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Trifluoperazin Садржај Farmakologija Hemija Reference Spoljašnje veze Мени за навигацијуMonografijaa682121117-89-5WHO5566214DB008315365214IZI85K3CHEBI:45951 CHEMBL422„Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects”61351461976Natur.261..717S94546710.1038/261717a09081563„Trifluoperazine Hydrochloride”CRC desk reference of clinical pharmacology10.1021/jo01357a618U.S. Patent 2.921.069568005410.1021/jm00312a600DE 1165034Trifluoperazine bound to proteinsуууууу

3-PPP4-PPBP5-MeO-DMTAlazocin (SKF-10047)AmantadinANAVEX2-73ArketaminBD-737BD-1052KaptodiamCitalopramCGRPKloperastinKokainKutamezin (SA-4503)CiklazocinDehidroepiandrosteron (DHEA)prasteronDehidroepiandrosteron sulfat (DHEA-S)prasteron sulfatDekstralorfanDekstrometorfan (DXM)Dekstrorfan (DXO)DimemorfanDimetiltriptamin (DMT)Ditolilgvanidin (DTG)DonepezilEliprodilEscitalopramFabomotizol (afobazol)FluoksetinFluvoksaminIfenprodilIgmesin (JO-1784)IPABKetaminL-687384MDMA (midomafetamin)MemantinMetamfetaminMetoksetaminMetilfenidatNepinalonNeuropeptid YNoskapinOPC-14523OpipramolPentazocinPentoksiverin (karbetapentan)PRE-084PregnenolonPregnenolon sulfatPridopidinRacemetorfan (metorfan)Racemorfan (morfanol)UMB-23UMB-823-PPPAC-927BD-1008BD-1031BD-1047BD-1060BD-1063BD-1067BMY-14802 (BMS-181100)CM-156Dup-734E-5842E-52862 (S1RA)HaloperidolLR-132LR-172MS-377NE-100NPC-16377Panamesin (EMD-57455)PD-144418PentazocinProgesteronRimkazol (BW-234U)SertralinSR-31742AFenitoinMetilfenilpiracetamSOMCL-6683-Metoksidekstralorfan3-MeO-PCP4C-T-24-IBP4-IPBS4-MeO-PCP5-MeO-DALT5-MeO-DiPTAmitriptilinAzidopamilHlorpromazinKlemastinKlomipraminKlorgilinD-DeprenilDiPTDPTIbogainImipraminKCR-12-83.1NemonapridNoribogainRHL-033RS-67,333RTI-55ŠafranSafinamidSelegilinSpipetijanTrifluoperazinW-18YKP10ABerberinEtilketazocinForfitMetafitNalbufinNaluzotanTapentadolTenociklidinAHD1AZ66LamotriginNaloksonSM-21UMB-100UMB-101UMB-103UMB-116YZ-011YZ-069YZ-185SKF-8395918-MetoksikoronaridinBMY-13980ButaklamolKaramifenKarvotrolinHlorfenamin (hlorfeniramin)HlorpromazinCinarizinCinuperonKlocapraminDezocinEMD-59983HipericinkantarionFlufenazinGevotrolin (WY-47384)Mepiramin (pirilamin)MolindonPerfenazinPimozidProadifenPrometazinPropranololHinidinRemoksipridSL 82.0715SR-31747ATiospiron (BMY-13859)Venlafaksin


ФенотиазиниПиперазиниОрганофлуориди


tipični antipsihotikfenotiazinskehemijske klasesimpatolitikantagonist dopaminskog receptoraantiholinergičnimprohlorperazinAzaperonBenperidolBromperidolDroperidolFluanizonHaloperidolLenperonMoperonPipamperonSpiperonTimiperonTrifluperidolKlopimozidFluspirilenPenfluridolPimozidAcepromazinAcetofenazinButaperazinKarfenazinHloracizinHlorproetazinHlorpromazinCijamemazinDiksirazinFluacizinFlufenazinLevomepromazin/MetotrimeprazinMezoridazinPerazinPericijazinPerfenazinPiperacetazinPipotiazinProhlorperazinPromazinPrometazinPropiomazinSulforidazinTietilperazinTiopropazatTioproperazinTioridazinTrifluoperazinTriflupromazinHlorprotiksenKlopentiksolFlupentiksolTiotiksenZuklopentiksolButaklamolFluotracenLoksapinTrimipraminCinuperonMelperonSetoperonIloperidonOkaperidonPaliperidonRisperidonLurasidonePerospironRevospironTiospironZiprasidonAmperozidAripiprazolBifeprunoksBrekspiprazolElopiprazolUmespironAmoksapinAsenapinKarpipraminKlocapraminKlorotepinKlotiapinKlozapinFluperlapinGevotrolinMetitepinMosapraminNDMCOlanzapinPihindonKvetijapinTenilapinZotepinWHO-EMPovučeniKlinička ispitivanjaFaza IIINije dospeo do faze IIIMPSOPSImeprdsrdodbpasspecspvoprocN5A5B5C6A6B6DAkrivastinAlinastinAstemizolAzelastinBamirastinBarmastinBepiastinBepotastinBilastinKabastinenKarebastinKetirizinKlemastinKlemizolKlobenztropinDorastinEbastinEmedastinEpinastinFlezelastinKetotifenLatrepirdinLevokabastinLinetastinLoratadinMapinastinMebhidrolinMizolastinMoksastinNoberastinOktastinOlopatadinPerastinPiklopastinRokastinRupatadinSetastinTalastinTemelastinTerfenadinZepastinDesloratadinFeksofenadinCetirizin‎‎LevocetirizinBelarizinEfletirizinElbanizinFlotrenizinMedrilaminNapaktadinPibaksizinTagorizinTrelnarizinTrenizinVapitadin










