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RDS-127 Reference Vidi još Spoljašnje veze Мени за навигацију82668-32-4134064„RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane): central effects of a new dopamine receptor agonist”640133471149736145768373772210.1016/0031-9384(86)90382-316853132907277169269710.3109/13813459009115730689728510.1016/0028-3908(82)90080-6287767710.1037/0735-7044.100.5.664у

Допамински агонистиАгонисти серотонинског рецептораИнданиФенолни етри


lekagonistD2 sličnih receptoraserotoninskeadrenergičkeantiholinergičkoanoreksično










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RDS-127




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RDS-127
RDS-127 structure.png

IUPAC ime
4,7-dimetoksi-N,N-dipropil-2,3-dihidro-1H-inden-2-amin
Identifikatori
CAS broj
82668-32-4 ДаY
ATC kodnone
PubChemCID 134064
Hemijski podaci
Formula
C17H27NO2
Molarna masa277,402 g/mol



RDS-127 je lek koji se koristi u naučnim istraživanjima. On deluje kao agonist D2 sličnih receptora,[1] a manifestuje i serotoninske i adrenergičke efekte,[2][3][4][5] kao i antiholinergičko dejstvo.[6][7] U životinjskim studijama on pokazuje anoreksično dejstvo i stimuliše seksualni nagon.[8][9]



Reference




  1. ^ Arnerić SP; Long JP; Williams M; et al. (1983). „RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane): central effects of a new dopamine receptor agonist”. The Journal of Pharmacology and Experimental Therapeutics. 224 (1): 161—70. PMID 6401334. CS1 одржавање: Експлицитна употреба et al. (веза)


  2. ^ Arnerić SP, Roetker A, Long JP, Mott J, Barfknecht CF (1982). „Effects of semirigid methoxamine analogs on vascular smooth muscle: studies of methoxy-2-aminotetralin and 2-aminoindane derivatives”. Archives Internationales De Pharmacodynamie et De Thérapie. 257 (2): 263—73. PMID 7114973. 


  3. ^ Arnerić SP, Long JP (1984). „Evidence that a novel dopamine receptor agonist, RDS-127 [2-di-n-propylamino-4,7-dimethoxyindane] has some centrally mediated cardiovascular actions”. The Journal of Pharmacy and Pharmacology. 36 (5): 318—21. PMID 6145768. 


  4. ^ Clark JT, Smith ER (1986). „Failure of pimozide and metergoline to antagonize the RDS-127-induced facilitation of ejaculatory behavior”. Physiology & Behavior. 37 (1): 47—52. PMID 3737722. doi:10.1016/0031-9384(86)90382-3. 


  5. ^ Rezaki YE, Ilhan M (1991). „Evaluation of alpha-adrenoceptor agonistic activity of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in rabbit and rat aortae”. Archives Internationales De Pharmacodynamie et De Thérapie. 310: 76—86. PMID 1685313. 


  6. ^ Sahin I, Ilhan M (1988). „The antimuscarinic activity of a dopamine receptor agonist (RDS-127) differentiates M2-muscarinic receptors of heart, ileum and trachea in guinea-pig”. Archives Internationales De Pharmacodynamie et De Thérapie. 296: 163—72. PMID 2907277. 


  7. ^ Sahin I, Tuncer M, Ilhan M (1990). „Dopamine receptor agonists, N,N-dipropyl-2-aminotetralin (TL-68) and 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127) antagonize oxotremorine-induced tremors by antimuscarinic action in mice”. Archives Internationales De Physiologie et De Biochimie. 98 (1): 7—9. PMID 1692697. doi:10.3109/13813459009115730. 


  8. ^ Arnerić SP, Roetker A, Long JP (1982). „Potent anorexic-like effects of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in the rat: a comparison with other dopamine-receptor agonists”. Neuropharmacology. 21 (9): 885—90. PMID 6897285. doi:10.1016/0028-3908(82)90080-6. 


  9. ^ Kwong LL, Smith ER, Davidson JM, Peroutka SJ (1986). „Differential interactions of "prosexual" drugs with 5-hydroxytryptamine1A and alpha 2-adrenergic receptors”. Behavioral Neuroscience. 100 (5): 664—8. PMID 2877677. doi:10.1037/0735-7044.100.5.664. 



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