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Amoksapin Садржај Farmakologija Reference Vidi još Spoljašnje veze Мени за навигацијуMonografijaa68220214028-44-5WHO2170201DB005432085R63VQ857OTD00228CHEBI:2675CHEMBL11136764165„Pharmacological profile of antidepressants and related compounds at human monoamine transporters”953782110.1016/S0014-2999(97)01393-9„Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2c receptor”887602310.1007/BF02246453„Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT2B receptors”15721011082180010.1038/sj.bjp.07033411666997„Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors”7908055„Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro”6086881„Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist”1613569910.1124/jpet.105.0921551966571„Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist”1594703610.1124/jpet.105.087965уууууу

Инхибитори преузимања норепинефринаИнхибитори преузимања серотонинаПиперазиниЛечење биполарног поремећајаДибензоксазепиниХлороарени5-ХТ7 антагонисти


tetraciklični antidepresivdibenzoksazepinsketriciklični antidepresivLoksapinainhibitor preuzimanjaserotoninanorepinefrina5-HT2A5-HT2B5-HT2C5-HT35-HT65-HT7D2α1-adrenergičkiD3D4H1 receptorafinitetomantagonistinverzni agonistdopaminski transporter5-HT1A5-HT1BD1α2-adrenergičkiH4mAChGABAA receptorβ-adrenergičke receptorealosternabenzodiazepinska mestaMPSOPSImeprdsrdodbpasspecspvoprocN5A5B5C6A6B6DAzaperonBenperidolBromperidolDroperidolFluanizonHaloperidolLenperonMoperonPipamperonSpiperonTimiperonTrifluperidolKlopimozidFluspirilenPenfluridolPimozidAcepromazinAcetofenazinButaperazinKarfenazinHloracizinHlorproetazinHlorpromazinCijamemazinDiksirazinFluacizinFlufenazinLevomepromazin/MetotrimeprazinMezoridazinPerazinPericijazinPerfenazinPiperacetazinPipotiazinProhlorperazinPromazinPrometazinPropiomazinSulforidazinTietilperazinTiopropazatTioproperazinTioridazinTrifluoperazinTriflupromazinHlorprotiksenKlopentiksolFlupentiksolTiotiksenZuklopentiksolButaklamolFluotracenLoksapinTrimipraminCinuperonMelperonSetoperonIloperidonOkaperidonPaliperidonRisperidonLurasidonePerospironRevospironTiospironZiprasidonAmperozidAripiprazolBifeprunoksBrekspiprazolElopiprazolUmespironAmoksapinAsenapinKarpipraminKlocapraminKlorotepinKlotiapinKlozapinFluperlapinGevotrolinMetitepinMosapraminNDMCOlanzapinPihindonKvetijapinTenilapinZotepinWHO-EMPovučeniKlinička ispitivanjaFaza IIINije dospeo do faze IIIMPSOPSImeprdsrdodbpasspecspvoprocN5A5B5C6A6B6DAkrivastinAlinastinAstemizolAzelastinBamirastinBarmastinBepiastinBepotastinBilastinKabastinenKarebastinKetirizinKlemastinKlemizolKlobenztropinDorastinEbastinEmedastinEpinastinFlezelastinKetotifenLatrepirdinLevokabastinLinetastinLoratadinMapinastinMebhidrolinMizolastinMoksastinNoberastinOktastinOlopatadinPerastinPiklopastinRokastinRupatadinSetastinTalastinTemelastinTerfenadinZepastinDesloratadinFeksofenadinCetirizin‎‎LevocetirizinBelarizinEfletirizinElbanizinFlotrenizinMedrilaminNapaktadinPibaksizinTagorizinTrelnarizinTrenizinVapitadin










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Amoksapin




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Amoksapin (Amokisan, Asendin, Asendis, Defanil, Demoloks, Moksadil) je tetraciklični antidepresiv iz dibenzoksazepinske familije, mada se on često klasifikuje kao sekundarni aminski triciklični antidepresiv. On je N-demetilisani metabolit Loksapina.




