)Dekstrorfan (DXO)DimemorfanDimetiltriptamin (DMT)Ditolilgvanidin (DTG)DonepezilEliprodilEscitalopramFabomotizol (afobazol)FluoksetinFluvoksaminIfenprodilIgmesin (JO-1784)IPABKetaminL-687384MDMA (midomafetamin)MemantinMetamfetaminMetoksetaminMetilfenidatNepinalonNeuropeptid YNoskapinOPC-14523OpipramolPentazocinPentoksiverin (karbetapentan)PRE-084PregnenolonPregnenolon sulfatPridopidinRacemetorfan (metorfan)Racemorfan (morfanol)UMB-23UMB-823-PPPAC-927BD-1008BD-1031BD-1047BD-1060BD-1063BD-1067BMY-14802 (BMS-181100)CM-156Dup-734E-5842E-52862 (S1RA)HaloperidolLR-132LR-172MS-377NE-100NPC-16377Panamesin (EMD-57455)PD-144418PentazocinProgesteronRimkazol (BW-234U)SertralinSR-31742AFenitoinMetilfenilpiracetamSOMCL-6683-Metoksidekstralorfan3-MeO-PCP4C-T-24-IBP4-IPBS4-MeO-PCP5-MeO-DALT5-MeO-DiPTAmitriptilinAzidopamilHlorpromazinKlemastinKlomipraminKlorgilinD-DeprenilDiPTDPTIbogainImipraminKCR-12-83.1NemonapridNoribogainRHL-033RS-67,333RTI-55ŠafranSafinamidSelegilinSpipetijanTrifluoperazinW-18YKP10ABerberinEtilketazocinForfitMetafitNalbufinNaluzotanTapentadolTenociklidinAHD1AZ66LamotriginNaloksonSM-21UMB-100UMB-101UMB-103UMB-116YZ-011YZ-069YZ-185SKF-8395918-MetoksikoronaridinBMY-13980ButaklamolKaramifenKarvotrolinHlorfenamin (hlorfeniramin)HlorpromazinCinarizinCinuperonKlocapraminDezocinEMD-59983HipericinkantarionFlufenazinGevotrolin (WY-47384)Mepiramin (pirilamin)MolindonPerfenazinPimozidProadifenPrometazinPropranololHinidinRemoksipridSL 82.0715SR-31747ATiospiron (BMY-13859)Venlafaksin


ФенотиазиниПиперазиниОрганофлуориди


tipični antipsihotikfenotiazinskehemijske klasesimpatolitikantagonist dopaminskog receptoraantiholinergičnimprohlorperazinAzaperonBenperidolBromperidolDroperidolFluanizonHaloperidolLenperonMoperonPipamperonSpiperonTimiperonTrifluperidolKlopimozidFluspirilenPenfluridolPimozidAcepromazinAcetofenazinButaperazinKarfenazinHloracizinHlorproetazinHlorpromazinCijamemazinDiksirazinFluacizinFlufenazinLevomepromazin/MetotrimeprazinMezoridazinPerazinPericijazinPerfenazinPiperacetazinPipotiazinProhlorperazinPromazinPrometazinPropiomazinSulforidazinTietilperazinTiopropazatTioproperazinTioridazinTrifluoperazinTriflupromazinHlorprotiksenKlopentiksolFlupentiksolTiotiksenZuklopentiksolButaklamolFluotracenLoksapinTrimipraminCinuperonMelperonSetoperonIloperidonOkaperidonPaliperidonRisperidonLurasidonePerospironRevospironTiospironZiprasidonAmperozidAripiprazolBifeprunoksBrekspiprazolElopiprazolUmespironAmoksapinAsenapinKarpipraminKlocapraminKlorotepinKlotiapinKlozapinFluperlapinGevotrolinMetitepinMosapraminNDMCOlanzapinPihindonKvetijapinTenilapinZotepinWHO-EMPovučeniKlinička ispitivanjaFaza IIINije dospeo do faze IIIMPSOPSImeprdsrdodbpasspecspvoprocN5A5B5C6A6B6DAkrivastinAlinastinAstemizolAzelastinBamirastinBarmastinBepiastinBepotastinBilastinKabastinenKarebastinKetirizinKlemastinKlemizolKlobenztropinDorastinEbastinEmedastinEpinastinFlezelastinKetotifenLatrepirdinLevokabastinLinetastinLoratadinMapinastinMebhidrolinMizolastinMoksastinNoberastinOktastinOlopatadinPerastinPiklopastinRokastinRupatadinSetastinTalastinTemelastinTerfenadinZepastinDesloratadinFeksofenadinCetirizin‎‎LevocetirizinBelarizinEfletirizinElbanizinFlotrenizinMedrilaminNapaktadinPibaksizinTagorizinTrelnarizinTrenizinVapitadin










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Trifluoperazin




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Trifluoperazin (Eskazinil, Eskazin, Jatroneural, Modalina, Stelazin, Terfluzin, Trifluoperaz, Triftazin) je tipični antipsihotik iz fenotiazinske hemijske klase.




Садржај





  • 1 Farmakologija


  • 2 Hemija


  • 3 Reference


  • 4 Spoljašnje veze




Farmakologija


Trifluoperazin je centralni simpatolitik,[1]antagonist dopaminskog receptora,[2][3] sa minimalnim antiholinergičnim dejstvom.[4]



Hemija


Trifluoperazin (2-trifluorometil-10-[3-(4-metil-1-piperazinil)propil]fenotazin) se sintetiše na sličan način kao i prohlorperazin. Alkilacija se izvodi koristeći 2-trifluorometilfenotazin-4-metil-1-piperazinilpropilhlorid kao supstrat.[5][6][7][8][9]



Reference




  1. ^ Huerta-Bahena J, Villalobos-Molina R, García-Sáinz JA (1983). „Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects”. Molecular Pharmacology. 23 (1): 67—70. PMID 6135146. Приступљено 21. 6. 2009. 