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Trifluoperazin




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Trifluoperazin (Eskazinil, Eskazin, Jatroneural, Modalina, Stelazin, Terfluzin, Trifluoperaz, Triftazin) je tipični antipsihotik iz fenotiazinske hemijske klase.




Садржај





  • 1 Farmakologija


  • 2 Hemija


  • 3 Reference


  • 4 Spoljašnje veze




Farmakologija


Trifluoperazin je centralni simpatolitik,[1]antagonist dopaminskog receptora,[2][3] sa minimalnim antiholinergičnim dejstvom.[4]



Hemija


Trifluoperazin (2-trifluorometil-10-[3-(4-metil-1-piperazinil)propil]fenotazin) se sintetiše na sličan način kao i prohlorperazin. Alkilacija se izvodi koristeći 2-trifluorometilfenotazin-4-metil-1-piperazinilpropilhlorid kao supstrat.[5][6][7][8][9]



Reference




  1. ^ Huerta-Bahena J, Villalobos-Molina R, García-Sáinz JA (1983). „Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects”. Molecular Pharmacology. 23 (1): 67—70. PMID 6135146. Приступљено 21. 6. 2009. 


  2. ^ Seeman P, Lee T, Chau-Wong M, Wong K (1976). „Antipsychotic drug doses and neuroleptic/dopamine receptors”. Nature. 261 (5562): 717—9. Bibcode:1976Natur.261..717S. PMID 945467. doi:10.1038/261717a0. 


  3. ^ Creese I, Burt DR, Snyder SH (1996). „Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs”. The Journal of Neuropsychiatry and Clinical Neurosciences. 8 (2): 223—6. PMID 9081563.  |access-date= захтева |url= (помоћ)


  4. ^ Ebadi, Manuchair S (1998). „Trifluoperazine Hydrochloride”. CRC desk reference of clinical pharmacology (illustrated изд.). CRC Press. ISBN 978-0-8493-9683-0. Приступљено 21. 6. 2009. 


  5. ^ Craig, P.; Nodiff, E.; Lafferty, J.; Ullyot, G. (1957). „Notes - New Trifluoromethylphenothiazine Derivatives”. Journal of Organic Chemistry. 22 (6): 709. doi:10.1021/jo01357a618. 


  6. ^ G.E. Ullyot, U.S. Patent 2.921.069 (1960).


  7. ^ Sharma, H.; Banerjee, S.; Sharma, V.; Mital, R. (1968). „Phenothiazines Exhibiting Lesser Extraparamidal Manifestations”. Journal of Medicinal Chemistry. 11 (6): 1244. PMID 5680054. doi:10.1021/jm00312a600. 


  8. ^ P.N. Craig, G.E. Ullyot, DE 1165034  (1956).


  9. ^ B.H. Chung, F. Zimalkowski, Arch. Pharm., 317, 323 (1984).



Spoljašnje veze


  • Trifluoperazine bound to proteins
Trifluoperazin
Trifluoperazine.svg

IUPAC ime
10-[3-(4-metilpiperazin-1-il)propil]-
2-(trifluorometil)-10H-fenotiazin
Klinički podaci
Drugs.comMonografija
MedlinePlusa682121
Kategorija trudnoće


  • AU: C


  • US: C (Mogući rizik)


Način primeneoralno, IM
Pravni status
Pravni status


  • UK: POM (Samo na recepat)


  • US: ℞-only



Farmakokinetički podaci
MetabolizamHepatički
Poluvreme eliminacije10–20 sata
Izlučivanje

Identifikatori
CAS broj
117-89-5 ДаY
ATC kod
N05AB06 (WHO)
PubChemCID 5566
IUPHAR/BPS214
DrugBank
DB00831 ДаY
ChemSpider
5365 ДаY
UNII
214IZI85K3 ДаY
ChEBI
CHEBI:45951 ДаY
ChEMBL

CHEMBL422
 ДаY
Hemijski podaci
Formula
C21H24F3N3S
Molarna masa407,497





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