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Ekopipam Hemijska sinteza Reference Spoljašnje veze Мени за навигацију112108-01-71079300X748O646K2905002118996191763609010.1038/oby.2007.20511899619у

ФенолиАзепиниХлороарени


benzazepinskiantagonistD1D5receptorasedativnoantipsihotičkoanoreksnodepresijaanksioznosttetralina










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Ekopipam




Из Википедије, слободне енциклопедије






Иди на навигацију
Иди на претрагу















Ekopipam
Ecopipam structure.png

IUPAC ime
(–)-trans-6,7,7a,8,9,13b-heksahidro-3-hloro-2-hidroksi-N-metil-5H-benzo[d]napto-(2,1-b)azepin
Identifikatori
CAS broj
112108-01-7 ДаY
ATC kodnone
PubChemCID 107930
UNII
0X748O646K ДаY
Hemijski podaci
Formula
C19H20ClNO
Molarna masa313,821 g/mol

Ekopipam (SCH-39166) je sintetički benzazepinski derivat. Ovaj lek deluje kao selektivni antagonist D1/D5 receptora, sa neznatnim afinitetom za bilo D2-slične ili 5-HT2 receptore.[1] On ispoljava sedativno, antipsihotičko i anoreksno dejstvo. Ovaj lek je bio ispitivan za moguću primenu na ljudima, mada nije odobren zbog nuspojava, kao što su depresija i anksioznost.[2][3]



Hemijska sinteza


Ekopipam se može sintetisati iz jednostavnog derivata tetralina:[4]



Ecopipam scheme.png


Reference




  1. ^ Chipkin RE, Iorio LC, Coffin VL, McQuade RD, Berger JG, Barnett A (1988). „Pharmacological profile of SCH39166: a dopamine D1 selective benzonaphthazepine with potential antipsychotic activity”. The Journal of Pharmacology and Experimental Therapeutics. 247 (3): 1093—102. PMID 2905002. 


  2. ^ Hou D, Schumacher D (2001). „The selection of a commercial route for the D1 antagonist Sch-39166”. Current Opinion in Drug Discovery & Development. 4 (6): 792—9. PMID 11899619. 


  3. ^ Astrup A, Greenway FL, Ling W, Pedicone L, Lachowicz J, Strader CD, Kwan R (2007). „Randomized controlled trials of the D1/D5 antagonist ecopipam for weight loss in obese subjects”. Obesity (Silver Spring, Md.). 15 (7): 1717—31. PMID 17636090. doi:10.1038/oby.2007.205. 


  4. ^ Hou, D; Schumacher, D (2001). „The selection of a commercial route for the D1 antagonist Sch-39166.”. Current opinion in drug discovery & development. 4 (6): 792—9. PMID 11899619. 



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Преузето из „https://sr.wikipedia.org/w/index.php?title=Ekopipam&oldid=12335591”










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