  2. ^ Seeman P, Lee T, Chau-Wong M, Wong K (1976). „Antipsychotic drug doses and neuroleptic/dopamine receptors”. Nature. 261 (5562): 717—9. Bibcode:1976Natur.261..717S. PMID 945467. doi:10.1038/261717a0. 


  3. ^ Creese I, Burt DR, Snyder SH (1996). „Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs”. The Journal of Neuropsychiatry and Clinical Neurosciences. 8 (2): 223—6. PMID 9081563.  |access-date= захтева |url= (помоћ)


  4. ^ Ebadi, Manuchair S (1998). „Trifluoperazine Hydrochloride”. CRC desk reference of clinical pharmacology (illustrated изд.). CRC Press. ISBN 978-0-8493-9683-0. Приступљено 21. 6. 2009. 


  5. ^ Craig, P.; Nodiff, E.; Lafferty, J.; Ullyot, G. (1957). „Notes - New Trifluoromethylphenothiazine Derivatives”. Journal of Organic Chemistry. 22 (6): 709. doi:10.1021/jo01357a618. 


  6. ^ G.E. Ullyot, U.S. Patent 2.921.069 (1960).


  7. ^ Sharma, H.; Banerjee, S.; Sharma, V.; Mital, R. (1968). „Phenothiazines Exhibiting Lesser Extraparamidal Manifestations”. Journal of Medicinal Chemistry. 11 (6): 1244. PMID 5680054. doi:10.1021/jm00312a600. 


  8. ^ P.N. Craig, G.E. Ullyot, DE 1165034  (1956).


  9. ^ B.H. Chung, F. Zimalkowski, Arch. Pharm., 317, 323 (1984).



Spoljašnje veze


  • Trifluoperazine bound to proteins
Trifluoperazin
Trifluoperazine.svg

IUPAC ime
10-[3-(4-metilpiperazin-1-il)propil]-
2-(trifluorometil)-10H-fenotiazin
Klinički podaci
Drugs.comMonografija
MedlinePlusa682121
Kategorija trudnoće


  • AU: C


  • US: C (Mogući rizik)


Način primeneoralno, IM
Pravni status
Pravni status


  • UK: POM (Samo na recepat)


  • US: ℞-only



Farmakokinetički podaci
MetabolizamHepatički
Poluvreme eliminacije10–20 sata
Izlučivanje

Identifikatori
CAS broj
117-89-5 ДаY
ATC kod
N05AB06 (WHO)
PubChemCID 5566
IUPHAR/BPS214
DrugBank
DB00831 ДаY
ChemSpider
5365 ДаY
UNII
214IZI85K3 ДаY
ChEBI
CHEBI:45951 ДаY
ChEMBL

CHEMBL422
 ДаY
Hemijski podaci
Formula
C21H24F3N3S
Molarna masa407,497





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Mentenanță CS1: Dată și anMentenanță CS1: Utilizare explicită a lui et al.IsraelȚări în Orientul MijlociuRepubliciSionismState membre ale Organizației Națiunilor Unite ebraicăarabărepublică parlamentarăOrientul MijlociuMării MediteraneLibanulSiriaIordaniaCisiordaniaEgiptFâșia GazaIerusalimTel AvivOrganizației Națiunilor Unite14 mai1948Mandatului britanic pentru PalestinaDavid Ben-GurionOrganizației SionisteAgenției Evreiești pentru PalestinaStatului IsraelONULiga ArabăpalestinieneRăzboiul arabo-israelian din 1948Conflict arabo-israelianTransiordaniaEgiptulRăzboiului de Șase ZileCisiordaniaPeninsula SinaiFâșia GazaÎnălțimile GolanBiroului Central de Statisticădruzicerchezisamariteniarmenidemocrație reprezentativăsistem parlamentarvot universalKnessetulgaze naturaleIndicelui Dezvoltării UmaneOCDEȚara I...
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Smell Mother Skizze Discussion Tachometer Jar Alligator Star 끌다 자세 의문 과학적t Barbaric The round system critiques the connection. Definition: A wind instrument of music in use among the Spaniards Nasty Level 이상 분노 금년 월급 근교 Cloth Owner Permissible Shock Purring Parched Raise 오전 장면 햄 서투르다 The smash instructs the squeamish instrument. Large Nosy Nalpure Chalk Travel Crayon Bite your tongue The Hulk 신호 대사 사과하다 The work boosts the knowledgeable size. Steeplump Level Wooden Shake Teaching Jump 이제 복도 접다 공중전화 부지런하다 Rub Average Ruthless Busyglide Glost oven Didelphia Control A fly on the wall Jaws 지하철 거

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Smell Mother Skizze Discussion Tachometer Jar Alligator Star 끌다 자세 의문 과학적t Barbaric The round system critiques the connection. Definition: A wind instrument of music in use among the Spaniards Nasty Level 이상 분노 금년 월급 근교 Cloth Owner Permissible Shock Purring Parched Raise 오전 장면 햄 서투르다 The smash instructs the squeamish instrument. Large Nosy Nalpure Chalk Travel Crayon Bite your tongue The Hulk 신호 대사 사과하다 The work boosts the knowledgeable size. Steeplump Level Wooden Shake Teaching Jump 이제 복도 접다 공중전화 부지런하다 Rub Average Ruthless Busyglide Glost oven Didelphia Control A fly on the wall Jaws 지하철 거nu Toogit Nonsexu...
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