Садржај





  • 1 Farmakologija


  • 2 Reference


  • 3 Vidi još


  • 4 Spoljašnje veze




Farmakologija


Amoksapin ispoljava mnoštvo farmakoloških efekata. On je umeren i jak inhibitor preuzimanja serotonina i norepinefrina, respektivno,[2] i vezuje se za 5-HT2A,[3]5-HT2B,[4]5-HT2C,[3]5-HT3,[5]5-HT6,[6]5-HT7,[6]D2,[7]α1-adrenergički,[7]D3[8], D4,[8] i H1 receptor[7] sa promenljivim ali značajnim afinitetom, na njijima deluje kao antagonist (ili inverzni agonist u zavisnosti od receptora) na svim aktivnim mestima. On ima slab i zanemarljiv afinitet za dopaminski transporter i 5-HT1A,[5]5-HT1B,[5]D1,[9]α2-adrenergički,[7]H4,[10]mACh,[7] i GABAA receptor,[9] i nema afiniteta za β-adrenergičke receptore ili za alosterna benzodiazepinska mesta na GABAA receptoru.[9]



Reference




  1. ↑ 1,01,1 Kinney JL, Evans RL (1982). „Evaluation of amoxapine”. Clinical Pharmacy. 1 (5): 417—24. PMID 6764165. 


  2. ^ Tatsumi M, Groshan K, Blakely RD, Richelson E (1997). „Pharmacological profile of antidepressants and related compounds at human monoamine transporters”. European Journal of Pharmacology. 340 (2–3): 249—58. PMID 9537821. doi:10.1016/S0014-2999(97)01393-9. 


  3. ↑ 3,03,1 Pälvimäki EP; Roth BL; Majasuo H; et al. (1996). „Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2c receptor”. Psychopharmacology. 126 (3): 234—40. PMID 8876023. doi:10.1007/BF02246453. CS1 одржавање: Експлицитна употреба et al. (веза)


  4. ^ Glusa E, Pertz HH (2000). „Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT2B receptors”. British Journal of Pharmacology. 130 (3): 692—8. PMC 1572101 Слободан приступ. PMID 10821800. doi:10.1038/sj.bjp.0703341. 


  5. ↑ 5,05,15,2 Gozlan H, Saddiki-Traki F, Merahi N, Laguzzi R, Hamon M (1991). „[Preclinical pharmacology of amoxapine and amitriptyline. Implications of serotoninergic and opiodergic systems in their central effect in rats]”. L'Encéphale (на језику: French). 17 Spec No 3: 415—22. PMID 1666997. CS1 одржавање: Непрепознат језик (веза)


  6. ↑ 6,06,1 Roth BL; Craigo SC; Choudhary MS; et al. (1994). „Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors”. The Journal of Pharmacology and Experimental Therapeutics. 268 (3): 1403—10. PMID 7908055. CS1 одржавање: Експлицитна употреба et al. (веза)


  7. ↑ 7,07,17,27,37,4 Richelson E, Nelson A (1984). „Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro”. The Journal of Pharmacology and Experimental Therapeutics. 230 (1): 94—102. PMID 6086881. 


  8. ↑ 8,08,1 Burstein ES; Ma J; Wong S; et al. (2005). „Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist”. The Journal of Pharmacology and Experimental Therapeutics. 315 (3): 1278—87. PMID 16135699. doi:10.1124/jpet.105.092155. CS1 одржавање: Експлицитна употреба et al. (веза)


  9. ↑ 9,09,19,2 Wei HB, Niu XY (1990). „[Comparison of the affinities of amoxapine and loxapine for various receptors in rat brain and the receptor down-regulation after chronic administration]”. Yao Xue Xue Bao = Acta Pharmaceutica Sinica (на језику: Chinese). 25 (12): 881—5. PMID 1966571. CS1 одржавање: Непрепознат језик (веза)


  10. ^ Lim HD, van Rijn RM, Ling P, Bakker RA, Thurmond RL, Leurs R (2005). „Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist”. The Journal of Pharmacology and Experimental Therapeutics. 314 (3): 1310—21. PMID 15947036. doi:10.1124/jpet.105.087965. 



