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Benzatropin Садржај Medicinska upotreba Hemija Reference Spoljašnje veze Мени за навигацијуMonografija86-13-5WHO1201549DB00245167365411NHL2J4X8KCHEBI:3048CHEMBL1201203Goodman & Gilman's The Pharmacological Basis of Therapeutics10.1036/0071422803PDR: Physicians Desk Reference 2010 (Physicians' Desk Reference (Pdr))U.S. Patent 2.595.405ууу

Инхибитори преузимања допаминаАнтагонисти Х1 рецептораМускарински антагонистиТропаниЕтри


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Benzatropin




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Benzatropin (INN, benztropin) je antiholinergik koji je u prodaji pod imenom Kogentin. Koristi se za tretman Parkinsonove bolesti, parkinsonizma, i distonije.[1][2]




Садржај





  • 1 Medicinska upotreba


  • 2 Hemija


  • 3 Reference


  • 4 Spoljašnje veze




Medicinska upotreba


Benztropin je antiholinergički lek koji se koristi za redukovanje nuspojava antipsihotičkog tretmana, kao što je pseudoparkinsonizam i distonija.



Hemija


Benztropin, 3-(difenilmetoksi)tropan, se može sintetisati reakcijom tropina i difenildiazometana.[3]


Benztropine synthesis.png


Reference




  1. ^ Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803. 


  2. ^ Pdr Staff (2009). PDR: Physicians Desk Reference 2010 (Physicians' Desk Reference (Pdr)). Rozelle, N.S.W: Thomson Reuters. ISBN 1-56363-748-0. 


  3. ^ R.F. Phillips, N.J. Westfield, U.S. Patent 2.595.405 (1952).



Spoljašnje veze




Benztropin
Benzatropine.svg

IUPAC ime
(3-endo)-3-(difenilmetoksi)-8-metil-8-azabiciklo[3.2.1]oktan
Klinički podaci
Prodajno imeCogentin
Drugs.comMonografija
Kategorija trudnoće


  • US: C (Mogući rizik)

Način primeneOralno, IM, IV
Identifikatori
CAS broj
86-13-5 ДаY
ATC kod
N04AC01 (WHO)
PubChemCID 1201549
DrugBank
DB00245 НеН
ChemSpider
16736541 ДаY
UNII
1NHL2J4X8K ДаY
ChEBI
CHEBI:3048 ДаY
ChEMBL
CHEMBL1201203 ДаY
Hemijski podaci
Formula
C21H25NO
Molarna masa307,429 g/mol








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