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PF-219,061 Reference Vidi još Spoljašnje veze Мени за навигацију710654-74-3979447510.1016/j.bmcl.2007.10.05910.1016/j.ddstr.2006.10.006Van Der Graaf et al. SELECTIVE DOPAMINE D3 RECEPTOR AGONISTS FOR THE TREATMENT OF SEXUAL DYSFUNCTION. WIPO Patent WO/2003/051370, granted to Pfizerу

Допамински агонистиЛекови за женску сексуалну дисфункцијуМорфолиниФеноли


agonistdopaminskogD3receptoraPfizerimpotencije










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PF-219,061




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PF-219,061
PF-219,061 Structural Formulae.png

IUPAC ime
(R)-3-(4-propilmorfolin-2-il)fenol
Klinički podaci
Način primeneNazalno
Identifikatori
CAS broj
710654-74-3 ДаY
ATC kodnone
PubChemCID 9794475
Hemijski podaci
Formula
C13H19NO2
Molarna masa221,295 g/mol



PF-219,061 je potentan i visoko selektivan agonist dopaminskog D3 receptora.[1][2] Ovaj materijal razvija kompanija Pfizer kao potencijalni lek za tretiranje impotencije žena.[3][4]



Reference




  1. ^ Blagg J, Allerton CM, Batchelor DV, Baxter AD, Burring DJ, Carr CL, Cook AS, Nichols CL, Phipps J, Sanderson VG, Verrier H, Wong S. Design and synthesis of a functionally selective D3 agonist and its in vivo delivery via the intranasal route. Bioorganic and Medicinal Chemistry Letters. 2007 Dec 15;17(24):6691-6. doi:10.1016/j.bmcl.2007.10.059 PMID 17976986


  2. ^ Brioni JD, Moreland RB. Dopamine D4 receptors and the regulation of penile erection. Drug Discovery Today: Therapeutic Strategies. 2006;3(4):599-604. doi:10.1016/j.ddstr.2006.10.006


  3. ^ Van Der Graaf et al. SELECTIVE DOPAMINE D3 RECEPTOR AGONISTS FOR THE TREATMENT OF SEXUAL DYSFUNCTION. WIPO Patent WO/2003/051370, granted to Pfizer[мртва веза].


  4. ^ Attkins NJ, Heatherington AC, Phipps J, Verrier H, Huyghe I. Predictability of intranasal pharmacokinetics in man using pre-clinical pharmacokinetic data with a dopamine 3 receptor agonist, PF-219061. Xenobiotica. 2009 Jul;39(7):523-33. PMID 19480558



Vidi još


  • ABT-670

  • ABT-724

  • Kabergolin

  • Bremelanotid

  • Flibanserin

  • Intrinsa

  • Melanotan II

  • OSU-6162

  • Pramipeksol

  • Tibolon

  • UK-414,495


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