Vidi još


  • Loksapin


Spoljašnje veze




Amoksapin
Amoxapine.svg

IUPAC ime
2-hloro-11-(piperazin-1-il)dibenzo[b,f][1,4]oksazepin
Klinički podaci
Prodajno imeAsendin
Drugs.comMonografija
MedlinePlusa682202
Kategorija trudnoće


  • US: C (Mogući rizik)

Način primeneOralnot
Pravni status
Pravni status


  • US: ℞-only


Farmakokinetički podaci
Bioraspoloživost?
Vezivanje proteina90%[1]
MetabolizamHepatički (citohrom P450)
Poluvreme eliminacije8-10 sata (30 sata za glavne metabolite)[1]
IzlučivanjeRenal

Identifikatori
CAS broj
14028-44-5 ДаY
ATC kod
N06AA17 (WHO)
PubChemCID 2170
IUPHAR/BPS201
DrugBank
DB00543 ДаY
ChemSpider
2085 ДаY
UNII
R63VQ857OT ДаY
KEGG
D00228 ДаY
ChEBI
CHEBI:2675 ДаY
ChEMBL
CHEMBL1113 ДаY
Hemijski podaci
Formula
C17H16ClN3O
Molarna masa313,781 g/mol











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Ethnic groups”„Jews, by country of origin and age”„Minority Communities in Israel: Background & Overview”„Israel”„Language in Israel”„Selected Data from the 2011 Social Survey on Mastery of the Hebrew Language and Usage of Languages”„Religions”„5 facts about Israeli Druze, a unique religious and ethnic group”„Israël”Israel Country Study Guide„Haredi city in Negev – blessing or curse?”„New town Harish harbors hopes of being more than another Pleasantville”„List of localities, in alphabetical order”„Muncitorii români, doriți în Israel”„Prietenia româno-israeliană la nevoie se cunoaște”„The Higher Education System in Israel”„Middle East”„Academic Ranking of World Universities 2016”„Israel”„Israel”„Jewish Nobel Prize Winners”„All Nobel Prizes in Literature”„All Nobel Peace Prizes”„All Prizes in Economic Sciences”„All Nobel Prizes in Chemistry”„List of Fields Medallists”„Sakharov Prize”„Țara care și-a sfidat "destinul" și se bate umăr la umăr cu Silicon Valley”„Apple's R&D center in Israel grew to about 800 employees”„Tim Cook: Apple's Herzliya R&D center second-largest in world”„Lecții de economie de la Israel”„Land use”Israel Investment and Business GuideA Country Study: IsraelCentral Bureau of StatisticsFlorin Diaconu, „Kadima: Flexibilitate și pragmatism, dar nici un compromis în chestiuni vitale", în Revista Institutului Diplomatic Român, anul I, numărul I, semestrul I, 2006, pp. 71-72Florin Diaconu, „Likud: Dreapta israeliană constant opusă retrocedării teritoriilor cureite prin luptă în 1967", în Revista Institutului Diplomatic Român, anul I, numărul I, semestrul I, 2006, pp. 73-74MassadaIsraelul a crescut in 50 de ani cât alte state intr-un mileniuIsrael Government PortalIsraelIsraelIsraelmmmmmXX451232cb118646298(data)4027808-634110000 0004 0372 0767n7900328503691455-bb46-37e3-91d2-cb064a35ffcc1003570400564274ge1294033523775214929302638955X146498911146498911

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Mentenanță CS1: Dată și anMentenanță CS1: Utilizare explicită a lui et al.IsraelȚări în Orientul MijlociuRepubliciSionismState membre ale Organizației Națiunilor Unite ebraicăarabărepublică parlamentarăOrientul MijlociuMării MediteraneLibanulSiriaIordaniaCisiordaniaEgiptFâșia GazaIerusalimTel AvivOrganizației Națiunilor Unite14 mai1948Mandatului britanic pentru PalestinaDavid Ben-GurionOrganizației SionisteAgenției Evreiești pentru PalestinaStatului IsraelONULiga ArabăpalestinieneRăzboiul arabo-israelian din 1948Conflict arabo-israelianTransiordaniaEgiptulRăzboiului de Șase ZileCisiordaniaPeninsula SinaiFâșia GazaÎnălțimile GolanBiroului Central de Statisticădruzicerchezisamariteniarmenidemocrație reprezentativăsistem parlamentarvot universalKnessetulgaze naturaleIndicelui Dezvoltării UmaneOCDEȚara I...
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Кастелфранко ди Сопра Становништво Референце Спољашње везе Мени за навигацију43°37′18″ СГШ; 11°33′32″ ИГД / 43.62156° СГШ; 11.55885° ИГД / 43.62156; 11.5588543°37′18″ СГШ; 11°33′32″ ИГД / 43.62156° СГШ; 11.55885° ИГД / 43.62156; 11.558853179688„The GeoNames geographical database”„Istituto Nazionale di Statistica”проширитиууWorldCat156923403n850174324558639-1cb14643287r(подаци)

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